ATF6 Cancer Research Results

ATF6, Activating Transcription Factor 6: Click to Expand ⟱
Source:
Type: protein
ATF6 (Activating Transcription Factor 6) is a protein that plays a crucial role in the unfolded protein response (UPR), a cellular stress response pathway that is activated in response to endoplasmic reticulum (ER) stress.
High ATF6 expression is associated with poor prognosis, including shorter overall survival and increased risk of recurrence.
Scientific Papers found: Click to Expand⟱
319- AgNPs,    Endoplasmic reticulum stress signaling is involved in silver nanoparticles-induced apoptosis
Apoptosis↑, Ca+2↑, ER Stress↑, PERK↑, IRE1↑, cl‑ATF6↑,
2288- AgNPs,    Silver Nanoparticle-Mediated Cellular Responses in Various Cell Lines: An in Vitro Model
- Review, Var, NA
*ROS↑, Akt↓, ERK↓, DNAdam↑, Ca+2↑, ROS↑, MMP↓, Cyt‑c↑, TumCCA↑, DNAdam↑, Apoptosis↑, P53↑, p‑ERK↑, ER Stress↑, cl‑ATF6↑, GRP78/BiP↑, CHOP↑, UPR↑,
2923- LT,    Luteolin induces apoptosis through endoplasmic reticulum stress and mitochondrial dysfunction in Neuro-2a mouse neuroblastoma cells
- in-vitro, NA, NA
Apoptosis↑, TumCD↑, Casp12↑, Casp9↑, Casp3↑, ER Stress↑, CHOP↑, GRP78/BiP↑, GRP94↑, cl‑ATF6↑, p‑eIF2α↑, MMP↓, JNK↓, p38↑, ERK↑, Cyt‑c↑,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 2,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↑, 3,   Casp12↑, 1,   Casp3↑, 1,   Casp9↑, 1,   Cyt‑c↑, 2,   JNK↓, 1,   p38↑, 1,   TumCD↑, 1,  

Protein Folding & ER Stress ⓘ

cl‑ATF6↑, 3,   CHOP↑, 2,   p‑eIF2α↑, 1,   ER Stress↑, 3,   GRP78/BiP↑, 2,   GRP94↑, 1,   IRE1↑, 1,   PERK↑, 1,   UPR↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 2,   P53↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↓, 1,   ERK↑, 1,   p‑ERK↑, 1,  

Migration ⓘ

Ca+2↑, 2,  
Total Targets: 27

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  
Total Targets: 1

Scientific Paper Hit Count for: ATF6, Activating Transcription Factor 6
2 Silver-NanoParticles
1 Luteolin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:861  State#:2  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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