ChemoSen Cancer Research Results

ChemoSen, chemo-sensitization: Click to Expand ⟱
Source:
Type:
The effectiveness of chemotherapy by increasing cancer cell sensitivity to the drugs used to treat them, which is known as “chemo-sensitization”.

Chemo-Sensitizers:
-Curcumin
-Resveratrol
-EGCG
-Quercetin
-Genistein
-Berberine
-Piperine: alkaloid from black pepper
-Ginsenosides: active components of ginseng
-Silymarin
-Allicin
-Lycopene
-Ellagic acid
-caffeic acid phenethyl ester
-flavopiridol
-oleandrin
-ursolic acid
-butein
-betulinic acid
Scientific Papers found: Click to Expand⟱
2325- 2DG,    Research Progress of Warburg Effect in Hepatocellular Carcinoma
- Review, Var, NA
HK2↓, Glycolysis↓, PKM2↓, LDHA↓, TumCD↑, ChemoSen↑, eff↑,
2423- 2DG,  SRF,    2-Deoxyglucose and sorafenib synergistically suppress the proliferation and motility of hepatocellular carcinoma cells
- in-vitro, HCC, NA
ChemoSen↑, TumCP↓, cycD1/CCND1↓, MMP9↓,
1337- 2DG,  Rad,    2-deoxy-D-glucose causes cytotoxicity, oxidative stress, and radiosensitization in pancreatic cancer
- in-vivo, NA, NA
ChemoSen↑, GlucoseCon↓, ROS↑,
1339- 2DG,  Cisplatin,    2-Deoxy-d-Glucose Combined with Cisplatin Enhances Cytotoxicity via Metabolic Oxidative Stress in Human Head and Neck Cancer Cells
- in-vitro, HNSCC, FaDu
ChemoSen↑, ROS↑, GSH↓, other↓,
5271- 3BP,    The anticancer agent 3-bromopyruvate: a simple but powerful molecule taken from the lab to the bedside
- Review, Var, NA
selectivity↑, selectivity↑, ATP↓, Glycolysis↓, HK2↓, mt-OXPHOS↓, GAPDH↓, mtDam↑, GSH↓, ROS↑, ER Stress↑, TumAuto↑, LC3‑Ⅱ/LC3‑Ⅰ↑, p62↓, Akt↓, HDAC↓, TumCA↑, Bcl-2↓, cMyc↓, Casp3↑, Cyt‑c↑, Mcl-1↓, PARP↓, ChemoSen↑,
5257- 3BP,    Tumor Energy Metabolism and Potential of 3-Bromopyruvate as an Inhibitor of Aerobic Glycolysis: Implications in Tumor Treatment
- Review, Var, NA
Glycolysis↓, mt-OXPHOS↓, HK2↓, Cyt‑c↑, Casp3↓, Bcl-2↓, Mcl-1↓, GAPDH↓, LDH↓, PDH↓, TCA↓, GlutaM↓, GSH↓, ATP↓, mitResp↓, ROS↑, ChemoSen↑, toxicity↝,
5459- AF,    Auranofin Induces Lethality Driven by Reactive Oxygen Species in High-Grade Serous Ovarian Cancer Cells
- in-vitro, Ovarian, NA
ROS↑, TrxR↓, MMP↓, Apoptosis↑, eff↓, Casp3↑, Casp7↑, DNAdam↑, eff↑, GSH↓, angioG↓, ChemoSen↑, cl‑PARP↑, eff↑,
5466- AF,    Auranofin Inhibition of Thioredoxin Reductase in a Preclinical Model of Small Cell Lung Cancer
- in-vivo, Lung, NA
TrxR↓, Dose↝, RadioS↑, ChemoSen↑, ROS↑, Diff↑, toxicity↓,
5462- AF,    Repurposing Auranofin for Oncology and Beyond: A Brief Overview of Clinical Trials as Mono- and Combination Therapy
- Review, Var, NA
AntiTum↑, Bacteria↓, TrxR↓, ChemoSen↑, Dose↝, ROS↑, Apoptosis↑, mTOR↓,
1334- AG,    Astragalus membranaceus: A Review of Its Antitumor Effects on Non-Small Cell Lung Cancer
- Review, NA, NA
TumCP↓, Apoptosis↑, NF-kB↓, p50↓, cycD1/CCND1↓, Bcl-xL↓, ChemoSen↑, angioG↓, ChemoSen↑,
5428- AG,    Meta-Analysis of Astragalus-Containing Traditional Chinese Medicine Combined With Chemotherapy for Colorectal Cancer: Efficacy and Safety to Tumor Response
- Review, CRC, NA
ChemoSen↑, chemoP↑, QoL↑, RenoP∅, hepatoP∅,
5431- AG,    Advances in research on the anti-tumor mechanism of Astragalus polysaccharides
- Review, Var, NA
AntiTum↑, TumCG↓, TumCI↓, Apoptosis↑, Imm↑, Bcl-2↓, BAX↑, Wnt↓, β-catenin/ZEB1↓, TumCG↓, miR-133a-3p↑, JNK↓, Fas↑, P53↑, P21↑, NOTCH1↓, NOTCH3↓, TumCP↓, TumCCA↑, GPx4↓, xCT↓, AMPK↑, Beclin-1↑, NF-kB↓, EMT↓, Vim↓, TumMeta↓, VEGF↓, EGFR↓, eff↑, eff↑, MMP↓, P-gp↓, MMP9↓, ChemoSen↑, SIRT1↓, SREBP1↓, TumAuto↑, PI3K↓, mTOR↓, Casp3↑, Casp9↑, CD133↓, CD44↓, CSCs↓, QoL↑,
5432- AG,    Astragalus polysaccharides combined with radiochemotherapy for cervical cancer: a systematic review and meta-analysis of randomized controlled studies
- Review, Cerv, NA
ChemoSen↑, eff↑, RadioS↑, CEA↓, Wnt↓, β-catenin/ZEB1↓, γH2AX↑, ER Stress↑, mt-TumAuto↑, QoL↑, Imm↑,
5434- AG,    Recent Advances in the Mechanisms and Applications of Astragalus Polysaccharides in Liver Cancer Treatment: An Overview
- Review, Liver, NA
AntiCan↑, Apoptosis↑, TumCP↓, EMT↓, Imm↑, ChemoSen↑, BioAv↓, TumCG↓, IL2↑, IL12↑, TNF-α↑, P-gp↓, MDR1↓, QoL↑, Casp↑, DNAdam↑, Bcl-2↓, BAX↑, MMP↓, Cyt‑c↑, NOTCH1↓, GSK‐3β↓, TumCCA↑, GSH↓, ROS↑, lipid-P↑, c-Iron↑, GPx4↓, ACSL4↑, Ferroptosis↑, Wnt↓, β-catenin/ZEB1↓, cycD1/CCND1↓, Akt↓, PI3K↓, mTOR↓, CXCR4↓, Vim↓, PD-L1↓, eff↑, eff↑, ChemoSen↑, ChemoSen↑, chemoP↑,
5441- AG,  Chemo,    Astragalus-containing Chinese herbal combinations for advanced non-small-cell lung cancer: a meta-analysis of 65 clinical trials enrolling 4751 patients
- Review, Lung, NA
eff↑, ChemoSen↑,
5440- AG,    Astragalus Injection Enhances the Sensitivity of Clinical Cancer Patients to Chemotherapy: A Systematic meta-Analysis
- Review, Var, NA
ChemoSen↑, OS↑,
5976- AgNPs,    Review on Harnessing Silver Nanoparticles for Therapeutic Innovations: A Comprehensive Review on Medical Applications, Safety, and Future Directions
- Review, Vit, NA
*Bacteria↓, AntiCan↑, *Inflam↓, *Wound Healing↑, eff↑, ChemoSen↑, EGFR↓, ROS↑, P53↑, BAX↑, Casp3↑, toxicity↝,
4406- AgNPs,    Silver nanoparticles achieve cytotoxicity against breast cancer by regulating long-chain noncoding RNA XLOC_006390-mediated pathway
- in-vitro, BC, MCF-7 - in-vitro, BC, T47D - in-vitro, BC, MDA-MB-231
TumCD↑, other↓, P53↑, TumCCA↑, Apoptosis↑, ChemoSen↑, tumCV↓, γH2AX↑, SOX4↓,
4431- AgNPs,  doxoR,    Oxidative Stress-Induced Silver Nano-Carriers for Chemotherapy
- in-vitro, BC, 4T1 - in-vivo, BC, 4T1 - in-vitro, Nor, 3T3
AntiCan↑, ROS↑, TumVol↓, EPR↑, selectivity↑, ChemoSen↑,
4564- AgNPs,  GoldNP,  Cu,  Chemo,  PDT  Cytotoxicity and targeted drug delivery of green synthesized metallic nanoparticles against oral Cancer: A review
- Review, Var, NA
ROS↑, DNAdam↑, TumCCA↑, eff↑, Apoptosis↑, eff↓, ChemoSen↑,
5142- AgNPs,    Biosynthesized Protein-Capped Silver Nanoparticles Induce ROS-Dependent Proapoptotic Signals and Prosurvival Autophagy in Cancer Cells
- in-vitro, CRC, HUH7
ROS↑, Apoptosis↑, eff↑, ChemoSen↑, EPR↑, Casp↑, MAPK↑,
5356- AL,    Therapeutic role of allicin in gastrointestinal cancers: mechanisms and safety aspects
- Review, GC, NA
Apoptosis↑, TumCP↓, MAPK↓, PI3K↓, Akt↓, NF-kB↓, AntiCan↑, ChemoSen↑, TumCCA↑, Apoptosis↑, BioAv↑, selectivity↑, TGF-β↓, ROS↑, DNAdam↑, p‑P53↑, P21↑, cycD1/CCND1↓, cycE/CCNE↓, CDK4↓, CDK6↓, MMP↓, NF-kB↑, BAX↑, Bcl-2↓, ER Stress↑, Casp↑, AIF↑, Fas↑, Casp8↑, Cyt‑c↑, cl‑PARP↑, Ca+2↑, *NRF2↑, *chemoP↑, *GutMicro↑, CycB/CCNB1↑, H2S↑, HIF-1↓, RadioS↑,
5355- AL,    Mini-review: The health benefits and applications of allicin
- Review, Var, NA
*BioAv↑, *cardioP↑, *hepatoP↑, *RenoP↑, *Half-Life↝, *BioAv↓, *neuroP↑, *cognitive↑, *ROS↓, *lipid-P↓, *DNArepair↑, *ChemoSen↑,
2646- AL,    Anti-Cancer Potential of Homemade Fresh Garlic Extract Is Related to Increased Endoplasmic Reticulum Stress
- in-vitro, Pca, DU145 - in-vitro, Melanoma, RPMI-8226
AntiCan↑, eff↓, ChemoSen↑, ER Stress↑, tumCV↓, DNAdam↑, GSH∅, HSP70/HSPA5↓, UPR↑, β-catenin/ZEB1↓, ROS↑, HO-2↑, SIRT1↑, GlucoseCon∅, lactateProd∅, chemoP↑,
2663- AL,    Therapeutic Effect of Allicin on Glioblastoma
- in-vitro, GBM, U251 - in-vitro, GBM, U87MG
BioAv↝, TumCCA↑, P53↑, HDAC↓, CSCs↓, ROS↑, ChemoSen↑, MGMT↓,
2667- AL,    Allicin in Digestive System Cancer: From Biological Effects to Clinical Treatment
- Review, GC, NA
AntiCan↑, ChemoSen↑, angioG↓, chemoP↑, *GutMicro↑, *antiOx↑, other↝, GSH↓, Thiols↓, *ROS↓, *hepatoP↑, *Inflam↓, *NF-kB↓,
3434- ALA,    Alpha lipoic acid modulates metabolic reprogramming in breast cancer stem cells enriched 3D spheroids by targeting phosphoinositide 3-kinase: In silico and in vitro insights
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
tumCV↓, PI3K↓, p‑Akt↓, p‑P70S6K↓, mTOR↓, ATP↓, GlucoseCon↓, ROS↑, PKM2↓, LDHA↓, Glycolysis↓, ChemoSen↑,
3436- ALA,    Alpha lipoic acid modulates metabolic reprogramming in breast cancer stem cells enriched 3D spheroids by targeting phosphoinositide 3-kinase: In silico and in vitro insights Author links open overlay panel
- in-vitro, BC, MCF-7
ChemoSen↑, PI3K↓, Akt↓, ATP↓, GlucoseCon↓, ROS↑, PKM2↓, Glycolysis↓, CSCs↓, IGF-1R↓, Furin↓, RadioS↑,
3541- ALA,    Insights on alpha lipoic and dihydrolipoic acids as promising scavengers of oxidative stress and possible chelators in mercury toxicology
- Review, Var, NA
*antiOx↑, *IronCh↑, *GSH↑, *BBB↑, Apoptosis↑, MMP↓, ROS↑, lipid-P↑, PARP1↑, Casp3↑, Casp9↑, *NRF2↑, *GSH↑, *ROS↓, RenoP↑, ChemoSen↑, *BG↓,
278- ALA,    The Multifaceted Role of Alpha-Lipoic Acid in Cancer Prevention, Occurrence, and Treatment
- Review, NA, NA
ROS↑, NRF2↑, Inflam↓, frataxin↑, *BioAv↓, ChemoSen↑, Hif1a↓, eff↑, FAK↓, ITGB1↓, MMP2↓, MMP9↓, EMT↓, Snail↓, Vim↓, Zeb1↓, P53↑, MGMT↓, Mcl-1↓, Bcl-xL↓, Bcl-2↓, survivin↓, Casp3↑, Casp9↑, BAX↑, p‑Akt↓, GSK‐3β↓, *antiOx↑, *ROS↓, selectivity↑, angioG↓, MMPs↓, NF-kB↓, ITGB3↓, NADPH↓,
1440- AMQ,    Lysosomotropism depends on glucose: a chloroquine resistance mechanism
- in-vitro, BC, 4T1
eff↑, Apoptosis↓, Necroptosis↑, eff↓, ChemoSen↑, eff↓,
1009- And,  5-FU,    Andrographis-mediated chemosensitization through activation of ferroptosis and suppression of β-catenin/Wnt-signaling pathways in colorectal cancer
- in-vivo, CRC, HCT116 - in-vitro, CRC, SW480
ChemoSen↑, Casp9↑, Ferroptosis↑, Wnt/(β-catenin)↓, FTL↑, TP53↑, ACSL5↑, GCLC↑, GCLM↑, SAT1↑, STEAP3↑, ACSL5↑,
1353- And,    Andrographolide Induces Apoptosis and Cell Cycle Arrest through Inhibition of Aberrant Hedgehog Signaling Pathway in Colon Cancer Cells
- in-vitro, Colon, HCT116
ChemoSen↑, TumCCA↑, CDK1↓, CycB/CCNB1↓, HH↓, Smo↓, Gli1↓,
1350- And,  Cisplatin,    Synergistic antitumor effect of Andrographolide and cisplatin through ROS-mediated ER stress and STAT3 inhibition in colon cancer
- in-vitro, Colon, NA
ChemoSen↑, ER Stress↑, STAT3↓, ROS↑,
4765- antiOx,  Chemo,    Antioxidants as precision weapons in war against cancer chemotherapy induced toxicity – Exploring the armoury of obscurity
- Review, Var, NA
chemoP↑, ChemoSen↑, OS↑, Dose↑, Risk↓, eff↓,
1549- Api,  Chemo,    Chemoprotective and chemosensitizing effects of apigenin on cancer therapy
- Review, NA, NA
ChemoSideEff↓, *toxicity∅, ChemoSen↑, eff↑, eff↑, eff↑,
1537- Api,    Apigenin as Tumor Suppressor in Cancers: Biotherapeutic Activity, Nanodelivery, and Mechanisms With Emphasis on Pancreatic Cancer
- Review, PC, NA
TumCP↓, TumCCA↑, Apoptosis↑, MMPs↓, Akt↓, *BioAv↑, *BioAv↓, Half-Life∅, Hif1a↓, GLUT1↓, VEGF↓, ChemoSen↑, ROS↑, Bcl-2↓, Bcl-xL↓, BAX↑, BIM↑,
2636- Api,    Apigenin unveiled: an encyclopedic review of its preclinical and clinical insights
- Review, NA, NA
*AntiCan↑, *cardioP↑, *neuroP↑, *Inflam↓, *antiOx↑, *hepatoP↑, ChemoSen↑,
2639- Api,    Plant flavone apigenin: An emerging anticancer agent
- Review, Var, NA
*antiOx↑, *Inflam↓, AntiCan↑, ChemoSen↑, BioEnh↑, chemoPv↑, IL6↓, STAT3↓, NF-kB↓, IL8↓, eff↝, Akt↓, PI3K↓, HER2/EBBR2↓, cycD1/CCND1↓, CycD3↓, p27↑, FOXO3↑, STAT3↓, MMP2↓, MMP9↓, VEGF↓, Twist↓, MMP↓, ROS↑, NADPH↑, NRF2↓, SOD↓, COX2↓, p38↑, Telomerase↓, HDAC↓, HDAC1↓, HDAC3↓, Hif1a↓, angioG↓, uPA↓, Ca+2↑, Bax:Bcl2↑, Cyt‑c↑, Casp9↑, Casp12↑, Casp3↑, cl‑PARP↑, E-cadherin↑, β-catenin/ZEB1↓, cMyc↓, CDK4↓, CDK2↓, CDK6↓, IGF-1↓, CK2↓, CSCs↓, FAK↓, Gli↓, GLUT1↓,
2640- Api,    Apigenin: A Promising Molecule for Cancer Prevention
- Review, Var, NA
chemoPv↑, ITGB4↓, TumCI↓, TumMeta↓, Akt↓, ERK↓, p‑JNK↓, *Inflam↓, *PKCδ↓, *MAPK↓, EGFR↓, CK2↓, TumCCA↑, CDK1↓, P53↓, P21↑, Bax:Bcl2↑, Cyt‑c↑, APAF1↑, Casp↑, cl‑PARP↑, VEGF↓, Hif1a↓, IGF-1↓, IGFBP3↑, E-cadherin↑, β-catenin/ZEB1↓, HSPs↓, Telomerase↓, FASN↓, MMPs↓, HER2/EBBR2↓, CK2↓, eff↑, AntiAg↑, eff↑, FAK↓, ROS↑, Bcl-2↓, Cyt‑c↑, cl‑Casp3↑, cl‑Casp7↑, cl‑Casp8↑, cl‑Casp9↑, cl‑IAP2↑, AR↓, PSA↓, p‑pRB↓, p‑GSK‐3β↓, CDK4↓, ChemoSen↑, Ca+2↑, cal2↑,
2594- Api,  docx,    Targeted hyaluronic acid-based lipid nanoparticle for apigenin delivery to induce Nrf2-dependent apoptosis in lung cancer cells
- in-vitro, Lung, A549
NRF2↓, ChemoSen↑,
2596- Api,  LT,    Natural Nrf2 Inhibitors: A Review of Their Potential for Cancer Treatment
- Review, Var, NA
NRF2↓, chemoPv↑, ChemoSen↑,
2584- Api,  Chemo,    The versatility of apigenin: Especially as a chemopreventive agent for cancer
- Review, Var, NA
ChemoSen↑, RadioS↑, eff↝, DR5↑, selectivity↑, angioG↓, selectivity↑, chemoP↑, MAPK↓, PI3K↓, Akt↓, mTOR↓, Wnt↓, β-catenin/ZEB1↓, GLUT1↓, radioP↑, BioAv↓, chemoPv↑,
2586- Api,  doxoR,    Apigenin sensitizes doxorubicin-resistant hepatocellular carcinoma BEL-7402/ADM cells to doxorubicin via inhibiting PI3K/Akt/Nrf2 pathway
- in-vitro, HCC, Bel-7402
NRF2↓, ChemoSen↑,
581- Api,  Cisplatin,    The natural flavonoid apigenin sensitizes human CD44+ prostate cancer stem cells to cisplatin therapy
- in-vitro, Pca, CD44+
Bcl-2↓, survivin↓, Casp8↑, P53↑, Sharpin↓, APAF1↑, p‑Akt↓, NF-kB↓, P21↑, Cyc↓, CDK2↓, CDK4/6↓, Snail↓, ChemoSen↑,
3382- ART/DHA,    Repurposing Artemisinin and its Derivatives as Anticancer Drugs: A Chance or Challenge?
- Review, Var, NA
AntiCan↑, toxicity↑, Ferroptosis↑, ROS↑, TumCCA↑, BioAv↝, eff↝, Half-Life↓, Ferritin↓, GPx4↓, NADPH↓, GSH↓, BAX↑, Cyt‑c↑, cl‑Casp3↑, VEGF↓, IL8↓, COX2↓, MMP9↓, E-cadherin↑, MMP2↓, NF-kB↓, p16↑, CDK4↓, cycD1/CCND1↓, p62↓, LC3II↑, EMT↓, CSCs↓, Wnt↓, β-catenin/ZEB1↓, uPA↓, TumAuto↑, angioG↓, ChemoSen↑,
3396- ART/DHA,    Progress on the study of the anticancer effects of artesunate
- Review, Var, NA
TumCP↓, TumCI↓, TumCMig↓, Apoptosis↑, Diff↑, TumAuto↑, angioG↓, TumCCA↑, ROS↑, AMPK↑, mTOR↑, ChemoSen↑, Tf↑, Ferroptosis↑, Ferritin↓, lipid-P↑, CDK1↑, CDK2↑, CDK4↑, CDK6↑, SIRT1↑, COX2↓, IL1β↓, survivin↓, DNAdam↑, RadioS↑,
5380- ART/DHA,    Artemisinin and Its Derivatives as Potential Anticancer Agents
- Review, Var, NA
TumCG↓, angioG↓, Ferroptosis↑, TumCP↑, TumAuto↑, CSCs↑, eff↑, YAP/TEAD↓, TumCCA↑, ROS↑, ChemoSen↑, N-cadherin↓, Vim↓, MMP9↓, eff↑, STAT3↓, CD133↓, CD44↓, Nanog↓, cMyc↓, OCT4↓, Akt↓, mTOR↓,
5379- ART/DHA,    Iron-fueled ferroptosis: a new axis for immunomodulation to overcome cancer drug resistance—from immune microenvironment crosstalk to therapeutic translation
Ferritin↓, Iron↑, Fenton↑, lipid-P↑, ChemoSen↑, ROS↑, eff↝,
5378- ART/DHA,    Natural Agents Modulating Ferroptosis in Cancer: Molecular Pathways and Therapeutic Perspectives
- Review, Var, NA
Ferroptosis↑, Iron↑, lipid-P↑, MOMP↑, AntiCan↑, NCOA4↑, GSH↓, GPx4↓, ROS↑, ChemoSen↑, ER Stress↑, DNAdam↑, angioG↓, TumCCA↑, eff↓,

Showing Research Papers: 1 to 50 of 507
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 507

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Fenton↑, 1,   Ferroptosis↑, 6,   frataxin↑, 1,   GCLC↑, 1,   GCLM↑, 1,   GPx4↓, 4,   GSH↓, 8,   GSH∅, 1,   HO-2↑, 1,   Iron↑, 2,   c-Iron↑, 1,   lipid-P↑, 5,   NRF2↓, 4,   NRF2↑, 1,   mt-OXPHOS↓, 2,   ROS↑, 28,   SOD↓, 1,   Thiols↓, 1,   TrxR↓, 3,   xCT↓, 1,  

Metal & Cofactor Biology ⓘ

Ferritin↓, 3,   FTL↑, 1,   NCOA4↑, 1,   STEAP3↑, 1,   Tf↑, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   ATP↓, 4,   mitResp↓, 1,   MMP↓, 6,   mtDam↑, 1,  

Core Metabolism/Glycolysis ⓘ

ACSL4↑, 1,   ACSL5↑, 2,   AMPK↑, 2,   cMyc↓, 3,   FASN↓, 1,   GAPDH↓, 2,   GlucoseCon↓, 3,   GlucoseCon∅, 1,   GlutaM↓, 1,   Glycolysis↓, 5,   H2S↑, 1,   HK2↓, 3,   lactateProd∅, 1,   LDH↓, 1,   LDHA↓, 2,   NADPH↓, 2,   NADPH↑, 1,   PDH↓, 1,   PKM2↓, 3,   SAT1↑, 1,   SIRT1↓, 1,   SIRT1↑, 2,   SREBP1↓, 1,   TCA↓, 1,  

Cell Death ⓘ

Akt↓, 9,   p‑Akt↓, 3,   APAF1↑, 2,   Apoptosis↓, 1,   Apoptosis↑, 13,   BAX↑, 7,   Bax:Bcl2↑, 2,   Bcl-2↓, 9,   Bcl-xL↓, 3,   BIM↑, 1,   Casp↑, 4,   Casp12↑, 1,   Casp3↓, 1,   Casp3↑, 7,   cl‑Casp3↑, 2,   Casp7↑, 1,   cl‑Casp7↑, 1,   Casp8↑, 2,   cl‑Casp8↑, 1,   Casp9↑, 5,   cl‑Casp9↑, 1,   CK2↓, 3,   Cyt‑c↑, 8,   DR5↑, 1,   Fas↑, 2,   Ferroptosis↑, 6,   cl‑IAP2↑, 1,   JNK↓, 1,   p‑JNK↓, 1,   MAPK↓, 2,   MAPK↑, 1,   Mcl-1↓, 3,   MOMP↑, 1,   Necroptosis↑, 1,   p27↑, 1,   p38↑, 1,   survivin↓, 3,   Telomerase↓, 2,   TumCD↑, 2,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction ⓘ

HER2/EBBR2↓, 2,  

Transcription & Epigenetics ⓘ

other↓, 2,   other↝, 1,   p‑pRB↓, 1,   tumCV↓, 3,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 6,   HSP70/HSPA5↓, 1,   HSPs↓, 1,   UPR↑, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↑, 1,   p62↓, 2,   TumAuto↑, 5,   mt-TumAuto↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 7,   MGMT↓, 2,   p16↑, 1,   P53↓, 1,   P53↑, 6,   p‑P53↑, 1,   PARP↓, 1,   cl‑PARP↑, 4,   PARP1↑, 1,   TP53↑, 1,   γH2AX↑, 2,  

Cell Cycle & Senescence ⓘ

CDK1↓, 2,   CDK1↑, 1,   CDK2↓, 2,   CDK2↑, 1,   CDK4↓, 4,   CDK4↑, 1,   Cyc↓, 1,   CycB/CCNB1↓, 1,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 6,   CycD3↓, 1,   cycE/CCNE↓, 1,   P21↑, 4,   TumCCA↑, 13,  

Proliferation, Differentiation & Cell State ⓘ

CD133↓, 2,   CD44↓, 2,   CSCs↓, 5,   CSCs↑, 1,   Diff↑, 2,   EMT↓, 4,   ERK↓, 1,   FOXO3↑, 1,   Gli↓, 1,   Gli1↓, 1,   GSK‐3β↓, 2,   p‑GSK‐3β↓, 1,   HDAC↓, 3,   HDAC1↓, 1,   HDAC3↓, 1,   HH↓, 1,   IGF-1↓, 2,   IGF-1R↓, 1,   IGFBP3↑, 1,   mTOR↓, 6,   mTOR↑, 1,   Nanog↓, 1,   NOTCH1↓, 2,   NOTCH3↓, 1,   OCT4↓, 1,   p‑P70S6K↓, 1,   PI3K↓, 7,   Smo↓, 1,   STAT3↓, 4,   TumCG↓, 4,   Wnt↓, 5,   Wnt/(β-catenin)↓, 1,  

Migration ⓘ

AntiAg↑, 1,   Ca+2↑, 3,   cal2↑, 1,   CDK4/6↓, 1,   CEA↓, 1,   E-cadherin↑, 3,   FAK↓, 3,   Furin↓, 1,   ITGB1↓, 1,   ITGB3↓, 1,   ITGB4↓, 1,   miR-133a-3p↑, 1,   MMP2↓, 3,   MMP9↓, 6,   MMPs↓, 3,   N-cadherin↓, 1,   Sharpin↓, 1,   Snail↓, 2,   SOX4↓, 1,   TGF-β↓, 1,   TumCA↑, 1,   TumCI↓, 3,   TumCMig↓, 1,   TumCP↓, 7,   TumCP↑, 1,   TumMeta↓, 2,   Twist↓, 1,   uPA↓, 2,   Vim↓, 4,   Zeb1↓, 1,   β-catenin/ZEB1↓, 8,  

Angiogenesis & Vasculature ⓘ

angioG↓, 10,   EGFR↓, 3,   EPR↑, 2,   HIF-1↓, 1,   Hif1a↓, 4,   VEGF↓, 5,  

Barriers & Transport ⓘ

GLUT1↓, 3,   P-gp↓, 2,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 3,   CXCR4↓, 1,   IL12↑, 1,   IL1β↓, 1,   IL2↑, 1,   IL6↓, 1,   IL8↓, 2,   Imm↑, 3,   Inflam↓, 1,   NF-kB↓, 7,   NF-kB↑, 1,   p50↓, 1,   PD-L1↓, 1,   PSA↓, 1,   TNF-α↑, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,   CDK6↓, 2,   CDK6↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioAv↑, 1,   BioAv↝, 2,   BioEnh↑, 1,   ChemoSen↑, 52,   Dose↑, 1,   Dose↝, 2,   eff↓, 7,   eff↑, 21,   eff↝, 4,   Half-Life↓, 1,   Half-Life∅, 1,   MDR1↓, 1,   RadioS↑, 6,   selectivity↑, 7,  

Clinical Biomarkers ⓘ

AR↓, 1,   CEA↓, 1,   EGFR↓, 3,   Ferritin↓, 3,   HER2/EBBR2↓, 2,   IL6↓, 1,   LDH↓, 1,   PD-L1↓, 1,   PSA↓, 1,   TP53↑, 1,  

Functional Outcomes ⓘ

AntiCan↑, 9,   AntiTum↑, 2,   chemoP↑, 6,   chemoPv↑, 4,   ChemoSideEff↓, 1,   hepatoP∅, 1,   OS↑, 2,   QoL↑, 4,   radioP↑, 1,   RenoP↑, 1,   RenoP∅, 1,   Risk↓, 1,   toxicity↓, 1,   toxicity↑, 1,   toxicity↝, 2,   TumVol↓, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 1,  
Total Targets: 265

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 5,   GSH↑, 2,   lipid-P↓, 1,   NRF2↑, 2,   ROS↓, 4,  

Metal & Cofactor Biology ⓘ

IronCh↑, 1,  

Cell Death ⓘ

MAPK↓, 1,  

DNA Damage & Repair ⓘ

DNArepair↑, 1,  

Migration ⓘ

PKCδ↓, 1,  

Barriers & Transport ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 5,   NF-kB↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 3,   BioAv↑, 2,   ChemoSen↑, 1,   Half-Life↝, 1,  

Clinical Biomarkers ⓘ

BG↓, 1,   GutMicro↑, 2,  

Functional Outcomes ⓘ

AntiCan↑, 1,   cardioP↑, 2,   chemoP↑, 1,   cognitive↑, 1,   hepatoP↑, 3,   neuroP↑, 2,   RenoP↑, 1,   toxicity∅, 1,   Wound Healing↑, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 1,  
Total Targets: 28

Scientific Paper Hit Count for: ChemoSen, chemo-sensitization
28 Chemotherapy
26 Cisplatin
19 Curcumin
15 doxorubicin
15 Resveratrol
14 Thymoquinone
13 Artemisinin
13 Baicalein
13 Betulinic acid
13 Sulforaphane (mainly Broccoli)
12 Quercetin
11 Capsaicin
11 Magnetic Fields
10 Apigenin (mainly Parsley)
10 diet FMD Fasting Mimicking Diet
10 Fisetin
9 Propolis -bee glue
9 Lycopene
8 Docetaxel
8 Luteolin
8 brusatol
8 Boswellia (frankincense)
8 Selenium NanoParticles
8 Chrysin
8 salinomycin
8 Vitamin C (Ascorbic Acid)
8 Shikonin
7 Astragalus
7 Copper and Cu NanoParticles
7 Ashwagandha(Withaferin A)
7 diet Methionine-Restricted Diet
7 Gambogic Acid
7 Pterostilbene
7 Selenite (Sodium)
6 5-fluorouracil
6 Gemcitabine (Gemzar)
6 Berberine
6 borneol
6 chitosan
6 Disulfiram
6 Honokiol
6 Metformin
6 Phenethyl isothiocyanate
6 Rosmarinic acid
6 Vitamin K2
5 Sorafenib (brand name Nexavar)
5 Radiotherapy/Radiation
5 Silver-NanoParticles
5 Allicin (mainly Garlic)
5 Atorvastatin
5 diet Short Term Fasting
5 EGCG (Epigallocatechin Gallate)
5 Melatonin
5 Piperlongumine
5 VitK3,menadione
4 2-DeoxyGlucose
4 Alpha-Lipoic-Acid
4 Astaxanthin
4 Caffeic acid
4 Chlorogenic acid
4 Citric Acid
4 Oxygen, Hyperbaric
4 Ellagic acid
4 Paclitaxel
4 Magnolol
3 Auranofin
3 Andrographis
3 beta-glucans
3 Baicalin
3 Berbamine
3 Brucea javanica
3 Piperine
3 Caffeic Acid Phenethyl Ester (CAPE)
3 Carvacrol
3 Celastrol
3 Emodin
3 Electrical Pulses
3 Bicarbonate(Sodium)
3 Phenylbutyrate
3 Selenium
3 Silymarin (Milk Thistle) silibinin
3 Urolithin
2 3-bromopyruvate
2 immunotherapy
2 Biochanin A
2 Bromelain
2 Boron
2 erastin
2 Carnosic acid
2 Thymol-Thymus vulgaris
2 Cat’s Claw
2 Cannabidiol
2 chemodynamic therapy
2 Celecoxib
2 Folic Acid, Vit B9
2 Chlorophyllin
2 Coenzyme Q10
2 Calorie Restriction Mimetics
2 Dichloroacetate
2 Exercise
2 Shilajit/Fulvic Acid
2 Hydrogen Gas
2 Spermidine
2 Hydroxycinnamic-acid
2 Naringin
2 Niclosamide (Niclocide)
2 Hyperthermia
2 Plumbagin
2 Psoralidin
2 Oxaliplatin
1 Gold NanoParticles
1 Photodynamic Therapy
1 Amodiaquine
1 Anti-oxidants
1 temozolomide
1 Aspirin -acetylsalicylic acid
1 Dipyridamole
1 Aloe anthraquinones
1 epirubicin
1 Lapatinib
1 Ras-selective lethal 3
1 Butyrate
1 Trastuzumab
1 urea
1 Vitamin E
1 diet Ketogenic
1 Zinc
1 Ferulic acid
1 Garcinol
1 γ-linolenic acid (Borage Oil)
1 HydroxyCitric Acid
1 HydroxyTyrosol
1 Bortezomib
1 carboplatin
1 Moringa oleifera
1 Mushroom Reishi
1 nelfinavir/Viracept
1 Proanthocyanidins
1 SonoDynamic Therapy UltraSound
1 Propyl gallate
1 Ramucirumab (CYRAMZA)
1 Rutin
1 Sulfasalazine
1 irinotecan
1 Aflavin-3,3′-digallate
1 Vitamin D3
1 Zerumbone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1106  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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