ERK Cancer Research Results

ERK, ERK signaling: Click to Expand ⟱
Source:
Type:
MAPK3 (ERK1)
ERK proteins are kinases that activate other proteins by adding a phosphate group. An overactivation of these proteins causes the cell cycle to stop.
The extracellular signal-regulated kinase (ERK) signaling pathway is a crucial component of the mitogen-activated protein kinase (MAPK) signaling cascade, which plays a significant role in regulating various cellular processes, including proliferation, differentiation, and survival. high levels of phosphorylated ERK (p-ERK) in tumor samples may indicate active ERK signaling and could correlate with aggressive tumor behavior

EEk singaling is frequently activated and is often associated with aggressive tumor behavior, treatment resistance, and poor outcomes.
Scientific Papers found: Click to Expand⟱
2288- AgNPs,    Silver Nanoparticle-Mediated Cellular Responses in Various Cell Lines: An in Vitro Model
- Review, Var, NA
*ROS↑, Akt↓, ERK↓, DNAdam↑, Ca+2↑, ROS↑, MMP↓, Cyt‑c↑, TumCCA↑, DNAdam↑, Apoptosis↑, P53↑, p‑ERK↑, ER Stress↑, cl‑ATF6↑, GRP78/BiP↑, CHOP↑, UPR↑,
248- AL,    Allicin inhibits cell growth and induces apoptosis in U87MG human glioblastoma cells through an ERK-dependent pathway
- in-vitro, GBM, U87MG
Bcl-2↓, BAX↑, MAPK↑, ERK↑, ROS↑, p38↑, JNK↑,
235- AL,    Allicin inhibits cell growth and induces apoptosis in U87MG human glioblastoma cells through an ERK-dependent pathway
- in-vitro, GBM, U87MG
Apoptosis↑, Bcl-2↓, BAX↑, MAPK↑, p‑ERK↑, ROS↑, eff↓,
3272- ALA,    Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential
- Review, AD, NA
*antiOx↑, *glucose↑, *eNOS↑, *NRF2↑, *MMP9↓, *VCAM-1↓, *NF-kB↓, *cardioP↑, *cognitive↑, *eff↓, *BBB↑, *IronCh↑, *GSH↑, *PKCδ↑, *ERK↑, *p38↑, *MAPK↑, *PI3K↑, *Akt↑, *PTEN↓, *AMPK↑, *GLUT4↑, *GLUT1↑, *Inflam↓,
3539- ALA,    Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential
- Review, AD, NA
*ROS↓, *IronCh↑, *GSH↑, *antiOx↑, *NRF2↑, *MMP9↓, *VCAM-1↓, *NF-kB↓, *cognitive↑, *Inflam↓, *BioAv↝, *BioAv↝, *BBB↑, *H2O2∅, *neuroP↑, *PKCδ↑, *ERK↑, *MAPK↑, *PI3K↑, *Akt↑, *PTEN↓, *AMPK↑, *GLUT4↑, *GlucoseCon↑, *BP↝, *eff↑, *ICAM-1↓, *VCAM-1↓, *Dose↝,
3549- ALA,    Important roles of linoleic acid and α-linolenic acid in regulating cognitive impairment and neuropsychiatric issues in metabolic-related dementia
- Review, AD, NA
*Inflam↓, *other↝, *other↝, *neuroP↑, *BioAv↝, *adiP↑, *BBB↑, *Casp6↓, *Casp9↓, *TNF-α↓, *IL6↓, *IL1β↓, *ROS↓, *NO↓, *iNOS↓, *COX2↓, *JNK↓, *p‑NF-kB↓, *Aβ↓, *BP↓, *memory↑, *cAMP↑, *ERK↑, *Akt↑, cognitive?,
3884- Api,    Neuroprotective, Anti-Amyloidogenic and Neurotrophic Effects of Apigenin in an Alzheimer’s Disease Mouse Model
- in-vivo, AD, NA
*memory↑, *Aβ↓, *BACE↓, *antiOx↑, *BDNF↑, *p‑CREB↑, *p‑ERK↑, *ROS↓, *SOD↑, *GPx↑, *neuroP↑,
4278- ART/DHA,    Artemisinin Ameliorates the Neurotoxic Effect of 3-Nitropropionic Acid: A Possible Involvement of the ERK/BDNF/Nrf2/HO-1 Signaling Pathway
- in-vivo, NA, NA
*IL6↓, *Casp3↓, *Casp9↓, *BDNF↑, *ERK↑, *NRF2↑, *HO-1↑, *neuroP↑, *antiOx↑, *Inflam↓,
3163- Ash,  Rad,    Withaferin A, a steroidal lactone, selectively protects normal lymphocytes against ionizing radiation induced apoptosis and genotoxicity via activation of ERK/Nrf-2/HO-1 axis
*radioP↑, selectivity↑, *Casp3↓, *DNAdam↓, *ROS↓, *GSH↓, *NRF2↑, *HO-1↑, *Catalase↑, *SOD↑, *Prx↑, *ERK↑,
4276- BA,    Baicalin Attenuates Oxygen–Glucose Deprivation/Reoxygenation–Induced Injury by Modulating the BDNF-TrkB/PI3K/Akt and MAPK/Erk1/2 Signaling Axes in Neuron–Astrocyte Cocultures
- in-vivo, Stroke, NA
*BDNF↑, *neuroP↑, *TrkB↑, *PI3K↑, *Akt↑, *MAPK↑, *ERK↑, *NO↓, *MDA↓, *SOD↑, *TNF-α↓, *IL1β↓, *IL6?,
2480- Ba,    Inhibition of 12/15 lipoxygenase by baicalein reduces myocardial ischemia/reperfusion injury via modulation of multiple signaling pathways
- in-vivo, Stroke, NA
*12LOX↓, *ROS↓, *ERK↑, *Akt↑, *p38↓, *JNK↓, *NF-kB↓, *cardioP↑,
2624- Ba,    Baicalein inhibition of hydrogen peroxide-induced apoptosis via ROS-dependent heme oxygenase 1 gene expression
- in-vitro, Nor, RAW264.7
*HO-1↑, *ERK↑, *ROS↓, *eff↑, *MMP↑, *Cyt‑c∅,
2598- Ba,    Baicalein inhibits melanogenesis through activation of the ERK signaling pathway
- in-vitro, Melanoma, B16-F10
other↓, other?, ERK↑,
1382- BBR,    Berberine increases the expression of cytokines and proteins linked to apoptosis in human melanoma cells
- in-vitro, Melanoma, SK-MEL-28
Apoptosis↑, necrosis↑, DNAdam↑, TumCCA↑, ROS↑, Casp3↑, p‑P53↑, ERK↑,
2690- BBR,    Berberine Differentially Modulates the Activities of ERK, p38 MAPK, and JNK to Suppress Th17 and Th1 T Cell Differentiation in Type 1 Diabetic Mice
- in-vivo, Diabetic, NA
*Inflam↓, *Th17↓, *Th1 response↓, *ERK↑, *p38↓, *JNK↓, *STAT1↓, *STAT4↓, *MAPK↓,
2691- BBR,    Berberine induces FasL-related apoptosis through p38 activation in KB human oral cancer cells
- in-vitro, Oral, KB
tumCV↓, DNAdam↑, Casp3↑, Casp7↑, FasL↑, Casp8↑, Casp9↑, PARP↑, BAX↑, BAD↑, APAF1↑, MMP2↓, MMP9↓, p‑p38↑, ERK↑, MAPK↑,
3678- BBR,    Network pharmacology study on the mechanism of berberine in Alzheimer’s disease model
- Review, AD, NA
*APP↓, *PPARγ↑, *NF-kB↓, *Aβ↓, *cognitive↑, *antiOx↑, *Inflam↓, *Apoptosis↓, *BioAv↑, *BioAv↝, *BBB↑, *motorD↑, *NRF2↑, *HO-1↑, *ROS↓, *p‑Akt↑, *p‑ERK↑,
3680- BBR,    Network pharmacology reveals that Berberine may function against Alzheimer’s disease via the AKT signaling pathway
- in-vivo, AD, NA
*Akt↑, *neuroP↑, *p‑ERK↑, *Aβ↓, *Inflam↓, *ROS↓, *BioAv↑, *BBB↑, *Half-Life↝, *memory↑, *cognitive↑, *HSP90↑, *APP↓, *mTOR↓, *P70S6K↓, *CD31↑, *VEGF↑, *N-cadherin↑, *Apoptosis↓,
5482- BM,    Bacopa monnieri protects SH-SY5Y cells against tert-Butyl hydroperoxide-induced cell death via the ERK and PI3K pathways
- in-vitro, Nor, NA
*neuroP↑, *ERK↑, *Akt↑, *MAPK↑, *PI3K↑, *Inflam↓, antiOx↑,
5693- BRU,    Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity-implications for therapeutic targeting of Nrf2
- in-vivo, HCC, NA
NRF2↓, eff↑, p‑MAPK↑, p‑Akt↑, p‑ERK↑, p‑JNK↑,
1651- CA,  PBG,    Caffeic acid and its derivatives as potential modulators of oncogenic molecular pathways: New hope in the fight against cancer
- Review, Var, NA
Apoptosis↑, TumCCA↓, TumCMig↓, TumMeta↓, ChemoSen↑, eff↑, eff↑, eff↓, eff↝, Dose∅, AMPK↑, p62↓, LC3II↑, Ca+2↑, Bax:Bcl2↑, CDK4↑, CDK6↑, RB1↑, EMT↓, E-cadherin↑, Vim↓, β-catenin/ZEB1↓, NF-kB↓, angioG↑, VEGF↓, TSP-1↑, MMP9↓, MMP2↓, ChemoSen↑, eff↑, ROS↑, CSCs↓, Fas↑, P53↑, BAX↑, Casp↑, β-catenin/ZEB1↓, NDRG1↑, STAT3↓, MAPK↑, ERK↑, eff↑, eff↑, eff↑,
6010- CGA,    The Biological Activity Mechanism of Chlorogenic Acid and Its Applications in Food Industry: A Review
- Review, Nor, NA
*antiOx↑, *hepatoP↑, *RenoP↑, AntiTum↑, *glucose↝, *Inflam↓, *neuroP↑, *ROS↓, *Keap1↓, *NRF2↑, *SOD↑, *Catalase↑, *GPx↑, *GSH↑, *MDA↓, *p‑ERK↑, *GRP78/BiP↑, *CHOP↑, *GRP94↑, *Casp3↓, *Casp9↓, *HGF/c-Met↑, *TNF-α↓, *TLR4↓, *MAPK↓, *IL1β↓, *iNOS↓, TCA↓, Glycolysis↓, Bcl-2↓, BAX↑, MAPK↑, JNK↑, CSCs↓, Nanog↓, SOX2↓, CD44↓, OCT4↓, P53↑, P21↑, *SOD1↑, *AGEs↓, *GLUT2↑, *HDL↑, *Fas↓, *HMG-CoA↓, *NF-kB↓, *HO-1↓, *COX2↓, *TLR4↓, *BioAv↑, *BioAv↝, TumCP↓, TumCMig↓, TumCI↓,
2795- CHr,    Combination of chrysin and cisplatin promotes the apoptosis of Hep G2 cells by up-regulating p53
- in-vitro, Liver, HepG2
ChemoSen↑, P53↑, ERK↑, BAX↑, DR5↑, Bcl-2↓, Casp8↑, Cyt‑c↑, Casp9↑,
2791- CHr,    Chrysin attenuates progression of ovarian cancer cells by regulating signaling cascades and mitochondrial dysfunction
- in-vitro, Ovarian, OV90
TumCP↓, TumCD↑, ROS↑, Ca+2↑, MMP↓, MAPK↑, PI3K↑, p‑Akt↑, PCNA↓, p‑p70S6↑, p‑ERK↑, p38↑, JNK↑, DNAdam↑, TumCCA↑, chemoP↑,
1980- CUR,  Rad,    Thioredoxin reductase-1 (TxnRd1) mediates curcumin-induced radiosensitization of squamous carcinoma cells
- in-vitro, Cerv, HeLa - in-vitro, Laryn, FaDu
selectivity↑, RadioS↑, TrxR↓, ROS↑, ERK↑, Dose∅, cl‑PARP↑,
4175- CUR,    Effects of curcumin on learning and memory deficits, BDNF, and ERK protein expression in rats exposed to chronic unpredictable stress
- in-vivo, NA, NA
*BDNF↑, *ERK↑,
144- CUR,  Bical,    Combination of curcumin and bicalutamide enhanced the growth inhibition of androgen-independent prostate cancer cells through SAPK/JNK and MEK/ERK1/2-mediated targeting NF-κB/p65 and MUC1-C
- in-vitro, Pca, PC3 - in-vitro, PC, DU145 - in-vitro, PC, LNCaP
p‑ERK↑, p‑JNK↓, MUC1↓, p65↓, AR↓, TumCG↓, MEK↑, SAPK↑,
463- CUR,    Curcumin induces autophagic cell death in human thyroid cancer cells
- in-vitro, Thyroid, K1 - in-vitro, Thyroid, FTC-133 - in-vitro, Thyroid, BCPAP - in-vitro, Thyroid, 8505C
TumAuto↑, LC3II↑, Beclin-1↑, p‑p38↑, p‑JNK↑, p‑ERK↑, p62↓, p‑PDK1↓, p‑Akt↓, p‑p70S6↓, p‑PIK3R1↓, p‑S6↓, p‑4E-BP1↓,
462- CUR,    Curcumin promotes cancer-associated fibroblasts apoptosis via ROS-mediated endoplasmic reticulum stress
- in-vitro, Pca, PC3
Bcl-2↓, MMP↓, cl‑Casp3↑, BAX↑, BIM↑, p‑PARP↑, PUMA↑, p‑P53↑, ROS↑, p‑ERK↑, p‑eIF2α↑, CHOP↑, ATF4↑,
2821- CUR,    Antioxidant curcumin induces oxidative stress to kill tumor cells (Review)
- Review, Var, NA
*antiOx↑, *NRF2↑, *ROS↓, *Inflam↓, ROS↑, p‑ERK↑, ER Stress↑, mtDam↑, Apoptosis↑, Akt↓, mTOR↓, HO-1↑, Fenton↑, GSH↓, Iron↑, p‑JNK↑, Cyt‑c↑, ATF6↑, CHOP↑,
670- EGCG,    Epigallocatechin-3-gallate and its nanoformulation in cervical cancer therapy: the role of genes, MicroRNA and DNA methylation patterns
- Review, NA, NA
TumCCA↑, P53↑, ERK↓, EGFR↓, p‑ERK↑, VEGF↓, Hif1a↓, miR-203↓, miR-210↑,
1303- EGCG,    (-)-Epigallocatechin-3-gallate induces apoptosis in human endometrial adenocarcinoma cells via ROS generation and p38 MAP kinase activation
- in-vitro, EC, NA
TumCP↓, ER-α36↓, cycD1/CCND1↓, ERK↑, Jun↓, BAX↑, Bcl-2↓, cl‑Casp3↑, ROS↑, p38↑,
1654- FA,    Molecular mechanism of ferulic acid and its derivatives in tumor progression
- Review, Var, NA
AntiCan↑, Inflam↓, RadioS↑, ROS↑, Apoptosis↑, TumCCA↑, TumCMig↑, TumCI↓, angioG↓, ChemoSen↑, ChemoSideEff↓, P53↑, cycD1/CCND1↓, CDK4↓, CDK6↓, TumW↓, miR-34a↑, Bcl-2↓, Casp3↑, BAX↑, β-catenin/ZEB1↓, cMyc↓, Bax:Bcl2↑, SOD↓, GSH↓, LDH↓, ERK↑, eff↑, JAK2↓, STAT6↓, NF-kB↓, PYCR1↓, PI3K↓, Akt↓, mTOR↓, Ki-67↓, VEGF↓, FGFR1↓, EMT↓, CAIX↓, LC3II↑, p62↑, PKM2↓, Glycolysis↓, *BioAv↓,
3712- FA,    Ferulic Acid: A Hope for Alzheimer’s Disease Therapy from Plants
- Review, AD, NA
*antiOx↑, *Inflam↓, *ROS↓, *Aβ↓, *HO-1↑, *HSP70/HSPA5↑, *ERK↑, *Akt↑, *iNOS↓, *COX2↓, *cardioP↑, *memory↑, *IL2↓, *cognitive↑, *APP↓, *SOD↑, *Catalase↑, *Akt↑, *BioAv↑,
2850- FIS,    Fisetin regulates TPA-induced breast Cancer cell invasion by suppressing matrix metalloproteinase-9 activation via the PKC/ROS/MAPK pathways
- in-vitro, BC, MCF-7
TumCI↓, PKCδ↓, ROS↓, ERK↑, p38↓, NF-kB↓, MMP9↓,
2825- FIS,    Exploring the molecular targets of dietary flavonoid fisetin in cancer
- Review, Var, NA
*Inflam↓, *antiOx↓, *ERK↑, *p‑cMyc↑, *NRF2↑, *GSH↑, *HO-1↑, mTOR↓, PI3K↓, Akt↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, P21↑, p27↑, JNK↑, MMP2↓, MMP9↓, uPA↓, NF-kB↓, cFos↓, cJun↓, E-cadherin↑, Vim↓, N-cadherin↓, EMT↓, MMP↓, Cyt‑c↑, Diablo↑, Casp↑, cl‑PARP↑, P53↑, COX2↓, PGE2↓, HSP70/HSPA5↓, HSP27↓, DNAdam↑, Casp3↑, Casp9↑, ROS↑, AMPK↑, NO↑, Ca+2↑, mTORC1↓, p70S6↓, ROS↓, ER Stress↑, IRE1↑, ATF4↑, GRP78/BiP↑, eff↑, eff↑, eff↑, RadioS↑, ChemoSen↑, Half-Life↝,
4250- Flav,    Dietary Flavonoids Interaction with CREB-BDNF Pathway: An 
Unconventional Approach for Comprehensive Management of Epilepsy
- Review, NA, NA
*ERK↑, *BDNF↑, *CREB↑,
1971- GamB,    Gambogic acid triggers vacuolization-associated cell death in cancer cells via disruption of thiol proteostasis
- in-vitro, Nor, MCF10 - in-vitro, BC, MDA-MB-435 - in-vitro, BC, MDA-MB-468 - in-vivo, NA, NA
Paraptosis↑, ER Stress↑, MMP↓, eff↓, selectivity↑, p‑ERK↑, p‑JNK↑, eff↓,
4302- Gins,    Panax ginseng: A modulator of amyloid, tau pathology, and cognitive function in Alzheimer's disease
- Review, AD, NA
*neuroP↑, *Aβ↓, *p‑tau↓, *cognitive↑, *eff↑, *PKA↑, *CREB↑, *BACE↓, *ADAM10↑, *MAPK↑, *ERK↑, *PI3K↑, *Akt↑, *NRF2↑, *PPARγ↓, *IDE↑, *APP↓, *PP2A↑, *memory↑,
4343- H2,    Inhibitory effects of hydrogen on in vitro platelet activation and in vivo prevention of thrombosis formation
- vitro+vivo, NA, NA
*antiOx↑, *AntiAg↑, *NO↑, *ERK↑,
2073- HNK,    Honokiol induces apoptosis and autophagy via the ROS/ERK1/2 signaling pathway in human osteosarcoma cells in vitro and in vivo
- in-vitro, OS, U2OS - in-vivo, NA, NA
TumCD↑, TumAuto↑, Apoptosis↑, TumCCA↑, GRP78/BiP↑, ROS↑, eff↓, p‑ERK↑, selectivity↑, Ca+2↑, MMP↓, Casp3↑, Casp9↑, cl‑PARP↑, Bcl-2↓, Bcl-xL↓, survivin↓, LC3B-II↑, ATG5↑, TumVol↓, TumW↓, ER Stress↑,
2869- HNK,    Nature's neuroprotector: Honokiol and its promise for Alzheimer's and Parkinson's
- Review, AD, NA - Review, Park, NA
*neuroP↑, *Inflam↓, *motorD↑, *Aβ↓, *p‑tau↓, *cognitive↑, *memory↑, *ERK↑, *p‑Akt↑, *PPARγ↑, *PGC-1α↑, *MMP↑, *mt-ROS↓, *SIRT3↑, *IL1β↓, *TNF-α↓, *GRP78/BiP↓, *CHOP↓, *NF-kB↓, *GSK‐3β↓, *β-catenin/ZEB1↑, *Ca+2↓, *AChE↓, *SOD↑, *Catalase↑, *GPx↑,
4213- Hup,    Huperzine A-Liposomes Efficiently Improve Neural Injury in the Hippocampus of Mice with Chronic Intermittent Hypoxia
- in-vivo, NA, NA
*cognitive↑, *SOD↑, *GPx↑, *MDA↓, *ROS↓, *Iron↓, *TfR1/CD71↓, *FTL↓, *ERK↑, *PKA↑, *CREB↑, *BDNF↑, *PSD95↑, *neuroP↑,
2923- LT,    Luteolin induces apoptosis through endoplasmic reticulum stress and mitochondrial dysfunction in Neuro-2a mouse neuroblastoma cells
- in-vitro, NA, NA
Apoptosis↑, TumCD↑, Casp12↑, Casp9↑, Casp3↑, ER Stress↑, CHOP↑, GRP78/BiP↑, GRP94↑, cl‑ATF6↑, p‑eIF2α↑, MMP↓, JNK↓, p38↑, ERK↑, Cyt‑c↑,
4786- Lyco,    Anti-proliferative and apoptosis-inducing activity of lycopene against three subtypes of human breast cancer cell lines
- in-vitro, BC, MDA-MB-468 - in-vitro, BC, MCF-7 - in-vitro, BC, SkBr3
TumCP↓, TumCCA↑, cl‑PARP↑, ERK↑, cycD1/CCND1↓, P21↓, p‑Akt↓, mTOR↓, BAX↑, AntiCan↑, Risk↓,
2243- MF,    Pulsed electromagnetic fields increase osteogenetic commitment of MSCs via the mTOR pathway in TNF-α mediated inflammatory conditions: an in-vitro study
- in-vitro, Nor, NA
*eff↑, *mTOR↑, *Akt↑, *PKA↑, *MAPK↑, *ERK↑, *BMP2↑, *Diff↑, *PKCδ↓, *VEGF↑, *IL10↑,
4146- MF,    Pulsed electromagnetic field enhances brain-derived neurotrophic factor expression through L-type voltage-gated calcium channel- and Erk-dependent signaling pathways in neonatal rat dorsal root ganglion neurons
- in-vivo, AD, NA
*BDNF↑, *ERK↑,
527- MF,    Effects of Fifty-Hertz Electromagnetic Fields on Granulocytic Differentiation of ATRA-Treated Acute Promyelocytic Leukemia NB4 Cells
- in-vitro, AML, APL NB4
ROS↑, other↑, p‑ERK↑, TumCP↓,
486- MF,    mTOR Activation by PI3K/Akt and ERK Signaling in Short ELF-EMF Exposed Human Keratinocytes
- in-vitro, Nor, HaCaT
*mTOR↑, *PI3K↑, *Akt↑, *p‑ERK↑, *other↑, *p‑JNK↑, *p‑P70S6K↑,
513- MF,    Exposure to a specific time-varying electromagnetic field inhibits cell proliferation via cAMP and ERK signaling in cancer cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468 - in-vitro, BC, MCF-7 - in-vivo, Pca, HeLa
TumCG↓, p‑ERK↑, cAMP⇅,

Showing Research Papers: 1 to 50 of 80
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 80

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Fenton↑, 1,   GSH↓, 2,   HO-1↑, 1,   Iron↑, 1,   NRF2↓, 1,   PYCR1↓, 1,   ROS↓, 2,   ROS↑, 14,   SOD↓, 1,   TrxR↓, 1,  

Mitochondria & Bioenergetics ⓘ

FGFR1↓, 1,   MEK↑, 1,   MMP↓, 7,   mtDam↑, 1,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 2,   CAIX↓, 1,   cAMP⇅, 1,   cMyc↓, 1,   Glycolysis↓, 2,   LDH↓, 1,   p‑PDK1↓, 1,   p‑PIK3R1↓, 1,   PKM2↓, 1,   p‑S6↓, 1,   TCA↓, 1,  

Cell Death ⓘ

Akt↓, 4,   p‑Akt↓, 2,   p‑Akt↑, 2,   APAF1↑, 1,   Apoptosis↑, 8,   BAD↑, 1,   BAX↑, 10,   Bax:Bcl2↑, 2,   Bcl-2↓, 8,   Bcl-xL↓, 1,   BIM↑, 1,   Casp↑, 2,   Casp12↑, 1,   Casp3↑, 6,   cl‑Casp3↑, 2,   Casp7↑, 1,   Casp8↑, 2,   Casp9↑, 5,   Cyt‑c↑, 5,   Diablo↑, 1,   DR5↑, 1,   Fas↑, 1,   FasL↑, 1,   JNK↓, 1,   JNK↑, 4,   p‑JNK↓, 1,   p‑JNK↑, 4,   MAPK↑, 6,   p‑MAPK↑, 1,   necrosis↑, 1,   p27↑, 1,   p38↓, 1,   p38↑, 4,   p‑p38↑, 2,   Paraptosis↑, 1,   PUMA↑, 1,   survivin↓, 1,   TumCD↑, 3,  

Kinase & Signal Transduction ⓘ

p70S6↓, 1,   p‑p70S6↓, 1,   p‑p70S6↑, 1,  

Transcription & Epigenetics ⓘ

cJun↓, 1,   other?, 1,   other↓, 1,   other↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress ⓘ

ATF6↑, 1,   cl‑ATF6↑, 2,   CHOP↑, 4,   p‑eIF2α↑, 2,   ER Stress↑, 6,   GRP78/BiP↑, 4,   GRP94↑, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 1,   IRE1↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes ⓘ

ATG5↑, 1,   Beclin-1↑, 1,   LC3B-II↑, 1,   LC3II↑, 3,   p62↓, 2,   p62↑, 1,   TumAuto↑, 2,  

DNA Damage & Repair ⓘ

DNAdam↑, 6,   P53↑, 7,   p‑P53↑, 2,   PARP↑, 1,   p‑PARP↑, 1,   cl‑PARP↑, 4,   PCNA↓, 1,   SAPK↑, 1,  

Cell Cycle & Senescence ⓘ

CDK2↓, 1,   CDK4↓, 2,   CDK4↑, 1,   cycD1/CCND1↓, 4,   cycE/CCNE↓, 1,   P21↓, 1,   P21↑, 2,   RB1↑, 1,   TumCCA↓, 1,   TumCCA↑, 8,  

Proliferation, Differentiation & Cell State ⓘ

p‑4E-BP1↓, 1,   CD44↓, 1,   cFos↓, 1,   CSCs↓, 2,   EMT↓, 3,   ERK↓, 2,   ERK↑, 12,   p‑ERK↑, 13,   Jun↓, 1,   miR-34a↑, 1,   mTOR↓, 4,   mTORC1↓, 1,   Nanog↓, 1,   OCT4↓, 1,   PI3K↓, 2,   PI3K↑, 1,   SOX2↓, 1,   STAT3↓, 1,   STAT6↓, 1,   TumCG↓, 2,  

Migration ⓘ

Ca+2↑, 5,   E-cadherin↑, 2,   ER-α36↓, 1,   Ki-67↓, 1,   miR-203↓, 1,   MMP2↓, 3,   MMP9↓, 4,   MUC1↓, 1,   N-cadherin↓, 1,   PKCδ↓, 1,   TSP-1↑, 1,   TumCI↓, 3,   TumCMig↓, 2,   TumCMig↑, 1,   TumCP↓, 5,   TumMeta↓, 1,   uPA↓, 1,   Vim↓, 2,   β-catenin/ZEB1↓, 3,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   angioG↑, 1,   ATF4↑, 2,   EGFR↓, 1,   Hif1a↓, 1,   miR-210↑, 1,   NO↑, 1,   VEGF↓, 3,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   Inflam↓, 1,   JAK2↓, 1,   NF-kB↓, 4,   p65↓, 1,   PGE2↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,   CDK6↓, 2,   CDK6↑, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 5,   Dose∅, 2,   eff↓, 5,   eff↑, 11,   eff↝, 1,   Half-Life↝, 1,   RadioS↑, 3,   selectivity↑, 4,  

Clinical Biomarkers ⓘ

AR↓, 1,   EGFR↓, 1,   Ki-67↓, 1,   LDH↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 2,   AntiTum↑, 1,   chemoP↑, 1,   ChemoSideEff↓, 1,   cognitive?, 1,   NDRG1↑, 1,   Risk↓, 1,   TumVol↓, 1,   TumW↓, 2,  
Total Targets: 185

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   antiOx↑, 9,   Catalase↑, 4,   GPx↑, 4,   GSH↓, 1,   GSH↑, 4,   H2O2∅, 1,   HDL↑, 1,   HO-1↓, 1,   HO-1↑, 6,   Iron↓, 1,   Keap1↓, 1,   MDA↓, 3,   NRF2↑, 9,   Prx↑, 1,   ROS↓, 12,   ROS↑, 1,   mt-ROS↓, 1,   SIRT3↑, 1,   SOD↑, 7,   SOD1↑, 1,  

Metal & Cofactor Biology ⓘ

FTL↓, 1,   IronCh↑, 2,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↑, 2,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis ⓘ

12LOX↓, 1,   adiP↑, 1,   AMPK↑, 2,   cAMP↑, 1,   p‑cMyc↑, 1,   CREB↑, 3,   p‑CREB↑, 1,   glucose↑, 1,   glucose↝, 1,   GlucoseCon↑, 1,   GLUT2↑, 1,   HMG-CoA↓, 1,   PPARγ↓, 1,   PPARγ↑, 2,  

Cell Death ⓘ

Akt↑, 12,   p‑Akt↑, 2,   Apoptosis↓, 2,   BMP2↑, 1,   Casp3↓, 3,   Casp6↓, 1,   Casp9↓, 3,   Cyt‑c∅, 1,   Fas↓, 1,   HGF/c-Met↑, 1,   iNOS↓, 3,   JNK↓, 3,   p‑JNK↑, 1,   MAPK↓, 2,   MAPK↑, 6,   p38↓, 2,   p38↑, 1,  

Transcription & Epigenetics ⓘ

other↑, 1,   other↝, 2,  

Protein Folding & ER Stress ⓘ

CHOP↓, 1,   CHOP↑, 1,   GRP78/BiP↓, 1,   GRP78/BiP↑, 1,   GRP94↑, 1,   HSP70/HSPA5↑, 1,   HSP90↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

Diff↑, 1,   ERK↑, 20,   p‑ERK↑, 5,   GSK‐3β↓, 1,   mTOR↓, 1,   mTOR↑, 2,   P70S6K↓, 1,   p‑P70S6K↑, 1,   PI3K↑, 6,   PTEN↓, 2,   STAT1↓, 1,   STAT4↓, 1,  

Migration ⓘ

AntiAg↑, 1,   APP↓, 4,   Ca+2↓, 1,   CD31↑, 1,   MMP9↓, 2,   N-cadherin↑, 1,   PKA↑, 3,   PKCδ↓, 1,   PKCδ↑, 2,   VCAM-1↓, 3,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature ⓘ

eNOS↑, 1,   NO↓, 2,   NO↑, 1,   VEGF↑, 2,  

Barriers & Transport ⓘ

BBB↑, 5,   GLUT1↑, 1,   GLUT4↑, 2,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 3,   ICAM-1↓, 1,   IL10↑, 1,   IL1β↓, 4,   IL2↓, 1,   IL6?, 1,   IL6↓, 2,   Inflam↓, 13,   NF-kB↓, 6,   p‑NF-kB↓, 1,   Th1 response↓, 1,   Th17↓, 1,   TLR4↓, 2,   TNF-α↓, 4,  

Synaptic & Neurotransmission ⓘ

AChE↓, 1,   ADAM10↑, 1,   BDNF↑, 7,   PSD95↑, 1,   p‑tau↓, 2,   TrkB↑, 1,  

Protein Aggregation ⓘ

AGEs↓, 1,   Aβ↓, 7,   BACE↓, 2,   IDE↑, 1,   PP2A↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 4,   BioAv↝, 5,   Dose↝, 1,   eff↓, 1,   eff↑, 4,   Half-Life↝, 1,  

Clinical Biomarkers ⓘ

BP↓, 1,   BP↝, 1,   IL6?, 1,   IL6↓, 2,  

Functional Outcomes ⓘ

cardioP↑, 3,   cognitive↑, 8,   hepatoP↑, 1,   memory↑, 6,   motorD↑, 2,   neuroP↑, 11,   radioP↑, 1,   RenoP↑, 1,  
Total Targets: 141

Scientific Paper Hit Count for: ERK, ERK signaling
7 Magnetic Fields
6 Curcumin
5 Berberine
5 Sulforaphane (mainly Broccoli)
3 Alpha-Lipoic-Acid
3 Baicalein
3 Quercetin
3 Shikonin
3 Thymoquinone
2 Allicin (mainly Garlic)
2 Radiotherapy/Radiation
2 Propolis -bee glue
2 Chrysin
2 EGCG (Epigallocatechin Gallate)
2 Ferulic acid
2 Fisetin
2 Honokiol
2 Pterostilbene
2 Vitamin K2
1 Silver-NanoParticles
1 Apigenin (mainly Parsley)
1 Artemisinin
1 Ashwagandha(Withaferin A)
1 Baicalin
1 Bacopa monnieri
1 brusatol
1 Caffeic acid
1 Chlorogenic acid
1 Bicalutamide
1 flavonoids
1 Gambogic Acid
1 Ginseng
1 Hydrogen Gas
1 Huperzine A/Huperzia serrata
1 Luteolin
1 Lycopene
1 Magnetic Field Rotating
1 Phenylbutyrate
1 Piperine
1 Piperlongumine
1 Plumbagin
1 Cisplatin
1 Salvia officinalis
1 Rosmarinic acid
1 Aromatherapy
1 Salvia miltiorrhiza
1 Aflavin-3,3′-digallate
1 Vitamin C (Ascorbic Acid)
1 Zinc
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:105  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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