Polyphenols / BDNF Cancer Research Results

Poly, Polyphenols: Click to Expand ⟱

Features:

Polyphenols are a large and structurally diverse family of plant-derived phenolic compounds characterized by multiple phenolic hydroxyl groups and encompassing major subclasses including flavonoids, phenolic acids, stilbenes, lignans, and tannins. They occur widely in fruits, vegetables, herbs, tea, coffee, cocoa, and medicinal plant extracts. Polyphenols exhibit broad biological activity involving redox regulation, inflammatory signaling, kinase pathways, apoptosis, cell-cycle control, angiogenesis, metabolism, and epigenetic regulation. In cancer models, many polyphenols inhibit proliferation, promote apoptosis or senescence, suppress invasion and angiogenesis, and can alter sensitivity to chemotherapy or radiotherapy. Effects are highly compound-, dose-, and context-dependent; antioxidant activity in normal tissues may coexist with pro-oxidant ROS induction in cancer cells. Oral bioavailability is frequently limited by poor absorption and extensive intestinal, hepatic, and microbial metabolism, making high-concentration in-vitro findings difficult to extrapolate directly to human systemic exposure.

Polyphenols — broad umbrella class of plant-derived phenolic compounds.

Flavonoids
- Flavones
  - Apigenin
  - Luteolin
- Flavonols
  - Quercetin
  - Kaempferol
  - Fisetin
- Flavan-3-ols
  - Catechin
  - Epicatechin
  - EGCG
- Flavanones
  - Hesperetin
  - Naringenin
- Isoflavones
  - Genistein
  - Daidzein
  - Formononetin
- Anthocyanins
  - Cyanidin
  - Delphinidin
  - Pelargonidin
- Chalcones
  - Isoliquiritigenin
  - Licochalcone A
  - Xanthohumol
  - Isobavachalcone
Phenolic acids
- Hydroxybenzoic acids
  - Gallic acid
  - Protocatechuic acid
  - Ellagic acid
- Hydroxycinnamic acids
  - Caffeic acid
  - Ferulic acid
  - p-Coumaric acid
  - Chlorogenic acid
  - Cynarin
Stilbenes
- Resveratrol
- Pterostilbene
Lignans
- Secoisolariciresinol
- Matairesinol
- Enterolactone
- Enterodiol
Tannins
- Hydrolyzable tannins
  - Gallotannins
  - Ellagitannins
- Condensed tannins
  - Proanthocyanidins

BDNF, brain-derived neurotrophic factor: Click to Expand ⟱

Source:

Type:

Brain-Derived Neurotrophic Factor (BDNF) is a key neurotrophin (a type of growth factor) involved in brain health, and its role in Alzheimer’s Disease (AD) has been extensively studied.
-AD patients often have lower BDNF levels in key brain regions, such as the hippocampus and cortex.
-This reduction correlates with cognitive decline and brain atrophy.
-BDNF normally protects neurons from Aβ toxicity
-Exercise and cognitive training have been shown to boost BDNF levels and may slow cognitive decline.
- natural compounds (like curcumin or flavonoids) may also upregulate BDNF.

Scientific Papers found: Click to Expand⟱

7517-

Poly,

Modulation of neurotrophic signaling pathways by polyphenols

Review,

Nor,

*NRF2↑, *HO-1↑, *NGF↑, *BDNF↑, *neuroP↑, p‑CREB↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Core Metabolism/Glycolysis(tgid=4) ⓘ

p‑CREB↑, 1,
Total Targets: 1

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

HO-1↑, 1, NRF2↑, 1,

Synaptic & Neurotransmission(tgid=18) ⓘ

BDNF↑, 1, NGF↑, 1,

Functional Outcomes(tgid=23) ⓘ

neuroP↑, 1,
Total Targets: 5

Scientific Paper Hit Count for: BDNF, brain-derived neurotrophic factor

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:450  Target#:1356  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid