Apoptosis Cancer Research Results

Apoptosis, Apoptosis: Click to Expand ⟱
Source:
Type: type of cell death
Situation in which a cell actively pursues a course toward death upon receiving certain stimuli.
Cancer is one of the scenarios where too little apoptosis occurs, resulting in malignant cells that will not die.
Scientific Papers found: Click to Expand⟱
4417- AgNPs,    Caffeine-boosted silver nanoparticles target breast cancer cells by triggering oxidative stress, inflammation, and apoptotic pathways
- in-vitro, BC, MDA-MB-231
ROS↑, MDA↑, COX2↑, IL1β↑, TNF-α↑, GSH↓, Cyt‑c↑, Casp3↑, BAX↑, Bcl-2↓, LDH↓, cycD1/CCND1↓, CDK2↓, TumCCA↑, mt-Apoptosis↑,
2734- BetA,    Betulinic Acid Modulates the Expression of HSPA and Activates Apoptosis in Two Cell Lines of Human Colorectal Cancer
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW480
tumCV↓, HSP70/HSPA5⇅, ROS↑, cl‑Casp3↑, mt-Apoptosis↑, Dose↝,
2733- BetA,    Betulinic Acid Inhibits Cell Proliferation in Human Oral Squamous Cell Carcinoma via Modulating ROS-Regulated p53 Signaling
- in-vitro, Oral, KB - in-vivo, NA, NA
TumCP↓, TumVol↓, mt-Apoptosis↑, Casp3↑, Casp9↑, BAX↑, Bcl-2↑, OCR↓, TumCCA↑, ROS↑, eff↓, P53↑, STAT3↓, cycD1/CCND1↑,
2735- BetA,    Betulinic acid as apoptosis activator: Molecular mechanisms, mathematical modeling and chemical modifications
- Review, Var, NA
mt-Apoptosis↑, Casp↑, p38↑, MAPK↓, JNK↓, VEGF↓, AIF↑, Cyt‑c↑, ROS↑, Ca+2↑, ATP↓, NF-kB↓, ATF3↓, TOP1↓, VEGF↓, survivin↓, Sp1/3/4↓, MMP↓, ChemoSen↑, selectivity↑, BioAv↓, BioAv↑, BioAv↑, BioAv↑, BioAv↑,
2753- BetA,    Betulinic acid induces apoptosis by regulating PI3K/Akt signaling and mitochondrial pathways in human cervical cancer cells
- in-vitro, Cerv, HeLa
PI3K↓, p‑Akt↓, ROS↑, TumCCA↑, p27↑, P21↑, mt-Apoptosis↑, BAD↑, Casp9↑, MMP↓, eff↓,
5658- BNL,    Natural borneol is a novel chemosensitizer that enhances temozolomide-induced anticancer efficiency against human glioma by triggering mitochondrial dysfunction and reactive oxide species-mediated oxidative damage
- vitro+vivo, GBM, U251
ChemoSen↑, mt-Apoptosis↑, Casp↑, DNAdam↑, ROS↑, angioG↓, BBB↑, EPR↑, TumVol↓, TumW↓, BioEnh↑,
5750- CA,    Exploration of the anticancer properties of Caffeic Acid in malignant mesothelioma cells
- in-vitro, MM, NA
eff↑, selectivity↑, Ki-67↓, PCNA↓, TumCP↓, p‑ERK↓, Akt↓, p27↑, P21↑, TumCCA↑, Bax:Bcl2↑, cl‑Casp3↑, mt-Apoptosis↑,
5897- CAR,    Carvacrol Selectively Induces Mitochondria-Related Apoptotic Signaling in Primary Breast Cancer-Associated Fibroblasts
- in-vitro, BC, NA
Bax:Bcl2↑, PPARα↓, NF-kB↓, SIRT1↑, SIRT3↑, MMP3↓, selectivity↑, Bcl-2↓, BAX↑, Casp3↑, Casp6↑, Casp9↑, mt-Apoptosis↑,

Showing Research Papers: 1 to 8 of 8

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 8

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ATF3↓, 1,   GSH↓, 1,   MDA↑, 1,   ROS↑, 6,   SIRT3↑, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   ATP↓, 1,   MMP↓, 2,   OCR↓, 1,  

Core Metabolism/Glycolysis ⓘ

LDH↓, 1,   PPARα↓, 1,   SIRT1↑, 1,  

Cell Death ⓘ

Akt↓, 1,   p‑Akt↓, 1,   mt-Apoptosis↑, 8,   BAD↑, 1,   BAX↑, 3,   Bax:Bcl2↑, 2,   Bcl-2↓, 2,   Bcl-2↑, 1,   Casp↑, 2,   Casp3↑, 3,   cl‑Casp3↑, 2,   Casp6↑, 1,   Casp9↑, 3,   Cyt‑c↑, 2,   JNK↓, 1,   MAPK↓, 1,   p27↑, 2,   p38↑, 1,   survivin↓, 1,  

Kinase & Signal Transduction ⓘ

Sp1/3/4↓, 1,  

Transcription & Epigenetics ⓘ

tumCV↓, 1,  

Protein Folding & ER Stress ⓘ

HSP70/HSPA5⇅, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   P53↑, 1,   PCNA↓, 1,  

Cell Cycle & Senescence ⓘ

CDK2↓, 1,   cycD1/CCND1↓, 1,   cycD1/CCND1↑, 1,   P21↑, 2,   TumCCA↑, 4,  

Proliferation, Differentiation & Cell State ⓘ

p‑ERK↓, 1,   PI3K↓, 1,   STAT3↓, 1,   TOP1↓, 1,  

Migration ⓘ

Ca+2↑, 1,   Ki-67↓, 1,   MMP3↓, 1,   TumCP↓, 2,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   EPR↑, 1,   VEGF↓, 2,  

Barriers & Transport ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↑, 1,   IL1β↑, 1,   NF-kB↓, 2,   TNF-α↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 4,   BioEnh↑, 1,   ChemoSen↑, 2,   Dose↝, 1,   eff↓, 2,   eff↑, 1,   selectivity↑, 3,  

Clinical Biomarkers ⓘ

Ki-67↓, 1,   LDH↓, 1,  

Functional Outcomes ⓘ

TumVol↓, 2,   TumW↓, 1,  
Total Targets: 70

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Apoptosis, Apoptosis
4 Betulinic acid
1 Silver-NanoParticles
1 borneol
1 Caffeic acid
1 Carvacrol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:14  State#:10  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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