GSK‐3β Cancer Research Results

GSK‐3β, Glycogen synthase kinase (GSK)3β: Click to Expand ⟱
Source:
Type:
GSK3β is a crucial member of the Wnt/β-catenin-, hedgehog (Hh)-, notch- and c-myc-mediated major pro-oncogenic pathways, while also being a negative regulator of epithelial–mesenchymal transition (EMT). Accumulating evidence defines GSK3β as a potential therapeutic target in cancer, thus encouraging the development of GSK3β inhibitors for cancer treatment.
Glycogen synthase kinase 3 beta (GSK-3β) is a serine/threonine kinase that plays a crucial role in various cellular processes, including cell proliferation, differentiation, and apoptosis. Its expression and activity have been implicated in several types of cancer, often with varying prognostic implications.

In many cancers, decreased GSK-3β activity is associated with poor prognosis, while in others, increased activity may correlate with aggressive disease.


Scientific Papers found: Click to Expand⟱
4305- Ba,    Study on the Molecular Mechanism of Baicalin Phosphorylation of Tau Protein Content in a Cell Model of Intervention Cognitive Impairment
- in-vitro, NA, SH-SY5Y
*cognitive↑, *p‑Akt↑, *p‑GSK‐3β↑, *p‑tau↓, *neuroP↑, *NF-kB↓, *AMPK↑, *NRF2↑,
5886- CAR,    Inhibition of TRPM7 with carvacrol suppresses glioblastoma functions in vivo
- in-vivo, GBM, U87MG - in-vivo, GBM, U251
TRPM7↓, TumVol↓, p‑Akt↓, p‑GSK‐3β↑, Dose↝,
3888- Cin,    Cinnamon, a promising prospect towards Alzheimer's disease
- NA, AD, NA
*tau↓, *Aβ↓, *neuroP↑, *ROS↓, *Inflam↓, *cardioP↑, *antiOx↑, *cognitive↑, *BBB↑, *p‑GSK‐3β↑, *AChE↓,
1860- dietFMD,  Chemo,    Fasting-mimicking diet blocks triple-negative breast cancer and cancer stem cell escape
- in-vitro, BC, SUM159 - in-vitro, BC, 4T1
PI3K↑, Akt↑, mTOR↑, CDK4↑, CDK6↑, hyperG↓, TumCG↓, TumVol↓, Casp3↑, BG↓, eff↑, eff∅, PKA↓, KLF5↓, p‑GSK‐3β↑, Nanog↓, OCT4↓, KLF2↓, eff↑, ROS↑, BIM↑, ASK1↑, PI3K↑, Akt↑, mTOR↑, CDK1↓, CDK4↑, CDK6↑, eff↑,
7765- ISL,    Isoliquiritigenin as a modulator of the Nrf2 signaling pathway: potential therapeutic implications
- Review, Var, NA
*antiOx↑, *AntiCan↑, *AntiTum↑, *AntiDiabetic↑, *cardioP↑, *RenoP↑, *NRF2↑, *NQO1↝, *HO-1↑, *SOD↑, *toxicity↓, *BioAv↓, *Half-Life↓, *BBB↑, *neuroP↑, *Stroke↓, *GSK‐3β↓, *p‑GSK‐3β↑, *hepatoP↑, *Inflam↓, *ROS↓, *MPO↓, *MDA↓,
7784- ISL,    Isoliquiritigenin attenuates lipopolysaccharide-induced cognitive impairment through antioxidant and anti-inflammatory activity
- in-vivo, AD, NA
*Learn↑, *PSD95↑, *BDNF↑, *SOD↑, *GPx↑, *Bcl-2↑, *SYP↑, *Bax:Bcl2↓, *TNF-α↓, *IL1β↓, *IL6↓, *MIP‑1α/CCL3↓, *p‑GSK‐3β↑, *NRF2↑, *HO-1↑, *NQO1↑, *cognitive↑, *Inflam↓,
7861- isoO,    Isoorientin Inhibits Inflammation in Macrophages and Endotoxemia Mice by Regulating Glycogen Synthase Kinase 3 β
- vitro+vivo, Nor, RAW264.7
*Inflam↓, *GSK‐3β↓, *TNF-α↓, *IL6↓, *IL1β↓, *p‑GSK‐3β↑, *eff↑, *COX2/PTGS2↓, *ERK↓, *NF-kB↓, *NRF2↑, *HO-1↑, *OCLN↑, *ZO-1↑, *BBB↝,
7876- isoO,    Isoorientin exerts a protective effect against 6-OHDA-induced neurotoxicity by activating the AMPK/AKT/Nrf2 signalling pathway
- in-vitro, Nor, NA
*neuroP↑, *ROS↓, *MMP↑, *GCLC↑, *GCLM↑, *HO-1↑, *NQO1↑, *Trx1↑, *NRF2↑, *Keap1↓, *p‑AMPK↑, *p‑ERK↑, *p‑GSK‐3β↑, *p‑JNK↑, *p‑PI3K↑, *p‑Akt↑, *AMPK↑, *Akt↑,
7870- isoO,    Anti-oxidative stress and cognitive improvement of a semi-synthetic isoorientin-based GSK-3β inhibitor in rat pheochromocytoma cell PC12 and scopolamine-induced AD model mice via AKT/GSK-3β/Nrf2 pathway
- vitro+vivo, AD, PC12
*GSK‐3β↓, *BAX↓, *Casp3↓, *cl‑Casp3↓, *Bcl-2↑, *MDA↓, *ROS↓, *SOD↑, *GPx↑, *p‑Akt↑, *p‑GSK‐3β↑, *NRF2↑, *p‑CREB↑, *BDNF⇅,
520- MF,    Exposure to a 50-Hz magnetic field induced mitochondrial permeability transition through the ROS/GSK-3β signaling pathway
- in-vitro, Nor, NA
*MPT↑, *Cyt‑c↑, *ROS↑, *p‑GSK‐3β↑, *eff↓, *MMP∅, *BAX↓, *Bcl-2∅,

Showing Research Papers: 1 to 10 of 10

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 10

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

hyperG↓, 1,   ROS↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

KLF5↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↑, 2,   p‑Akt↓, 1,   ASK1↑, 1,   BIM↑, 1,   Casp3↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK4↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑GSK‐3β↑, 2,   mTOR↑, 2,   Nanog↓, 1,   OCT4↓, 1,   PI3K↑, 2,   TRPM7↓, 1,   TumCG↓, 1,  

Migration(tgid=13) ⓘ

KLF2↓, 1,   PKA↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CDK6↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,   eff↑, 3,   eff∅, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BG↓, 1,  

Functional Outcomes(tgid=23) ⓘ

TumVol↓, 2,  
Total Targets: 25

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

Learn↑, 1,   Stroke↓, 1,   SYP↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   GCLC↑, 1,   GCLM↑, 1,   GPx↑, 2,   HO-1↑, 4,   Keap1↓, 1,   MDA↓, 2,   MPO↓, 1,   NQO1↑, 2,   NQO1↝, 1,   NRF2↑, 6,   ROS↓, 4,   ROS↑, 1,   SOD↑, 3,   Trx1↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↑, 1,   MMP∅, 1,   MPT↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 2,   p‑AMPK↑, 1,   p‑CREB↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↑, 1,   p‑Akt↑, 3,   BAX↓, 2,   Bax:Bcl2↓, 1,   Bcl-2↑, 2,   Bcl-2∅, 1,   Casp3↓, 1,   cl‑Casp3↓, 1,   Cyt‑c↑, 1,   p‑JNK↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↓, 1,   p‑ERK↑, 1,   GSK‐3β↓, 3,   p‑GSK‐3β↑, 8,   p‑PI3K↑, 1,  

Migration(tgid=13) ⓘ

ZO-1↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   BBB↝, 1,   OCLN↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   IL1β↓, 2,   IL6↓, 2,   Inflam↓, 4,   MIP‑1α/CCL3↓, 1,   NF-kB↓, 2,   TNF-α↓, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   BDNF↑, 1,   BDNF⇅, 1,   PSD95↑, 1,   tau↓, 1,   p‑tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   eff↓, 1,   eff↑, 1,   Half-Life↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   AntiDiabetic↑, 1,   AntiTum↑, 1,   cardioP↑, 2,   cognitive↑, 3,   hepatoP↑, 1,   neuroP↑, 4,   RenoP↑, 1,   toxicity↓, 1,  
Total Targets: 71

Scientific Paper Hit Count for: GSK‐3β, Glycogen synthase kinase (GSK)3β
3 isoorientin
2 Isoliquiritigenin
1 Baicalein
1 Carvacrol
1 Cinnamon
1 diet FMD Fasting Mimicking Diet
1 Chemotherapy
1 Magnetic Fields
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:385  State#:1  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

Home Page