HMGB1 Cancer Research Results

HMGB1, High Mobility Group Box 1: Click to Expand ⟱
Source:
Type:
HMGB1 is a nuclear protein that plays key roles in DNA architecture and regulation of transcription; however, when released extracellularly it can act as a damage-associated molecular pattern (DAMP), influencing immune responses and affecting tumor progression.

Overexpression of HMGB1, particularly when associated with increased extracellular release, is frequently correlated with enhanced tumor aggressiveness, metastasis, and poorer survival across several cancer types including breast, colorectal, lung, ovarian, and pancreatic cancers.
• Its critical involvement in inflammation and immune modulation makes HMGB1 an attractive candidate for targeted therapeutic intervention as well as a potential prognostic marker.
Scientific Papers found: Click to Expand⟱
5010- DSF,  Cu,  Rad,    Disulfiram/Copper Combined with Irradiation Induces Immunogenic Cell Death in Melanoma
- in-vivo, Melanoma, B16-F10
Apoptosis↑, DSF/Cu + IR significantly increased the cellular apoptosis and increased ICD markers:
ICD↑,
HMGB1↑, high-mobility group box 1 (HMGB1) release, and decreased intracellular ATP levels. I
ATP↓,
TumCG↓, DSF/Cu combined with IR treatment inhibited tumor growth and enhanced tumor-infiltrating immune cells in the B16F10-bearing C57BL/6 model

7816- ISQ,    Isoquercitrin Induces Endoplasmic Reticulum Stress and Immunogenic Cell Death in Gastric Cancer Cells
- in-vitro, GC, AGS - in-vitro, GC, HGC27
TumCP↑, Isoquercitrin at doses greater than 20 μM had significant inhibitory effects on the survival of GC cell lines, including HGC-27, AGS, MKN-45, and SNU-1.
Bcl-2↓, downregulation of BCL-2 and upregulation of BAX, cleaved caspase-3, and caspase-12.
BAX↑,
cl‑Casp3↑,
Casp12↑,
MMP↓, isoquercitrin promoted the disruption of mitochondrial membrane potential in GC cells.
CRT↑, GC cell surface levels of calreticulin (CRT) and extracellular levels of CRT, ATP, and HMGB1 were enhanced by treatment with isoquercitrin.
e-ATP↑,
HMGB1↑,
HSP70/HSPA5↑, The protein levels of HMGB1, HSP70, and HSP90 were upregulated by isoquercitrin in a dose-dependent manner.
HSP90↑,
ER Stress↑, isoquercitrin induces ER stress and ICD in GC cells.


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ICD↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 1,   e-ATP↑, 1,   MMP↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   Casp12↑, 1,   cl‑Casp3↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CRT↑, 1,   ER Stress↑, 1,   HSP70/HSPA5↑, 1,   HSP90↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 1,  

Migration(tgid=13) ⓘ

TumCP↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

HMGB1↑, 2,  
Total Targets: 16

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: HMGB1, High Mobility Group Box 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1059  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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