Rhein / Casp Cancer Research Results

Rhe, Rhein: Click to Expand ⟱
Features:

Rhein (4,5-dihydroxyanthraquinone-2-carboxylic acid) is a naturally occurring anthraquinone found particularly in rhubarb (Rheum palmatum, Rheum officinale and related species), as well as Polygonum multiflorum, Cassia species and Aloe. Rhein has demonstrated anti-inflammatory, antioxidant, antifibrotic, metabolic, neuroprotective and anticancer activities in preclinical studies. In cancer models, rhein can suppress proliferation, migration and invasion and promote cell-cycle arrest and apoptosis through mechanisms involving PI3K/AKT, MAPK, NF-κB, p53, mitochondrial apoptosis, oxidative-stress signalling and other pathways. Alzheimer-related experimental studies also suggest neuroprotective and anti-neuroinflammatory activity, including modulation of microglial metabolism and inflammatory signalling. Rhein should be maintained as a separate product from emodin, aloe-emodin, chrysophanol, physcion and whole rhubarb extracts because it is a chemically distinct anthraquinone with its own pharmacological and toxicological profile. Current therapeutic evidence remains predominantly preclinical, and potential hepatic and renal toxicity as well as poor water solubility and bioavailability should be considered when interpreting experimental findings.



Casp, caspase: Click to Expand ⟱
Source:
Type:
The caspase family of proteases are essential to initiate and execute apoptotic cell death. Targeting caspase pathways by gene therapy or endogenous inhibitors represents a promising therapeutic strategy for cancer.
Caspases are divided into two groups: the initiator caspases (caspase-2, -8, -9 and -10), which are the first to be activated in response to a signal, and the executioner caspases (caspase-3, -6, and -7) that carry out the demolition phase of apoptosis.
Caspases are a cysteine protease that speed up a chemical reaction via pointing their target substrates following an aspartic acid residue.1 They are grouped into apoptotic (caspase-2, 3, 6, 7, 8, 9 and 10) and inflammatory (caspase-1, 4, 5, 11 and 12) mediated caspases.
Scientific Papers found: Click to Expand⟱
7149- Rhe,    Inhibition of PI3K/AKT signaling via ROS regulation is involved in Rhein-induced apoptosis and enhancement of oxaliplatin sensitivity in pancreatic cancer cells
- in-vitro, PC, NA
TumCCA↑, Casp↑, mt-Apoptosis↑, PI3K↓, Akt↓, ChemoSen↑, ROS↑, eff↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   mt-Apoptosis↑, 1,   Casp↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

PI3K↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,   eff↓, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Casp, caspase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:432  Target#:443  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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