toxicity Cancer Research Results

toxicity, toxicity: Click to Expand ⟱
Source:
Type:
Toxicity
Scientific Papers found: Click to Expand⟱
5260- 3BP,    Systemic Delivery of Microencapsulated 3-Bromopyruvate for the Therapy of Pancreatic Cancer
- in-vivo, PC, NA
TumCG↓, toxicity↓, BioAv↝, GAPDH↓, toxicity↑, Dose↝, ATP↓, eff↑, TumCI↓, MMP9↓, toxicity↓,
5269- 3BP,    The anti-metabolite KAT/3BP has in vitro and in vivo anti-tumor activity in lymphoma models.
- in-vitro, HCC, NA
toxicity↑, eff↝, eff↑, Glycolysis↓, HK2↓, AIF↑, Apoptosis↑, NK cell↑, toxicity↑, toxicity↓, Dose↝, AntiTum↑,
5264- 3BP,    Candidate cancer drug suspected after death of three patients at an alternative medicine clinic
- Review, Var, NA
toxicity↑, Glycolysis↓, eff↑, OS↑, QoL↑, toxicity↝,
5302- 5-HTP,    Hippocampal ischaemia from accidental 5-Hydroxytryptophan (5-HTP) overdose case report
- Case Report, Nor, NA
*toxicity↑, *Dose↑,
5294- 5-HTP,    Eosinophilia-myalgia syndrome case-associated contaminants in commercially available 5-hydroxytryptophan
- in-vivo, Nor, NA
*toxicity↑,
4759- antiOx,  Chemo,    Potential Contributions of Antioxidants to Cancer Therapy: Immunomodulation and Radiosensitization
- Review, Var, NA
TumCD↑, TumCG↓, ROS⇅, eff↑, RadioS↑, TumCG↓, OS↑, toxicity∅, toxicity↑,
3382- ART/DHA,    Repurposing Artemisinin and its Derivatives as Anticancer Drugs: A Chance or Challenge?
- Review, Var, NA
AntiCan↑, toxicity↑, Ferroptosis↑, ROS↑, TumCCA↑, BioAv↝, eff↝, Half-Life↓, Ferritin↓, GPx4↓, NADPH↓, GSH↓, BAX↑, Cyt‑c↑, cl‑Casp3↑, VEGF↓, IL8↓, COX2↓, MMP9↓, E-cadherin↑, MMP2↓, NF-kB↓, p16↑, CDK4↓, cycD1/CCND1↓, p62↓, LC3II↑, EMT↓, CSCs↓, Wnt↓, β-catenin/ZEB1↓, uPA↓, TumAuto↑, angioG↓, ChemoSen↑,
5572- B-Gluc,    The Effects of Orally Administered Beta-Glucan on Innate Immune Responses in Humans, a Randomized Open-Label Intervention Pilot-Study
- Study, Nor, NA
Imm↑, *Dose↝, *BioAv↓, *toxicity↑,
932- BBR,    The short-term effects of berberine in the liver: Narrow margins between benefits and toxicity
- in-vivo, Nor, NA
*glucoNG↓, *Glycolysis↑, *NH3↑, *NADPH/NADP+↑, *ATP↓, *toxicity↑,
5948- Cela,    Recent Trends in anti-tumor mechanisms and molecular targets of celastrol
TumCP↓, TumCCA↑, Apoptosis↑, TumAuto↑, TumCI↓, TumMeta↓, Imm↝, angioG↓, Cyt‑c↑, ROS↑, BAX↑, Casp3↑, Casp9↑, cl‑PARP↑, PrxII↓, ER Stress↑, mtDam↑, CHOP↑, Inflam↓, NF-kB↓, CXCR4↓, MMP9↓, IL6↓, TNF-α↓, HSP90↓, neuroP↑, STAT3↓, Prx↓, HO-1↑, eff↑, eff↑, BioAv↑, toxicity↑, CardioT↑, hepatoP↓,
1442- Deg,    Deguelin, a novel anti-tumorigenic agent targeting apoptosis, cell cycle arrest and anti-angiogenesis for cancer chemoprevention
- Review, Var, NA
PI3K/Akt↓, IKKα↓, AMP↓, mTOR↓, survivin↓, NF-kB↓, Apoptosis↑, TumCCA↑, toxicity↓, HSP90↓, Casp↑, TumCG↓, p27↑, cycE/CCNE↓, angioG↓, Hif1a↓, VEGF↓, *toxicity↑,
4917- DSF,  Chemo,  Cu,    Effect of Disulfiram and Copper Plus Chemotherapy vs Chemotherapy Alone on Survival in Patients With Recurrent Glioblastoma
- Trial, GBM, NA
OS∅, toxicity↑,
1324- EMD,    Is Emodin with Anticancer Effects Completely Innocent? Two Sides of the Coin
- Review, Var, NA
*toxicity↑, *BioAv↓, Akt↓, ERK↓, ROS↑, MMP↓, Bcl-2↓, BAX↑, TumCCA↑,
2861- FIS,    The neuroprotective effects of fisetin, a natural flavonoid in neurodegenerative diseases: Focus on the role of oxidative stress
- Review, Nor, NA - Review, Stroke, NA - Review, Park, NA
*antiOx↑, *ROS↓, *neuroP↑, *NO↑, BioAv↝, *BBB↑, *toxicity↑, *eff↑, *GSH↑, *SOD↑, *Aβ↓, *12LOX↓, *COX2↓, *Catalase↑, *Inflam↓, *TNF-α↓, *IL6↑, *lipid-P↓, NF-kB↓, IL1β↓, NRF2↑, HO-1↑, GSTs↑, cognitive↑, *BDNF↑,
4016- FulvicA,    Shilajit: A Natural Phytocomplex with Potential Procognitive Activity
- Review, AD, NA
*tau↓, *AntiAge↑, *Strength↑, *Dose↝, *BioAv↑, *antiOx↑, *memory↑, *Inflam↓, *cognitive↑, *neuroP↑, *toxicity↝, *toxicity↑,
2079- HNK,    Honokiol Microemulsion Causes Stage-Dependent Toxicity Via Dual Roles in Oxidation-Reduction and Apoptosis through FoxO Signaling Pathway
- in-vitro, Nor, PC12
*toxicity↝, *ROS↓, *ROS↑, *Dose⇅, *BioAv↑, *BioAv↓, *ROS⇅, *SOD↓, *toxicity↑,
1534- LT,  Api,  EGCG,  RES,    Plant polyphenol induced cell death in human cancer cells involves mobilization of intracellular copper ions and reactive oxygen species generation: a mechanism for cancer chemopreventive action
- in-vitro, Nor, MCF10 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468 - in-vitro, PC, Bxpc-3
TumCP↓, Apoptosis↑, eff↓, *toxicity↑, Dose?, eff↓, eff↓,
1665- PBG,    Evidence on the Health Benefits of Supplemental Propolis
- Review, Nor, NA
*antiOx↑, *Inflam↓, *toxicity↑, *Dose?,
1941- PL,    Piperlongumine selectively kills cancer cells and increases cisplatin antitumor activity in head and neck cancer
- in-vitro, HNSCC, NA
selectivity↑, eff↑, ROS↑, toxicity↑, GSH↓, GSSG↑, *GSSG∅, cl‑PARP↑, PUMA↑, GSTP1/GSTπ↓, ChemoSen↑,
4486- Se,  Chit,    Selenium-Modified Chitosan Induces HepG2 Cell Apoptosis and Differential Protein Analysis
- in-vitro, Liver, HepG2
Apoptosis↑, TumCCA↑, MMP↓, Bcl-2↓, BAX↑, cl‑Casp9↑, cl‑Casp3↑, Risk↓, *BioAv↑, *toxicity↑, TumCG↓, AntiTum↑, ROS↑, Cyt‑c↑, Fas↑, FasL↑, FADD↑,
1706- SSE,    Selenium in Prostate Cancer: Prevention, Progression, and Treatment
- Review, Pca, NA
Risk∅, ChemoSen↑, Risk↓, toxicity↝, Risk↑, eff↑, *toxicity↑, RadioS↑, eff↓, eff↑, ChemoSen↑, ChemoSideEff↓,
5334- TFdiG,    Theaflavin inhibits the malignant phenotype of human anaplastic thyroid cancer 8305C cells by regulating lipid metabolism via PI3K/AKT signaling
- in-vitro, Thyroid, 8505C
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, Casp3↑, Casp8↑, Casp9↑, survivin↓, SREBP1↓, toxicity↑,
1888- VitB1/Thiamine,  DCA,    High Dose Vitamin B1 Reduces Proliferation in Cancer Cell Lines Analogous to Dichloroacetate
- in-vitro, PC, SK-N-BE - NA, PC, PANC1
p‑PDH↓, GlucoseCon↓, lactateProd↓, MMP↓, Casp3↑, eff↑, PDKs↓, selectivity↑, TumCG↓, Dose∅, MMP↓, ROS∅, toxicity↑, antiOx↑,
2283- VitK2,    Vitamin K Contribution to DNA Damage—Advantage or Disadvantage? A Human Health Response
- Review, Var, NA
*ER Stress↓, *toxicity↓, *toxicity↑, ROS↑, PI3K↑, Akt↑, Hif1a↑, GlucoseCon↑, lactateProd↑, ChemoSen↑, eff↑, eff↑,

Showing Research Papers: 1 to 24 of 24

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 24

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Ferroptosis↑, 1,   GPx4↓, 1,   GSH↓, 2,   GSSG↑, 1,   GSTP1/GSTπ↓, 1,   GSTs↑, 1,   HO-1↑, 2,   NRF2↑, 1,   Prx↓, 1,   PrxII↓, 1,   ROS↑, 6,   ROS⇅, 1,   ROS∅, 1,  

Metal & Cofactor Biology ⓘ

Ferritin↓, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   ATP↓, 1,   MMP↓, 4,   mtDam↑, 1,  

Core Metabolism/Glycolysis ⓘ

AMP↓, 1,   GAPDH↓, 1,   GlucoseCon↓, 1,   GlucoseCon↑, 1,   Glycolysis↓, 2,   HK2↓, 1,   lactateProd↓, 1,   lactateProd↑, 1,   NADPH↓, 1,   p‑PDH↓, 1,   PDKs↓, 1,   PI3K/Akt↓, 1,   SREBP1↓, 1,  

Cell Death ⓘ

Akt↓, 1,   Akt↑, 1,   Apoptosis↑, 6,   BAX↑, 4,   Bcl-2↓, 2,   Casp↑, 1,   Casp3↑, 3,   cl‑Casp3↑, 2,   Casp8↑, 1,   Casp9↑, 2,   cl‑Casp9↑, 1,   Cyt‑c↑, 3,   FADD↑, 1,   Fas↑, 1,   FasL↑, 1,   Ferroptosis↑, 1,   p27↑, 1,   PUMA↑, 1,   survivin↓, 2,   TumCD↑, 1,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   ER Stress↑, 1,   HSP90↓, 2,  

Autophagy & Lysosomes ⓘ

LC3II↑, 1,   p62↓, 1,   TumAuto↑, 2,  

DNA Damage & Repair ⓘ

p16↑, 1,   cl‑PARP↑, 2,  

Cell Cycle & Senescence ⓘ

CDK4↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   TumCCA↑, 5,  

Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 1,   EMT↓, 1,   ERK↓, 1,   mTOR↓, 1,   PI3K↑, 1,   STAT3↓, 1,   TumCG↓, 6,   Wnt↓, 1,  

Migration ⓘ

E-cadherin↑, 1,   MMP2↓, 1,   MMP9↓, 3,   TumCI↓, 3,   TumCMig↓, 1,   TumCP↓, 3,   TumMeta↓, 1,   uPA↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 3,   Hif1a↓, 1,   Hif1a↑, 1,   VEGF↓, 2,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   CXCR4↓, 1,   IKKα↓, 1,   IL1β↓, 1,   IL6↓, 1,   IL8↓, 1,   Imm↑, 1,   Imm↝, 1,   Inflam↓, 1,   NF-kB↓, 4,   NK cell↑, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   BioAv↝, 3,   ChemoSen↑, 5,   Dose?, 1,   Dose↝, 2,   Dose∅, 1,   eff↓, 4,   eff↑, 12,   eff↝, 2,   Half-Life↓, 1,   RadioS↑, 2,   selectivity↑, 2,  

Clinical Biomarkers ⓘ

Ferritin↓, 1,   IL6↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   AntiTum↑, 2,   CardioT↑, 1,   ChemoSideEff↓, 1,   cognitive↑, 1,   hepatoP↓, 1,   neuroP↑, 1,   OS↑, 2,   OS∅, 1,   QoL↑, 1,   Risk↓, 2,   Risk↑, 1,   Risk∅, 1,   toxicity↓, 4,   toxicity↑, 11,   toxicity↝, 2,   toxicity∅, 1,  
Total Targets: 128

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 3,   Catalase↑, 1,   GSH↑, 1,   GSSG∅, 1,   lipid-P↓, 1,   NADPH/NADP+↑, 1,   ROS↓, 2,   ROS↑, 1,   ROS⇅, 1,   SOD↓, 1,   SOD↑, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 1,  

Core Metabolism/Glycolysis ⓘ

12LOX↓, 1,   glucoNG↓, 1,   Glycolysis↑, 1,   NH3↑, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↓, 1,  

Angiogenesis & Vasculature ⓘ

NO↑, 1,  

Barriers & Transport ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   IL6↑, 1,   Inflam↓, 3,   TNF-α↓, 1,  

Synaptic & Neurotransmission ⓘ

BDNF↑, 1,   tau↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 3,   BioAv↑, 3,   Dose?, 1,   Dose↑, 1,   Dose⇅, 1,   Dose↝, 2,   eff↑, 1,  

Clinical Biomarkers ⓘ

IL6↑, 1,  

Functional Outcomes ⓘ

AntiAge↑, 1,   cognitive↑, 1,   memory↑, 1,   neuroP↑, 2,   Strength↑, 1,   toxicity↓, 1,   toxicity↑, 14,   toxicity↝, 2,  
Total Targets: 42

Scientific Paper Hit Count for: toxicity, toxicity
3 3-bromopyruvate
2 5-Hydroxytryptophan
2 Chemotherapy
1 Anti-oxidants
1 Artemisinin
1 beta-glucans
1 Berberine
1 Celastrol
1 Deguelin
1 Disulfiram
1 Copper and Cu NanoParticles
1 Emodin
1 Fisetin
1 Shilajit/Fulvic Acid
1 Honokiol
1 Luteolin
1 Apigenin (mainly Parsley)
1 EGCG (Epigallocatechin Gallate)
1 Resveratrol
1 Propolis -bee glue
1 Piperlongumine
1 Selenium
1 chitosan
1 Selenite (Sodium)
1 Aflavin-3,3′-digallate
1 Vitamin B1/Thiamine
1 Dichloroacetate
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1025  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

Home Page