GSH/GSSG Cancer Research Results

GSH/GSSG, GSH/GSSG ratio: Click to Expand ⟱
Source:
Type:
Glutathione (GSH) is a ubiquitous tripeptide antioxidant that plays a key role in mitigating oxidative damage. GSH is oxidized by ROS to form a homodimer disulfide (GSSG).
The ratio between GSH and GSSG can be used as a metric to define the redox state of a cell, and imbalances in this ratio leading to excess GSSG can cause cell death.
GSH/GSSG ratio can be altered in various types of cancer, including breast, lung, colon, and prostate cancer. In general, increased GSH levels and decreased GSSG levels are associated with cancer progression and poor prognosis.
Scientific Papers found: Click to Expand⟱
1987- PTL,  Rad,    A NADPH oxidase dependent redox signaling pathway mediates the selective radiosensitization effect of parthenolide in prostate cancer cells
- in-vitro, Pca, PC3 - in-vitro, Nor, PrEC
selectivity↑, RadioS↑, ROS↑, *ROS∅, NADPH↑, Trx↓, PI3K↑, Akt↑, p‑FOXO3↓, SOD2↓, Catalase↓, radioP↑, *NADPH∅, *GSH↑, *GSH/GSSG↑, *NRF2↑,
2134- TQ,    Modulation of Nrf2/HO1 Pathway by Thymoquinone to Exert Protection Against Diazinon-induced Myocardial Infarction in Rats
- in-vivo, Nor, NA
*ALAT↓, *AST↓, *MDA↓, *ROS↓, *GSSG↓, *GSH↑, *VitE↑, *VitC↑, *NRF2↑, *HO-1↑, *NQO1↑, *SOD↑, *cardioP↑, *GSH/GSSG↑, *GPx↑,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Catalase↓, 1,   ROS↑, 1,   SOD2↓, 1,   Trx↓, 1,  

Core Metabolism/Glycolysis ⓘ

NADPH↑, 1,  

Cell Death ⓘ

Akt↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

p‑FOXO3↓, 1,   PI3K↑, 1,  

Drug Metabolism & Resistance ⓘ

RadioS↑, 1,   selectivity↑, 1,  

Functional Outcomes ⓘ

radioP↑, 1,  
Total Targets: 11

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

GPx↑, 1,   GSH↑, 2,   GSH/GSSG↑, 2,   GSSG↓, 1,   HO-1↑, 1,   MDA↓, 1,   NQO1↑, 1,   NRF2↑, 2,   ROS↓, 1,   ROS∅, 1,   SOD↑, 1,   VitC↑, 1,   VitE↑, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1,   NADPH∅, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   AST↓, 1,  

Functional Outcomes ⓘ

cardioP↑, 1,  
Total Targets: 18

Scientific Paper Hit Count for: GSH/GSSG, GSH/GSSG ratio
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:104  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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