CD14 Cancer Research Results

CD14, CD14: Click to Expand ⟱
Source:
Type:
CD14 is a co-receptor that recognizes several ligands, including bacterial lipopolysaccharide (LPS) and other pathogen-associated molecular patterns (PAMPs). It plays a pivotal role in innate immunity by identifying danger signals.
CD14 works in close cooperation with Toll-like receptors (TLRs), especially TLR4.

CD14 is highly expressed in myeloid cells within the tumor microenvironment, such as tumor-associated macrophages (TAMs) and certain dendritic cell subsets.
A high prevalence of CD14⁺ cells within the tumor microenvironment is associated with chronic inflammation, which in turn can contribute to tumor progression, angiogenesis, and eventual metastasis.
Scientific Papers found: Click to Expand⟱
6750- DHA,  Chemo,    Docosahexaenoic acid (DHA) supplementation attenuates changes in the concentration, phenotype, and response of immune peripheral blood cells in breast cancer patients undergoing neoadjuvant therapy. Secondary findings from the DHA-WIN trial
- Trial, BC, NA
*CD14↑, *NLR↓, eff↑, *IL4↑, *IL10↑, *IFN-γ↑, *TNF-α↑, Imm↑, eff↑, TumW↓,
1345- SK,    The Critical Role of Redox Homeostasis in Shikonin-Induced HL-60 Cell Differentiation via Unique Modulation of the Nrf2/ARE Pathway
- in-vitro, AML, HL-60
CD14↑, CD11b↑, ROS↑, GSH↓, GSH/GSSG↓, GPx↑, Catalase↓, Diff↑,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↓, 1,   GPx↑, 1,   GSH↓, 1,   GSH/GSSG↓, 1,   ROS↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Diff↑, 1,  

Migration(tgid=13) ⓘ

CD11b↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD14↑, 1,   Imm↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↑, 2,  

Functional Outcomes(tgid=23) ⓘ

TumW↓, 1,  
Total Targets: 11

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

NLR↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD14↑, 1,   IFN-γ↑, 1,   IL10↑, 1,   IL4↑, 1,   TNF-α↑, 1,  
Total Targets: 6

Scientific Paper Hit Count for: CD14, CD14
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1068  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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