Iron Cancer Research Results

Iron, Iron: Click to Expand ⟱
Source:
Type:
Iron is an essential nutrient that is crucial for various cellular processes, including DNA synthesis, cell proliferation, and oxygen transport.
Cancer cells often have increased iron requirements due to their rapid growth and proliferation. Some tumors can acquire iron through various mechanisms, including upregulating iron transport proteins. This can support their growth and survival.
Excess iron can lead to the production of reactive oxygen species (ROS) through Fenton reactions, which can cause oxidative damage to DNA, proteins, and lipids. This oxidative stress can contribute to cancer development and progression.
Scientific Papers found: Click to Expand⟱
1447- Bos,    Boswellia carterii n-hexane extract suppresses breast cancer growth via induction of ferroptosis by downregulated GPX4 and upregulated transferrin
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7 - in-vivo, BC, 4T1 - in-vitro, Nor, MCF10
tumCV↓, AntiCan↑, *toxicity↓, Ferroptosis↑, i-Iron↑, GPx4↓, ROS↑, lipid-P↑, Tf↑, TumCG↓,
6891- Fer,    Iron oxide nanoparticles inhibit tumor growth by ferroptosis in diffuse large B-cell lymphoma
- vitro+vivo, lymphoma, NA
TumCG↓, Ferroptosis↑, i-Iron↑, lipid-P↑, GPx4↓, ROS↑, Fenton↑, TfR1/CD71↝, FPN↝, LIP↑, TumCP↓, Apoptosis↑, TumCG↓,
6893- Fer,  VitC,    MRI Detection and Therapeutic Enhancement of Ferumoxytol Internalization in Glioblastoma Cells
- in-vitro, GBM, U87MG - in-vitro, GBM, U251 - in-vitro, GBM, U118MG
eff↑, i-Iron↑, AntiCan↑, ROS↓, H2O2↑,
7046- GA,    Gallic acid: A promising anti-non-small cell lung cancer compound targeting early growth response protein-1 for apoptosis and ferroptosis
- in-vitro, NSCLC, A549 - in-vitro, NSCLC, H1299
TumCP↓, TumCCA↑, TumCMig↓, TumCI↓, Apoptosis↑, Ferroptosis↑, THBS1↓, EGR1↓, TGF-β1↓, SMAD2↓, SMAD3↓, GPx4↓, ROS↑, i-MDA↑, i-Iron↑,
7242- Gink,  Cisplatin,    Ginkgetin reverses cisplatin resistance in cervical cancer by regulating the Nrf2/HO-1 signaling pathway to induce ferroptosis
- in-vitro, Cerv, HeLa
TumCP↓, NRF2↓, ROS↑, i-Iron↑, GSH↓, SOD↓, Catalase↓, lipid-P↑, ACSL4↑, NO↓, GPx4↓, Ferroptosis↑,
7803- IBC,    Isobavachalcone induces hepatotoxicity in zebrafish embryos and HepG2 cells via the System Xc--GSH-GPX4 signaling pathway in ferroptosis response
- in-vivo, Nor, NA - in-vitro, NA, HepG2
*hepatoP↓, *ALAT↑, *AST↑, *ROS↑, *MDA↑, *Catalase↓, *GSH↓, *GPx↓, *i-Iron↑,
7761- ISL,    Targeting digestive system cancers with isoliquiritigenin: a comprehensive review of antitumor mechanisms
- Review, Var, NA
Apoptosis↑, TumAuto↑, TumCCA↑, ROS↑, JNK↑, p38↑, STAT3↑, NF-kB↓, IκB↑, Bcl-2↓, BAX↑, cl‑Casp3↑, cl‑PARP↑, P21↑, p27/CDKN1B↑, CycB/CCNB1↑, CDK1↓, CDK2↓, GRP78/BiP↓, PI3K↓, Akt↓, mTOR↓, eff↑, GLUT4↓, lactateProd↓, OXPHOS↓, Glycolysis↓, BioAv↑, ENO1↓, ALDOA↓, LDHA↓, MCT4↓, RadioS↑, Ferroptosis↑, i-Iron↑, BioAv↑, Half-Life↓,
7777- ISL,    Isoliquiritigenin induces HMOX1 and GPX4-mediated ferroptosis in gallbladder cancer cells
- vitro+vivo, Gall, SGC996
TumCP↓, Ferroptosis↑, HO-1↑, GPx4↓, i-Iron↑, ROS↑, lipid-P↑, GSH/GSSG↓, TumCG↓, NRF2↑,
7871- isoO,  Cisplatin,    Isoorientin reverses lung cancer drug resistance by promoting ferroptosis via the SIRT6/Nrf2/GPX4 signaling pathway
- vitro+vivo, Lung, NA
ChemoSen↑, i-Iron↑, i-MDA↑, *i-ROS↑, GSH↓, Ferroptosis↑, NRF2↓, GPx4↓, SIRT6↓,
1483- SFN,    Targeting p62 by sulforaphane promotes autolysosomal degradation of SLC7A11, inducing ferroptosis for osteosarcoma treatment
- in-vitro, OS, 143B - in-vitro, Nor, HEK293 - in-vivo, OS, NA
AntiCan↑, *toxicity∅, Ferroptosis↑, ROS↑, lipid-P↑, GSH↓, p62↑, SLC12A5↓, eff↓, GPx4↓, i-Iron↑, eff↓, MDA↑, TumVol↓, TumW↓, Ki-67↓, LC3B↑, *Weight∅,

Showing Research Papers: 1 to 10 of 10

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 10

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

FPN↝, 1,   LIP↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↓, 1,   Fenton↑, 1,   Ferroptosis↑, 8,   GPx4↓, 7,   GSH↓, 3,   GSH/GSSG↓, 1,   H2O2↑, 1,   HO-1↑, 1,   i-Iron↑, 9,   lipid-P↑, 5,   MDA↑, 1,   i-MDA↑, 2,   NRF2↓, 2,   NRF2↑, 1,   OXPHOS↓, 1,   ROS↓, 1,   ROS↑, 7,   SOD↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Tf↑, 1,   TfR1/CD71↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACSL4↑, 1,   ALDOA↓, 1,   ENO1↓, 1,   Glycolysis↓, 1,   lactateProd↓, 1,   LDHA↓, 1,   MCT4↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Apoptosis↑, 3,   BAX↑, 1,   Bcl-2↓, 1,   cl‑Casp3↑, 1,   Ferroptosis↑, 8,   JNK↑, 1,   p27/CDKN1B↑, 1,   p38↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

GRP78/BiP↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3B↑, 1,   p62↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

cl‑PARP↑, 1,   SIRT6↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 1,   CycB/CCNB1↑, 1,   P21↑, 1,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

mTOR↓, 1,   PI3K↓, 1,   STAT3↑, 1,   TumCG↓, 4,  

Migration(tgid=13) ⓘ

Ki-67↓, 1,   SMAD2↓, 1,   SMAD3↓, 1,   TGF-β1↓, 1,   THBS1↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 4,  

Angiogenesis & Vasculature(tgid=14) ⓘ

EGR1↓, 1,   NO↓, 1,  

Barriers & Transport(tgid=15) ⓘ

GLUT4↓, 1,   SLC12A5↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IκB↑, 1,   NF-kB↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 2,   ChemoSen↑, 1,   eff↓, 2,   eff↑, 2,   Half-Life↓, 1,   RadioS↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

Ki-67↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 3,   TumVol↓, 1,   TumW↓, 1,  
Total Targets: 78

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↓, 1,   GPx↓, 1,   GSH↓, 1,   i-Iron↑, 1,   MDA↑, 1,   ROS↑, 1,   i-ROS↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↑, 1,   AST↑, 1,  

Functional Outcomes(tgid=23) ⓘ

hepatoP↓, 1,   toxicity↓, 1,   toxicity∅, 1,   Weight∅, 1,  
Total Targets: 14

Scientific Paper Hit Count for: Iron, Iron
2 ferumoxytol
2 Cisplatin
2 Isoliquiritigenin
1 Boswellia (frankincense)
1 Vitamin C (Ascorbic Acid)
1 Gallic acid
1 Ginkgetin
1 Isobavachalcone
1 isoorientin
1 Sulforaphane (mainly Broccoli)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:160  State#:8  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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