Terminalia bellirica / Akt Cancer Research Results

TBE, Terminalia bellirica: Click to Expand ⟱
Features:

Terminalia bellirica: The fruit extract contains multiple active constituents, including gallic acid, ellagic acid, corilagin, ethyl gallate, galloyl glucose, chebulagic acid and arjunolic acid.

Evidence level Primarily in vitro and animal evidence; limited human clinical evidence
Main research areas Inflammation, oxidative stress, metabolic effects, hepatoprotection and cancer
Primary preparation Fruit extract
Key constituents Gallic acid, ellagic acid, corilagin, chebulagic acid, ethyl gallate and related hydrolysable tannins


Akt, PKB-Protein kinase B: Click to Expand ⟱
Source: HalifaxProj(inhibit)
Type:
Akt1 is involved in cellular survival pathways, by inhibiting apoptotic processes; Akt2 is an important signaling molecule in the insulin signaling pathway. It is required to induce glucose transport.

Inhibitors:
-Curcumin: downregulate AKT phosphorylation and signaling.
-Resveratrol
-Quercetin: inhibit the PI3K/AKT pathway.
-Epigallocatechin Gallate (EGCG)
-Luteolin and Apigenin: inhibit AKT phosphorylation


Scientific Papers found: Click to Expand⟱
7036- TBE,  GA,    Terminalia bellirica (Gaertn.) Roxb. Extract and Gallic Acid Attenuate LPS-Induced Inflammation and Oxidative Stress via MAPK/NF-κB and Akt/AMPK/Nrf2 Pathways
- in-vitro, Nor, THP1 - in-vitro, Nor, RAW264.7
*ROS↓, *MAPK↓, *NF-kB↓, *TAC↑, *NRF2↑, *Akt↑, *AMPK↑, *Inflam↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

NRF2↑, 1,   ROS↓, 1,   TAC↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↑, 1,   MAPK↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,   NF-kB↓, 1,  
Total Targets: 8

Scientific Paper Hit Count for: Akt, PKB-Protein kinase B
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:427  Target#:4  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

Home Page