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| Polyphenols are a large and structurally diverse family of plant-derived phenolic compounds characterized by multiple phenolic hydroxyl groups and encompassing major subclasses including flavonoids, phenolic acids, stilbenes, lignans, and tannins. They occur widely in fruits, vegetables, herbs, tea, coffee, cocoa, and medicinal plant extracts. Polyphenols exhibit broad biological activity involving redox regulation, inflammatory signaling, kinase pathways, apoptosis, cell-cycle control, angiogenesis, metabolism, and epigenetic regulation. In cancer models, many polyphenols inhibit proliferation, promote apoptosis or senescence, suppress invasion and angiogenesis, and can alter sensitivity to chemotherapy or radiotherapy. Effects are highly compound-, dose-, and context-dependent; antioxidant activity in normal tissues may coexist with pro-oxidant ROS induction in cancer cells. Oral bioavailability is frequently limited by poor absorption and extensive intestinal, hepatic, and microbial metabolism, making high-concentration in-vitro findings difficult to extrapolate directly to human systemic exposure. Polyphenols — broad umbrella class of plant-derived phenolic compounds.
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| Caspase-9 is the apoptotic initiator protease of the intrinsic or mitochondrial apoptotic pathway, which is activated at multi-protein activation platforms. Caspases are divided into two groups: the initiator caspases (caspase-2, -8, -9 and -10), which are the first to be activated in response to a signal, and the executioner caspases (caspase-3, -6, and -7) that carry out the demolition phase of apoptosis. Caspase-9: Role: Initiator caspase in the intrinsic apoptotic pathway. Cancers: Frequently studied in leukemia and solid tumors. Prognosis: Reduced expression is often linked to chemoresistance and poor prognosis. |
| 7413- | CS, | Poly, | Anticancer effects induced by artichoke extract in oral squamous carcinoma cell lines |
| - | in-vitro, | SCC, | SCC25 |
| 7416- | CS, | Poly, | Phenolic-Rich Extracts from Artichoke By-Products Promote Apoptosis in Human Colorectal Cancer Cell Lines |
| - | in-vitro, | Colon, | Caco-2 | - | in-vitro, | Colon, | HT29 |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:450 Target#:45 State#:% Dir#:2
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