Ginkgolic acids / PTPN6 Cancer Research Results

GAs, Ginkgolic acids: Click to Expand ⟱
Features:

Ginkgolic acids (GAs) are a group of naturally occurring 2-hydroxy-6-alkylsalicylic acids found in Ginkgo biloba leaves, seeds and especially the seed coat. Major congeners include ginkgolic acid C13:0, C15:1 and C17:1. Ginkgolic acids have demonstrated antimicrobial, antiviral, autophagy-modulating and anticancer activities in preclinical studies. In cancer models, GAs can suppress proliferation, migration and invasion and promote apoptosis through mechanisms including inhibition of SUMOylation, STAT3 signalling, Hsp90 activity and other oncogenic pathways. Individual congeners can differ substantially in potency and biological activity, so specific forms such as C15:1 or C17:1 should be recorded separately when identified. Ginkgolic acids are kept separate from standardized Ginkgo biloba extracts because they are considered potentially toxic constituents and are deliberately reduced to very low concentrations in purified medicinal ginkgo preparations. Current anticancer evidence is predominantly preclinical.



PTPN6, SHP1/Protein Tyrosine Phosphatase, Non-Receptor Type 6: Click to Expand ⟱
Source:
Type:
Also known as SHP-1 (Src Homology 2 Domain-Containing Phosphatase 1)
SHP-1 (Src homology 2 domain-containing phosphatase-1) is a protein tyrosine phosphatase that plays a crucial role in regulating various cellular processes, including cell signaling, proliferation, and survival. Its expression has been implicated in the development and progression of various types of cancer.
Low SHP-1 expression is associated with poor prognosis, increased tumor size, and lymph node metastasis.
Scientific Papers found: Click to Expand⟱
1187- GAs,    Ginkgolic Acid C 17:1, Derived from Ginkgo biloba Leaves, Suppresses Constitutive and Inducible STAT3 Activation through Induction of PTEN and SHP-1 Tyrosine Phosphatase
- in-vitro, Melanoma, U251 - in-vitro, Melanoma, MM.1S
STAT3↓, PTEN↑, Apoptosis↑, PTPN6↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

PTEN↑, 1,   PTPN6↑, 1,   STAT3↓, 1,  
Total Targets: 4

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: PTPN6, SHP1/Protein Tyrosine Phosphatase, Non-Receptor Type 6
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:436  Target#:923  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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