HSF1 Cancer Research Results

HSF1, Heat Shock Factor 1: Click to Expand ⟱
Source:
Type:
HSF1 is the master regulator of the heat shock response. When cells experience stress (e.g., heat, oxidative stress, hypoxia), HSF1 becomes activated and translocates to the nucleus.
– Beyond facilitating the immediate survival response to stress, HSF1 also regulates genes involved in protein folding, degradation, and overall cellular quality control.

Oncogenic Functions:
– In cancer, HSF1 is frequently hijacked to support malignant progression. It can promote several cancer hallmarks including cell proliferation, survival, invasion, and metastasis.
– Elevated HSF1 expression and activity have been observed in various tumor types, including breast, prostate, lung, and colorectal cancers.
– Elevated HSF1 expression/activity is generally associated with poor clinical outcomes, aggressive cancer behavior, and therapeutic resistance.
Scientific Papers found: Click to Expand⟱
3461- RF,    Electromagnetic Field Stimulation Therapy for Alzheimer’s Disease
- Review, AD, NA
*Aβ↓, REMFS activate autophagy pathways in cell cultures [59,95,96] and animal models [88,89], and decreased Aβ levels in both [65,68,80,97]
*HSF1↑, REMFS activates multitarget pathways, including the heat shock factor 1 [43,98], autophagy-lysosome system [61], ubiquitin-proteasome system [60], oxidative stress [62,99], cytoprotection [63], inflammation [100], mitochondrial, and neuronal activity
*ROS↓,
*Inflam↓, REMFS also decreases the expression of β Beta secretase 1 (BACE1) to prevent inflammation
*cognitive↑, to lower Aβ levels and potentially improve cognition in AD patients
*memory↑, hat lowers Aβ [55] in memory areas and potentially stop disease progression [68] and improve memory without brain swelling
*eff↑, 64 MHz has a penetration depth of 13.5 cm [8,155], sufficient to reach the hippocampus and other deep structures affected early in AD for better treatment.

3490- RF,    Multidimensional insights into the repeated electromagnetic field stimulation and biosystems interaction in aging and age-related diseases
- Review, AD, NA - Review, Park, NA
*OS↑, Several short-term exposure studies have shown that REMFS increases lifespan in mice, worms, and flies.
*memory↑, An initial REMFS study prevented or reversed memory loss in Tg AD mouse model (AβPPsw) when a pulsed and modulated RF-EMF at 918 MHz with a SAR of 0.25–1.05 W/kg was applied over a 7 to 9 month period
*cognitive↑, preserved good cognitive function, whereas control Tg mice showed cognitive decline.
*memory↑, REMFS exposure for 2 months showed improved memory in the Y-maze task, although not in more complex tasks
*Aβ↓, 24–30% decrease of Aβ deposits.
*eff↑, lengthier EMF exposures of 1 h, and to a lesser extent 3–24 h, produced biological effects.
*HSF1↑, REMFS activates HSF1 and chaperone expression
*HSP70/HSPA5↑, EMF exposure also increases HSF1-heat shock element binding activity, thereby directly contributing to the activation of HSF1 and the stress-induced Hsp70


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

ROS↓, 1,  

Protein Folding & ER Stress ⓘ

HSF1↑, 2,   HSP70/HSPA5↑, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 2,  

Drug Metabolism & Resistance ⓘ

eff↑, 2,  

Functional Outcomes ⓘ

cognitive↑, 2,   memory↑, 3,   OS↑, 1,  
Total Targets: 9

Scientific Paper Hit Count for: HSF1, Heat Shock Factor 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1072  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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