Vitamin A, Retinoic Acid / Diff Cancer Research Results

VitA,RetA, Vitamin A, Retinoic Acid: Click to Expand ⟱
Features:
Retinoic acid is a naturally occurring derivative of vitamin A (retinol).

Retinoic acid is produced in the body from dietary vitamin A. Vitamin A can be ingested in two primary forms:
• Preformed vitamin A (retinol and its esters) found in animal products like liver, dairy, and fish.
• Provitamin A carotenoids (such as beta-carotene) found in colorful fruits and vegetables. Once ingested, these compounds are converted into retinol, which can then be oxidized to retinal and further oxidized to retinoic acid.

All-trans retinoic acid (ATRA) is a key component in the treatment of acute promyelocytic leukemia (APL). In APL, ATRA induces the differentiation of malignant promyelocytes into mature granulocytes, leading to clinical remission.

-Retinoic acid can have antioxidant properties
-High levels of retinoic acid have been associated with increased ROS production and oxidative stress
-The potential prooxidant action may contribute to its anti-cancer effects by inducing oxidative damage in cancer cells, thereby enhancing apoptosis.
Diff, differentiation: Click to Expand ⟱
Source:
Type:
Differentiation refers to the process by which cells become specialized in structure and function.
-In healthy tissues, cells undergo differentiation to become specialized types (e.g., muscle cells, neurons, blood cells) that perform specific functions. This process is tightly regulated by genetic and epigenetic factors.
-In some cases, cells can lose their specialized characteristics, a process known as dedifferentiation. This is often seen in cancer, where tumor cells revert to a more primitive, less differentiated state.
Scientific Papers found: Click to Expand⟱
7011- Fuc,  ATO,  VitA,RetA,    Fucoidan enhances the therapeutic potential of arsenic trioxide and all-trans retinoic acid in acute promyelocytic leukemia, in vitro and in vivo
- NA, APL, APL NB4 - vitro+vivo, NA, NA
TumCCA↑, DNAdam↑, TumCP↓, Apoptosis↑, Diff↑, CD11b↑, eff↑, Dose↝,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Diff↑, 1,  

Migration(tgid=13) ⓘ

CD11b↑, 1,   TumCP↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,   eff↑, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Diff, differentiation
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:290  Target#:1235  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

Home Page