IAP2/BIRC3 Cancer Research Results

IAP2/BIRC3, cIAP2, cellular Inhibitor of Apoptosis Protein 2: Click to Expand ⟱
Source:
Type:
IAP2 (cellular Inhibitor of Apoptosis Protein 2) is a member of the Inhibitor of Apoptosis (IAP) protein family.
• Like its family members, IAP2 functions to regulate cell survival primarily by inhibiting caspases and other components of the apoptotic machinery.
• IAP2 also influences signaling pathways, such as NF-κB, which affects inflammatory responses, cell proliferation, and survival.

• Overexpression or dysregulation of IAP2 has been observed in various malignancies.
– Elevated IAP2 levels can help tumor cells evade apoptosis, promoting tumor growth and survival.
– IAP2, similar to IAP1, may contribute to resistance against chemotherapies and targeted therapies by blocking cell death pathways.

BIRC3 - Baculoviral IAP Repeat Containing 3 / Cellular Inhibitor of Apoptosis Protein 2

Abbreviation: BIRC3, cIAP2

Type: Inhibitor of apoptosis protein / E3 ubiquitin ligase

Function: BIRC3/cIAP2 regulates apoptosis, inflammatory signaling, and cell survival through ubiquitination-dependent control of TNF receptor and NF-κB signaling pathways. It interacts with proteins including TRAF2 and RIPK1 and helps determine whether TNF-family signaling promotes survival, inflammation, or programmed cell death.

Cancer: ↕ Context-dependent. Increased BIRC3 can suppress apoptosis, activate NF-κB survival signaling, and promote resistance to chemotherapy and radiotherapy in several cancers. However, BIRC3 can also function as a tumor suppressor, particularly in some B-cell malignancies, where deletion or inactivating mutation is associated with increased NF-κB signaling, aggressive disease, and treatment resistance.
Scientific Papers found: Click to Expand⟱
2640- Api,    Apigenin: A Promising Molecule for Cancer Prevention
- Review, Var, NA
chemoPv↑, ITGB4↓, TumCI↓, TumMeta↓, Akt↓, ERK↓, p‑JNK↓, *Inflam↓, *PKCδ↓, *MAPK↓, EGFR↓, CK2↓, TumCCA↑, CDK1↓, P53↓, P21↑, Bax:Bcl2↑, Cyt‑c↑, APAF1↑, Casp↑, cl‑PARP↑, VEGF↓, Hif1a↓, IGF-1↓, IGFBP3↑, E-cadherin↑, β-catenin/ZEB1↓, HSPs↓, Telomerase↓, FASN↓, MMPs↓, HER2/EBBR2↓, CK2↓, eff↑, AntiAg↑, eff↑, FAK↓, ROS↑, Bcl-2↓, Cyt‑c↑, cl‑Casp3↑, cl‑Casp7↑, cl‑Casp8↑, cl‑Casp9↑, cl‑IAP2/BIRC3↑, AR↓, PSA↓, p‑pRB↓, p‑GSK‐3β↓, CDK4↓, ChemoSen↑, Ca+2↑, cal2↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

FASN↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   APAF1↑, 1,   Bax:Bcl2↑, 1,   Bcl-2↓, 1,   Casp↑, 1,   cl‑Casp3↑, 1,   cl‑Casp7↑, 1,   cl‑Casp8↑, 1,   cl‑Casp9↑, 1,   CK2↓, 2,   Cyt‑c↑, 2,   cl‑IAP2/BIRC3↑, 1,   p‑JNK↓, 1,   Telomerase↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

HER2/EBBR2↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

p‑pRB↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSPs↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↓, 1,   cl‑PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK4↓, 1,   P21↑, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↓, 1,   p‑GSK‐3β↓, 1,   IGF-1↓, 1,   IGFBP3↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   Ca+2↑, 1,   cal2↑, 1,   E-cadherin↑, 1,   FAK↓, 1,   ITGB4↓, 1,   MMPs↓, 1,   TumCI↓, 1,   TumMeta↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

EGFR↓, 1,   Hif1a↓, 1,   VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

PSA↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,   eff↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   EGFR↓, 1,   HER2/EBBR2↓, 1,   PSA↓, 1,  

Functional Outcomes(tgid=23) ⓘ

chemoPv↑, 1,  
Total Targets: 51

Pathway results for Effect on Normal Cells:


Cell Death(tgid=5) ⓘ

MAPK↓, 1,  

Migration(tgid=13) ⓘ

PKCδ↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,  
Total Targets: 3

Scientific Paper Hit Count for: IAP2/BIRC3, cIAP2, cellular Inhibitor of Apoptosis Protein 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:980  State#:2  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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