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| Tumor Microenvironment: Cancer cells often thrive in a more acidic environment compared to normal cells. This is partly due to the metabolic processes of cancer cells, which can produce lactic acid and other acidic byproducts. The acidic microenvironment can promote tumor growth and invasion. Many tumors exhibit an acidic microenvironment. This is largely due to the high rate of glycolysis (often referred to as the Warburg effect), even in the presence of oxygen, leading to lactate production. Acidification is thought to promote invasion, metastasis, and resistance to certain chemotherapies. The body maintains a relatively stable pH in the blood (around 7.4). However, the pH of tissues can vary, and tumors can exhibit a lower pH. -Normal tissues have a higher extracellular pH than intracellular pH, in cancer is exactly the opposite. (inversion of the pH gradient). Cancer cells often overexpress proton pumps (such as V-ATPase) and transporters that actively extrude protons (H⁺) to maintain an intracellular pH conducive to their growth. Inhibiting these pumps can lead to intracellular acidification and potentially induce apoptosis or render cancer cells more vulnerable to other treatments. Normal pH levels in the body: Nasal: ~6.3 pH Mouth/saliva: 6.2-7.6 pH Stomach: 1-3 pH Small Intestine: 5.9-6.8 pH Colon/Large Intestine: 6.8-7 pH |
| 5598- | NaHCO3, | Bicarbonate Increases Tumor pH and Inhibits Spontaneous Metastases |
| - | in-vivo, | BC, | MDA-MB-231 |
| 5620- | NaHCO3, | Tumor acidity: From hallmark of cancer to target of treatment |
| - | Review, | Var, | NA |
| 5616- | NaHCO3, | DCA, | Bicarbonate and dichloroacetate: Evaluating pH altering therapies in a mouse model for metastatic breast cancer |
| - | vitro+vivo, | BC, | MDA-MB-231 |
| 5614- | NaHCO3, | Targeting the Acidic Tumor Microenvironment: Unexpected Pro-Neoplastic Effects of Oral NaHCO3 Therapy in Murine Breast Tissue |
| - | in-vivo, | BC, | NA |
| 5612- | NaHCO3, | immuno, | Neutralization of tumor acidity improves anti-tumor responses to immunotherapies |
| - | vitro+vivo, | Var, | B16-F10 |
| 5599- | NaHCO3, | Acidity generated by the tumor microenvironment drives local invasion |
| - | in-vivo, | BC, | MDA-MB-231 | - | in-vitro, | CRC, | HCT116 |
| 5609- | NaHCO3, | Alkalization of cellular pH leads to cancer cell death by disrupting autophagy and mitochondrial function |
| - | in-vitro, | Var, | NA |
| 5608- | NaHCO3, | Sodium Bicarbonate Nanoparticles for Amplified Cancer Immunotherapy by Inducing Pyroptosis and Regulating Lactic Acid Metabolism |
| - | Study, | Var, | NA |
| 5607- | NaHCO3, | Does Baking Soda Function as a Magic Bullet for Patients With Cancer? A Mini Review |
| - | Review, | Var, | NA |
| 5603- | NaHCO3, | immuno, | Acidosis-mediated increase in IFN-γ-induced PD-L1 expression on cancer cells as an immune escape mechanism in solid tumors |
| - | in-vitro, | BC, | MCF-7 | - | in-vitro, | PC, | MIA PaCa-2 | - | in-vitro, | GBM, | U87MG |
| 5602- | NaHCO3, | immuno, | Immunotherapy Enhancement by Targeting Extracellular Tumor pH in Triple-Negative Breast Cancer Mouse Model |
| - | in-vivo, | BC, | 4T1 |
| 5601- | NaHCO3, | Tumor acidity, ion trapping and chemotherapeutics. II. pH-dependent partition coefficients predict importance of ion trapping on pharmacokinetics of weakly basic chemotherapeutic agents |
| - | vitro+vivo, | Var, | NA |
| 5600- | NaHCO3, | Acidosis and Cancer: from Mechanism to Neutralization |
| - | Review, | Var, | NA |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:250 State#:4 Dir#:2
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