diet FMD Fasting Mimicking Diet / IGFBP3 Cancer Research Results

dietFMD, diet FMD Fasting Mimicking Diet: Click to Expand ⟱

Features:

5-day diet to mimic fasting without fasting.
FMDs are caloric-restricted plant–based diets containing low proteins, low sugar and high fats which represent a more feasible and safer option to water-only fasting.

Fasting modality                         Approx CRIS
--------------------------------------   ----------
Time-restricted eating (12–16 h)          –3 to –4
Early time-restricted eating (eTRE)        –4
Intermittent fasting (24 h 1–2x/week)     –4
Periodic fasting / FMD                    –4 to –5*
Calorie restriction (chronic)             –3 (risk tradeoffs)

Compare STF(short term Fasting) to FMD
IGF-1 / insulin suppression (core driver)
| Aspect            | STF                 | FMD      |
| ----------------- | ------------------- | -------- |
| Depth             | **Very deep**       | Moderate |
| Speed             | **Rapid (24–48 h)** | Gradual  |
| Tumor stress      | **High**            | Medium   |
| Normal protection | High                | High     |

Fasting-Mimicking Diet (FMD; ~5-day low-protein, low-calorie cycle) Cancer vs Normal Cell Effects

Rank	Pathway / Axis	Cancer Cells	Normal Cells	Label	Primary Interpretation	Notes
1	Insulin / IGF-1 signaling	↓ IGF-1 signaling (chronic stress)	↓ IGF-1 with regenerative priming	Driver	Sustained growth factor suppression	Repeated IGF-1 lowering impairs tumor growth programs
2	AMPK → mTOR nutrient sensing	↓ mTOR; ↑ AMPK (growth inhibition)	↓ mTOR; ↑ AMPK (maintenance mode)	Driver	Prolonged anabolic suppression	More sustained but less acute than STF
3	Autophagy / mitophagy	↑ autophagy → loss of tumor robustness	↑ autophagy → rejuvenation	Driver	Cellular renewal vs destabilization	Repeated cycles promote organelle quality control
4	Mitochondrial metabolism	↓ metabolic resilience	↑ mitochondrial fitness	Secondary	Energy efficiency divergence	Normal cells adapt better across cycles
5	Inflammatory signaling (NF-κB / cytokines)	↓ pro-tumor inflammation	↓ systemic inflammation	Secondary	Anti-inflammatory milieu	Inflammation reduction contributes to chemopreventive effects
6	Reactive oxygen species (ROS)	↑ ROS (secondary, context-dependent)	↓ ROS	Secondary	Metabolism-linked redox shift	ROS effects are indirect and less pronounced than STF
7	NRF2 antioxidant response	↔ modest activation	↑ NRF2 (protective)	Adaptive	Stress adaptation	NRF2 supports normal-cell recovery between cycles
8	Cell cycle / regeneration	↓ proliferation	↑ regeneration post-cycle	Phenotypic	Degrowth vs regeneration	FMD uniquely promotes regeneration upon refeeding

IGFBP3, Insulin-Like Growth Factor Binding Protein-3: Click to Expand ⟱

Source:

Type:

One of the six members of the IGFBP family, is a key protein in the IGF pathway. IGFBP-3 is the most abundant in the blood circulation. Prostate specific antigen (PSA), which is frequently used as a clinical tumor marker for prostate cancer, cleaves IGFBP-3.

Tumor Types:
IGFBP-3 expression can vary significantly across different cancer types. It is often downregulated in several malignancies, including breast cancer, prostate cancer, colorectal cancer, and lung cancer.
In some cases, low levels of IGFBP-3 are associated with tumor progression and poor clinical outcomes.

Tumor Suppressor Functions:
IGFBP-3 is often considered a tumor suppressor due to its ability to inhibit the actions of IGF-1 and IGF-2, which promote cell proliferation and survival. By binding to IGFs, IGFBP-3 can prevent their interaction with IGF receptors, thereby inhibiting their mitogenic effects.

High levels of IGFBP-3 are generally associated with a favorable prognosis in several cancers. For example, elevated IGFBP-3 levels in breast cancer and prostate cancer have been linked to better survival outcomes.
Conversely, low levels of IGFBP-3 are often associated with aggressive tumor behavior and poorer prognosis.

Scientific Papers found: Click to Expand⟱

1842-

dietFMD,

Safety and Feasibility of Fasting-Mimicking Diet and Effects on Nutritional Status and Circulating Metabolic and Inflammatory Factors in Cancer Patients Undergoing Active Treatment

Trial,

Var,

Strength∅, Weight∅, IGF-1↓, IGFBP3↑, IGFBP1↑, eff↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Proliferation, Differentiation & Cell State ⓘ

IGF-1↓, 1, IGFBP1↑, 1, IGFBP3↑, 1,

Drug Metabolism & Resistance ⓘ

eff↑, 1,

Functional Outcomes ⓘ

Strength∅, 1, Weight∅, 1,
Total Targets: 6

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: IGFBP3, Insulin-Like Growth Factor Binding Protein-3

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells