MMP9:TIMP1 Cancer Research Results

MMP9:TIMP1, MMP-9/TIMP-1 ratio: Click to Expand ⟱
Source:
Type:
The balance between matrix metalloproteinase-9 (MMP-9) and its inhibitor, tissue inhibitor of metalloproteinases-1 (TIMP-1), is critical in regulating extracellular matrix remodeling.
A high MMP-9/TIMP-1 ratio—reflecting either elevated MMP-9 levels, reduced TIMP-1 levels, or both—has been consistently associated with increased invasiveness, metastasis, and poorer prognosis in multiple cancer types including breast, lung, and colorectal cancers.

• This ratio is being explored as a potential biomarker for tumor aggressiveness and may aid in patient stratification, treatment decision-making, and monitoring therapeutic responses.

For sepsis:
Although both MMP-9 and TIMP-1 levels were found equally elevated in sepsis, a decrease in the MMP-9/TIMP-1 ratio is significantly associated with severity and mortality.
Scientific Papers found: Click to Expand⟱
1220- VitC,  VitB1/Thiamine,    The Effect of Thiamine, Ascorbic Acid, and the Combination of Them on the Levels of Matrix Metalloproteinase-9 (MMP-9) and Tissue Inhibitor of Matrix Metalloproteinase-1 (TIMP-1) in Sepsis Patients
- Trial, Sepsis, NA
MMP9:TIMP1↑, Sepsis↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Migration ⓘ

MMP9:TIMP1↑, 1,  

Infection & Microbiome ⓘ

Sepsis↓, 1,  
Total Targets: 2

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: MMP9:TIMP1, MMP-9/TIMP-1 ratio
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1049  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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