RadioS Cancer Research Results

RadioS, RadioSensitizer: Click to Expand ⟱
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Type:
A radiosensitizer is an agent that makes cancer cells more sensitive to the damaging effects of radiation therapy. By using a radiosensitizer, clinicians aim to enhance the effectiveness of radiation treatment by either increasing the damage incurred by tumor cells or by interfering with the cancer cells’ repair mechanisms. This can potentially allow for lower doses of radiation, reduced side effects, or improved treatment outcomes.
Pathways that help Radiosensitivity: downregulating HIF-1α, increase SIRT1, Txr

List of Natural Products with radiosensitizing properties:
-Curcumin:modulate NF-κB, STAT3 and has been shown in preclinical studies to enhance the effects of radiation by inhibiting cell survival pathways.
-Resveratrol:
-EGCG:
-Quercetin:
-Genistein:
-Parthenolide:

How radiosensitizers inhibit the thioredoxin (Trx) system in cellular contexts. Notable radiosensitizers, including:
-gold nanoparticles (GNPs),
-gold triethylphosphine cyanide ([Au(SCN) (PEt3)]),
-auranofin, ceria nanoparticles (CONPs),
-curcumin and its derivatives,
-piperlongamide,
-indolequinone derivatives,
-micheliolide,
-motexafin gadolinium, and
-ethane selenide selenidazole derivatives (SeDs)
Scientific Papers found: Click to Expand⟱
4384- ,    Silver nanoparticles: synthesis, properties, and therapeutic applications
- Review, Var, NA
AntiCan↑, RadioS↑, CellMemb↑, ROS↑, DNAdam↑, PhotoS↑, eff↑,
2327- 2DG,    2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents
- Review, Var, NA
Glycolysis↓, HK2↓, mt-ROS↑, AMPK↑, PPP↓, NADPH↓, GSH↓, Bax:Bcl2↑, Apoptosis↑, RadioS↑, eff↓, Half-Life↓, other↝, eff↓,
5282- 3BP,  Rad,    3-Bromopyruvate-mediated MCT1-dependent metabolic perturbation sensitizes triple negative breast cancer cells to ionizing radiation
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468
Glycolysis↓, RadioS↑, eff↑, GAPDH↓, PPP↑, GSH↓, ECAR↓,
5279- 3BP,  Rad,    Abstract 5243: 3-Bromopyruvate in combination with radiation inhibits pancreatic cancer growth by dismantling mitochondria and ATP generation in a preclinical mouse model
- in-vivo, PC, NA
ATP↓, HK2↓, RadioS↑,
5466- AF,    Auranofin Inhibition of Thioredoxin Reductase in a Preclinical Model of Small Cell Lung Cancer
- in-vivo, Lung, NA
TrxR↓, Dose↝, RadioS↑, ChemoSen↑, ROS↑, Diff↑, toxicity↓,
5460- AF,    Auranofin radiosensitizes tumor cells through targeting thioredoxin reductase and resulting overproduction of reactive oxygen species
- vitro+vivo, Var, 4T1
RadioS↑, ROS↑, eff↓, mt-OCR↓, DNAdam↑, Apoptosis↑, TrxR↓, eff↑,
5432- AG,    Astragalus polysaccharides combined with radiochemotherapy for cervical cancer: a systematic review and meta-analysis of randomized controlled studies
- Review, Cerv, NA
ChemoSen↑, eff↑, RadioS↑, CEA↓, Wnt↓, β-catenin/ZEB1↓, γH2AX↑, ER Stress↑, mt-TumAuto↑, QoL↑, Imm↑,
4401- AgNPs,  Rad,    Metformin-loaded chitosan nanoparticles augment silver nanoparticle-induced radiosensitization in breast cancer cells during radiation therapy
- in-vitro, BC, NA
RadioS↑, DNAdam↑,
4400- AgNPs,  Rad,    Differential cytotoxic and radiosensitizing effects of silver nanoparticles on triple-negative breast cancer and non-triple-negative breast cells
- in-vitro, BC, MCF-7 - in-vitro, Nor, MCF10 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549 - in-vivo, BC, MDA-MB-231
ROS↑, DNAdam↑, selectivity↑, TumCG↓, RadioS↑, Dose↝, selectivity↑, other↝, eff↓, eff↑, γH2AX↑, Dose↓, eff↑,
4362- AgNPs,    Enhancing Colorectal Cancer Radiation Therapy Efficacy using Silver Nanoprisms Decorated with Graphene as Radiosensitizers
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT29 - in-vivo, NA, NA
eff↑, TumCG↓, OS↑, RadioS↑, eff↑, ROS↑, DNAdam↑, eff↝,
4358- AgNPs,  HPT,  Rad,    Silver nanocrystals mediated combination therapy of radiation with magnetic hyperthermia on glioma cells
- in-vitro, GBM, U251
RadioS↑, eff↑, TumCD↑,
4436- AgNPs,    Silver Nanoparticles (AgNPs) as Enhancers of Everolimus and Radiotherapy Sensitivity on Clear Cell Renal Cell Carcinoma
- in-vitro, Kidney, 786-O
ROS↑, MMP↑, TumCCA↑, TumCP↓, Apoptosis↑, RadioS↑,
4378- AgNPs,    Exploring silver nanoparticles for cancer therapy and diagnosis
- Review, Var, NA
AntiTum↑, ROS↑, eff↑, RadioS↑,
4365- AgNPs,    Biomedical Applications of Silver Nanoparticles: An Up-to-Date Overview
- Review, Var, NA
ROS↑, *toxicity↓, *Bacteria↓, *Inf↓, *Diff↑, *eff↑, RadioS↑, selectivity↑,
4563- AgNPs,  Rad,    Silver nanoparticles enhance neutron radiation sensitivity in cancer cells: An in vitro study
- in-vitro, BC, MCF-7 - in-vitro, Ovarian, SKOV3 - in-vitro, GBM, U87MG - in-vitro, Melanoma, A431
RadioS↑, ROS↑, TumCCA↑, Apoptosis↑, ER Stress↑,
4583- AgNPs,    Metal-Based Nanoparticles for Cardiovascular Diseases
- Review, NA, NA
RadioS↑, *ROS↑, *BBB↝,
306- AgNPs,    Cancer Therapy by Silver Nanoparticles: Fiction or Reality?
- Analysis, NA, NA
EPR↝, ROS↑, IL1↑, IL8↑, ER Stress↑, MMP9↑, MMP↓, Cyt‑c↑, Apoptosis↑, Hif1a↑, BBB↑, GutMicro↝, eff↑, eff↑, RadioS↑,
5356- AL,    Therapeutic role of allicin in gastrointestinal cancers: mechanisms and safety aspects
- Review, GC, NA
Apoptosis↑, TumCP↓, MAPK↓, PI3K↓, Akt↓, NF-kB↓, AntiCan↑, ChemoSen↑, TumCCA↑, Apoptosis↑, BioAv↑, selectivity↑, TGF-β↓, ROS↑, DNAdam↑, p‑P53↑, P21↑, cycD1/CCND1↓, cycE/CCNE↓, CDK4↓, CDK6↓, MMP↓, NF-kB↑, BAX↑, Bcl-2↓, ER Stress↑, Casp↑, AIF↑, Fas↑, Casp8↑, Cyt‑c↑, cl‑PARP↑, Ca+2↑, *NRF2↑, *chemoP↑, *GutMicro↑, CycB/CCNB1↑, H2S↑, HIF-1↓, RadioS↑,
2668- AL,  Rad,    Allicin enhances the radiosensitivity of colorectal cancer cells via inhibition of NF-κB signaling pathway
- in-vitro, CRC, HCT116
RadioS↑, NF-kB↓,
3436- ALA,    Alpha lipoic acid modulates metabolic reprogramming in breast cancer stem cells enriched 3D spheroids by targeting phosphoinositide 3-kinase: In silico and in vitro insights Author links open overlay panel
- in-vitro, BC, MCF-7
ChemoSen↑, PI3K↓, Akt↓, ATP↓, GlucoseCon↓, ROS↑, PKM2↓, Glycolysis↓, CSCs↓, IGF-1R↓, Furin↓, RadioS↑,
4759- antiOx,  Chemo,    Potential Contributions of Antioxidants to Cancer Therapy: Immunomodulation and Radiosensitization
- Review, Var, NA
TumCD↑, TumCG↓, ROS⇅, eff↑, RadioS↑, TumCG↓, OS↑, toxicity∅, toxicity↑,
2583- Api,  Rad,    The influence of apigenin on cellular responses to radiation: From protection to sensitization
- Review, Var, NA
radioP↑, RadioS↑, *COX2↓, *ROS↓, VEGF↓, MMP2↓, STAT3↓, AMPK↑, Apoptosis↑, MMP9↓, glucose↓,
2584- Api,  Chemo,    The versatility of apigenin: Especially as a chemopreventive agent for cancer
- Review, Var, NA
ChemoSen↑, RadioS↑, eff↝, DR5↑, selectivity↑, angioG↓, selectivity↑, chemoP↑, MAPK↓, PI3K↓, Akt↓, mTOR↓, Wnt↓, β-catenin/ZEB1↓, GLUT1↓, radioP↑, BioAv↓, chemoPv↑,
2319- Api,    Apigenin sensitizes radiotherapy of mouse subcutaneous glioma through attenuations of cell stemness and DNA damage repair by inhibiting NF-κB/HIF-1α-mediated glycolysis
- in-vitro, GBM, NA
Glycolysis↓, NF-kB↓, p65↓, Hif1a↓, GLUT1↓, GLUT3↓, PKM2↓, RadioS↑, TumVol↓, TumW↓,
3396- ART/DHA,    Progress on the study of the anticancer effects of artesunate
- Review, Var, NA
TumCP↓, TumCI↓, TumCMig↓, Apoptosis↑, Diff↑, TumAuto↑, angioG↓, TumCCA↑, ROS↑, AMPK↑, mTOR↑, ChemoSen↑, Tf↑, Ferroptosis↑, Ferritin↓, lipid-P↑, CDK1↑, CDK2↑, CDK4↑, CDK6↑, SIRT1↑, COX2↓, IL1β↓, survivin↓, DNAdam↑, RadioS↑,
5415- ASA,    The Anti-Metastatic Role of Aspirin in Cancer: A Systematic Review
- Review, Var, NA
TumMeta↓, COX1↓, TXA2↓, AntiAg↑, EMT↓, TumCMig↓, TumCI↓, AMPK↑, cMyc↓, PGE2↓, Dose↑, RadioS↑, PD-L1↓, E-cadherin↑, EMT↓, Slug↓, Vim↓, Twist↓, MMP2↓, MMP9↓, other↑,
5396- Ash,    Withania Somnifera (Ashwagandha) and Withaferin A: Potential in Integrative Oncology
- Review, Var, NA
selectivity↑, ROS↑, Apoptosis↑, ChemoSen↑, RadioS↑, NF-kB↓, ER-α36↓, P53↑, *ROS∅, γH2AX↑, DNAdam↑, MMP↓, XIAP↓, IAP1↓, survivin↓, SOD↓, Dose↝, IL6↓, TNF-α↓, COX2↓, p‑Akt↓, NOTCH1↓, FOXO↑, Casp↑, MMP2↓, CSCs↓, *ROS↓, *SOD2↑, chemoP↑, ChemoSen↑, RadioS↑,
3166- Ash,    Exploring the Multifaceted Therapeutic Potential of Withaferin A and Its Derivatives
- Review, Var, NA
*p‑PPARγ↓, *cardioP↑, *AMPK↑, *BioAv↝, *Half-Life↝, *Half-Life↝, *Dose↑, *chemoPv↑, IL6↓, STAT3↓, ROS↓, OXPHOS↓, PCNA↓, LDH↓, AMPK↑, TumCCA↑, NOTCH3↓, Akt↓, Bcl-2↓, Casp3↑, Apoptosis↑, eff↑, NF-kB↓, CSCs↓, HSP90↓, PI3K↓, FOXO3↑, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, FASN↓, ACLY↓, ROS↑, NRF2↑, HO-1↑, NQO1↑, JNK↑, mTOR↓, neuroP↑, *TNF-α↓, *IL1β↓, *IL6↓, *IL8↓, *IL18↓, RadioS↑, eff↑,
2002- Ash,    Ancient medicine, modern use: Withania somnifera and its potential role in integrative oncology
- Review, Var, NA
antiOx↑, Inflam↓, TumCP↓, OS↑, RadioS↑, radioP↑, chemoP↑,
4823- ASTX,    Astaxanthin increases radiosensitivity in esophageal squamous cell carcinoma through inducing apoptosis and G2/M arrest
- in-vitro, ESCC, NA
RadioS↑, Apoptosis↑, TumCCA↑, Bcl-2↓, CycB/CCNB1↓, CDC2↓, BAX↑,
4822- ASTX,  Rad,    Astaxanthin Synergizes with Ionizing Radiation (IR) in Oral Squamous Cell Carcinoma (OSCC)
tumCV↓, selectivity↑, RadioS↑, GPx4↓, Ferroptosis↑,
5454- ATV,    Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility
- Review, BC, NA
HMG-CoA↓, HMGCR↓, TumCP↓, RadioS↑, CD44↓, P53↑,
5450- ATV,    The Mevalonate Pathway in the Radiation Response of Cancer
- vitro+vivo, Var, NA
eff↑, RadioS↑,
5448- ATV,    Beyond cardiovascular health: The pharmacotherapeutic potential of statins in oncology
- Review, Var, NA
Apoptosis↑, TumAuto↑, TumCCA↑, BioAv↓, eff↑, HMGCR↓, LDL↓, cardioP↑, AntiTum↑, ChemoSen↑, RadioS↑, toxicity↓,
4978- ATV,  Rad,    Atorvastatin Sensitizes Breast and Lung Cancer Cells to Ionizing Radiation
- in-vitro, BC, A549
Apoptosis↑, RadioS↑, TumCP↓, ROS↑,
5507- Ba,    Baicalein Enhances Radiosensitivity in Colorectal Cancer via JAK2/STAT3 Pathway Inhibition
- vitro+vivo, Var, NA
RadioS↑, p‑STAT3↓, JAK2↓, PD-L1↓, SOCS-3↑,
5249- Ba,  BA,    Baicalein and baicalin in cancer therapy: Multifaceted mechanisms, preclinical evidence, and translational challenges
- Review, Var, NA
Apoptosis↑, Inflam↓, TumCCA↑, ChemoSen↑, RadioS↑, TumCG↓, toxicity↓, BioAv↓, Half-Life↓,
5251- Ba,    The Fascinating Effects of Baicalein on Cancer: A Review
- Review, Var, NA
AntiTum↑, TumCCA↓, ROS↓, MAPK↓, Akt↓, mTOR↓, Casp3↑, Casp9↑, TumCI↓, TumMeta↓, MMP2↓, MMP9↓, Securin↓, γH2AX↝, N-cadherin↓, Vim↓, Zeb1↓, ZEB2↓, TumCMig↓, TumCG↑, 12LOX↓, DR5↑, ROS↑, RadioS↑, ChemoSen↑, BioAv↓,
2481- Ba,  Rad,    Radiotherapy Increases 12-LOX and CCL5 Levels in Esophageal Cancer Cells and Promotes Cancer Metastasis via THP-1-Derived Macrophages
- in-vitro, ESCC, Eca109 - in-vitro, ESCC, KYSE150
12LOX↓, RadioS↑, Dose↝, RANTES↓, MCP1↓,
2622- Ba,  Cisplatin,  Rad,    Natural Baicalein-Rich Fraction as Radiosensitizer in Combination with Bismuth Oxide Nanoparticles and Cisplatin for Clinical Radiotherapy
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF-7
RadioS↑,
2297- Ba,    Significance of flavonoids targeting PI3K/Akt/HIF-1α signaling pathway in therapy-resistant cancer cells – A potential contribution to the predictive, preventive, and personalized medicine
- Review, Var, NA
Glycolysis↓, Hif1a↓, PKM2↓, RadioS↑,
2391- Ba,    Scutellaria baicalensis and its flavonoids in the treatment of digestive system tumors
- Review, GC, NA
Hif1a↓, PKM2↓, RadioS↑, Glycolysis↓, PAK↓,
5536- BBM,    Regulation of Cell-Signaling Pathways by Berbamine in Different Cancers
- Review, Var, NA
JAK↝, STAT3↓, p‑CaMKII ↓, TGF-β↑, Smad1↑, ChemoSen↑, RadioS↑, TumCI↓, TumCMig↓, ROS↑, NRF2↓, SOD2↓, GPx1↓, HO-1↓,
2021- BBR,    Berberine: An Important Emphasis on Its Anticancer Effects through Modulation of Various Cell Signaling Pathways
- Review, NA, NA
*antiOx?, *Inflam↓, Apoptosis↑, TumCCA↑, BAX↑, eff↑, VEGF↓, PI3K↓, Akt↓, mTOR↓, Telomerase↓, β-catenin/ZEB1↓, Wnt↓, EGFR↓, AP-1↓, NF-kB↓, COX2↑, NRF2↓, RadioS↑, STAT3↓, ERK↓, AR↓, ROS↑, eff↑, selectivity↑, selectivity↑, BioAv↓, DNMT1↓, cMyc↓,
1390- BBR,  Rad,    Berberine Inhibited Radioresistant Effects and Enhanced Anti-Tumor Effects in the Irradiated-Human Prostate Cancer Cells
- in-vitro, Pca, PC3
RadioS↑, Apoptosis↑, ROS↑, eff↑, BAX↑, Casp3↑, P53↑, p38↑, JNK↑, Bcl-2↓, ERK↓, HO-1↓,
1381- BBR,  Rad,    Berberine enhances the sensitivity of radiotherapy in ovarian cancer cell line (SKOV-3)
- in-vitro, Ovarian, SKOV3
RadioS↑, ROS↑, GSH↓, Apoptosis↑,
1399- BBR,  Rad,    Radiotherapy Enhancing and Radioprotective Properties of Berberine: A Systematic Review
- Review, NA, NA
*ROS↓, *MDA↓, *TNF-α↓, *TGF-β↓, *IL10↑, ROS↑, DNAdam↑, mtDam↑, MMP↓, Apoptosis↑, TumCCA↑, Hif1a↓, VEGF↓, RadioS↑,
2715- BBR,  Rad,    Berberine Can Amplify Cytotoxic Effect of Radiotherapy by Targeting Cancer Stem Cells
- in-vitro, BC, MCF-7
tumCV↓, OCT4↓, SOX2↓, RadioS↑, CSCs↓,
2686- BBR,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, Nor, NA
Inflam↓, IL6↓, MCP1↓, COX2↓, PGE2↓, MMP2↓, MMP9↓, DNAdam↑, eff↝, Telomerase↓, Bcl-2↓, AMPK↑, ROS↑, MMP↓, ATP↓, p‑mTORC1↓, p‑S6K↓, ERK↓, PI3K↓, PTEN↑, Akt↓, Raf↓, MEK↓, Dose↓, Dose↑, selectivity↑, TumCCA↑, eff↑, EGFR↓, Glycolysis↓, Dose?, p27↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycE/CCNE↓, Bax:Bcl2↑, Casp3↑, Casp9↑, VEGFR2↓, ChemoSen↑, eff↑, eff↑, PGE2↓, JAK2↓, STAT3↓, CXCR4↓, CCR7↓, uPA↓, CSCs↓, EMT↓, Diff↓, CD133↓, Nestin↓, n-MYC↓, NOTCH↓, SOX2↓, Hif1a↓, VEGF↓, RadioS↑,
5633- BCA,    Mechanisms Behind the Pharmacological Application of Biochanin-A: A review
- Review, Var, NA - Review, AD, NA
*AntiDiabetic↑, *neuroP↑, *toxicity↓, *CYP19↓, p‑Akt↓, mTOR↓, TumCCA↑, P21↑, Casp3↑, Bcl-2↑, Apoptosis↑, E-cadherin↓, TumMeta↓, eff↑, GSK‐3β↓, β-catenin/ZEB1↓, RadioS↑, ROS↑, Casp1↑, MMP2↓, MMP9↓, EGFR↓, ChemoSen↑, PI3K↓, MMPs↓, Hif1a↓, VEGF↓, *ROS↓, *Obesity↓, *cardioP↑, *NRF2↑, *NF-kB↓, *Inflam↓, *lipid-P↓, *hepatoP↑, *AST↓, *ALP↓, *Bacteria↓, *neuroP↑, *SOD↑, *GPx↑, *AChE↓, *BACE↓, *memory↑, *BioAv↓,

Showing Research Papers: 1 to 50 of 210
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 210

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Ferroptosis↑, 2,   GPx1↓, 1,   GPx4↓, 1,   GSH↓, 3,   HO-1↓, 2,   HO-1↑, 1,   lipid-P↑, 1,   NQO1↑, 1,   NRF2↓, 2,   NRF2↑, 1,   OXPHOS↓, 1,   ROS↓, 2,   ROS↑, 24,   ROS⇅, 1,   mt-ROS↑, 1,   SOD↓, 1,   SOD2↓, 1,   TrxR↓, 2,  

Metal & Cofactor Biology ⓘ

Ferritin↓, 1,   Tf↑, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   ATP↓, 3,   CDC2↓, 1,   MEK↓, 1,   MMP↓, 5,   MMP↑, 1,   mtDam↑, 1,   mt-OCR↓, 1,   Raf↓, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis ⓘ

12LOX↓, 2,   ACLY↓, 1,   AMPK↑, 6,   cMyc↓, 2,   ECAR↓, 1,   FASN↓, 1,   GAPDH↓, 1,   glucose↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 7,   H2S↑, 1,   HK2↓, 2,   HMG-CoA↓, 1,   LDH↓, 1,   LDL↓, 1,   NADPH↓, 1,   PKM2↓, 4,   PPP↓, 1,   PPP↑, 1,   p‑S6K↓, 1,   SIRT1↑, 1,  

Cell Death ⓘ

Akt↓, 7,   p‑Akt↓, 2,   Apoptosis↑, 20,   BAX↑, 4,   Bax:Bcl2↑, 2,   Bcl-2↓, 5,   Bcl-2↑, 1,   Casp↑, 2,   Casp1↑, 1,   Casp3↑, 5,   Casp8↑, 1,   Casp9↑, 2,   Cyt‑c↑, 2,   DR5↑, 2,   Fas↑, 1,   Ferroptosis↑, 2,   IAP1↓, 1,   JNK↑, 2,   MAPK↓, 3,   p27↑, 1,   p38↑, 1,   survivin↓, 2,   Telomerase↓, 2,   TumCD↑, 2,  

Kinase & Signal Transduction ⓘ

p‑CaMKII ↓, 1,   PAK↓, 1,  

Transcription & Epigenetics ⓘ

other↑, 1,   other↝, 2,   PhotoS↑, 1,   tumCV↓, 2,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 4,   HSP90↓, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 2,   mt-TumAuto↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 10,   DNMT1↓, 1,   P53↑, 3,   p‑P53↑, 1,   cl‑PARP↑, 1,   PCNA↓, 1,   γH2AX↑, 3,   γH2AX↝, 1,  

Cell Cycle & Senescence ⓘ

CDK1↑, 1,   CDK2↓, 1,   CDK2↑, 1,   CDK4↓, 2,   CDK4↑, 1,   CycB/CCNB1↓, 1,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 2,   cycE/CCNE↓, 2,   P21↑, 2,   Securin↓, 1,   TumCCA↓, 1,   TumCCA↑, 12,  

Proliferation, Differentiation & Cell State ⓘ

CD133↓, 1,   CD44↓, 1,   CSCs↓, 5,   Diff↓, 1,   Diff↑, 2,   EMT↓, 4,   ERK↓, 3,   FOXO↑, 1,   FOXO3↑, 1,   GSK‐3β↓, 1,   HMGCR↓, 2,   IGF-1R↓, 1,   mTOR↓, 5,   mTOR↑, 1,   p‑mTORC1↓, 1,   n-MYC↓, 1,   Nestin↓, 1,   NOTCH↓, 1,   NOTCH1↓, 1,   NOTCH3↓, 1,   OCT4↓, 1,   PI3K↓, 7,   PTEN↑, 1,   SOX2↓, 2,   STAT3↓, 5,   p‑STAT3↓, 1,   TumCG↓, 5,   TumCG↑, 1,   Wnt↓, 3,  

Migration ⓘ

AntiAg↑, 1,   AP-1↓, 1,   Ca+2↑, 1,   CEA↓, 1,   E-cadherin↓, 1,   E-cadherin↑, 1,   ER-α36↓, 1,   Furin↓, 1,   MMP2↓, 6,   MMP9↓, 5,   MMP9↑, 1,   MMPs↓, 1,   N-cadherin↓, 2,   Slug↓, 1,   Smad1↑, 1,   TGF-β↓, 1,   TGF-β↑, 1,   TumCI↓, 4,   TumCMig↓, 4,   TumCP↓, 6,   TumMeta↓, 3,   Twist↓, 1,   uPA↓, 1,   Vim↓, 2,   Zeb1↓, 1,   ZEB2↓, 1,   β-catenin/ZEB1↓, 5,  

Angiogenesis & Vasculature ⓘ

angioG↓, 2,   EGFR↓, 3,   EPR↝, 1,   HIF-1↓, 1,   Hif1a↓, 6,   Hif1a↑, 1,   TXA2↓, 1,   VEGF↓, 5,   VEGFR2↓, 1,  

Barriers & Transport ⓘ

BBB↑, 1,   CellMemb↑, 1,   GLUT1↓, 2,   GLUT3↓, 1,  

Immune & Inflammatory Signaling ⓘ

CCR7↓, 1,   COX1↓, 1,   COX2↓, 3,   COX2↑, 1,   CXCR4↓, 1,   IL1↑, 1,   IL1β↓, 1,   IL6↓, 3,   IL8↑, 1,   Imm↑, 1,   Inflam↓, 3,   JAK↝, 1,   JAK2↓, 2,   MCP1↓, 2,   NF-kB↓, 6,   NF-kB↑, 1,   p65↓, 1,   PD-L1↓, 2,   PGE2↓, 3,   RANTES↓, 1,   SOCS-3↑, 1,   TNF-α↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,   CDK6↓, 1,   CDK6↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 5,   BioAv↑, 1,   ChemoSen↑, 14,   Dose?, 1,   Dose↓, 2,   Dose↑, 2,   Dose↝, 4,   eff↓, 4,   eff↑, 24,   eff↝, 3,   Half-Life↓, 2,   RadioS↑, 51,   selectivity↑, 11,  

Clinical Biomarkers ⓘ

AR↓, 1,   CEA↓, 1,   EGFR↓, 3,   Ferritin↓, 1,   GutMicro↝, 1,   IL6↓, 3,   LDH↓, 1,   PD-L1↓, 2,  

Functional Outcomes ⓘ

AntiCan↑, 2,   AntiTum↑, 3,   cardioP↑, 1,   chemoP↑, 3,   chemoPv↑, 1,   neuroP↑, 1,   OS↑, 3,   QoL↑, 1,   radioP↑, 3,   toxicity↓, 3,   toxicity↑, 1,   toxicity∅, 1,   TumVol↓, 1,   TumW↓, 1,  
Total Targets: 236

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx?, 1,   GPx↑, 1,   lipid-P↓, 1,   MDA↓, 1,   NRF2↑, 2,   ROS↓, 4,   ROS↑, 1,   ROS∅, 1,   SOD↑, 1,   SOD2↑, 1,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 1,   p‑PPARγ↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

Diff↑, 1,  

Migration ⓘ

TGF-β↓, 1,  

Barriers & Transport ⓘ

BBB↝, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   IL10↑, 1,   IL18↓, 1,   IL1β↓, 1,   IL6↓, 1,   IL8↓, 1,   Inflam↓, 2,   NF-kB↓, 1,   TNF-α↓, 2,  

Synaptic & Neurotransmission ⓘ

AChE↓, 1,  

Protein Aggregation ⓘ

BACE↓, 1,  

Hormonal & Nuclear Receptors ⓘ

CYP19↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↝, 1,   Dose↑, 1,   eff↑, 1,   Half-Life↝, 2,  

Clinical Biomarkers ⓘ

ALP↓, 1,   AST↓, 1,   GutMicro↑, 1,   IL6↓, 1,  

Functional Outcomes ⓘ

AntiDiabetic↑, 1,   cardioP↑, 2,   chemoP↑, 1,   chemoPv↑, 1,   hepatoP↑, 1,   memory↑, 1,   neuroP↑, 2,   Obesity↓, 1,   toxicity↓, 2,  

Infection & Microbiome ⓘ

Bacteria↓, 2,   Inf↓, 1,  
Total Targets: 47

Scientific Paper Hit Count for: RadioS, RadioSensitizer
47 Radiotherapy/Radiation
10 Silver-NanoParticles
9 Curcumin
8 Betulinic acid
8 Propolis -bee glue
8 Resveratrol
7 Baicalein
6 Berberine
6 diet Methionine-Restricted Diet
5 Copper and Cu NanoParticles
5 salinomycin
5 Disulfiram
5 Ellagic acid
5 Fisetin
5 Thymoquinone
4 Chemotherapy
4 Atorvastatin
4 Honokiol
4 Magnetic Fields
4 Phenylbutyrate
4 Sulforaphane (mainly Broccoli)
3 Hyperthermia
3 Apigenin (mainly Parsley)
3 Ashwagandha(Withaferin A)
3 Cisplatin
3 brusatol
3 Dichloroacetate
3 diet FMD Fasting Mimicking Diet
3 Gold NanoParticles
3 Luteolin
3 Oxygen, Hyperbaric
3 Piperlongumine
3 Parthenolide
3 Selenium NanoParticles
2 3-bromopyruvate
2 Auranofin
2 Allicin (mainly Garlic)
2 Astaxanthin
2 Brucea javanica
2 Caffeic acid
2 Capsaicin
2 Caffeic Acid Phenethyl Ester (CAPE)
2 chemodynamic therapy
2 Celastrol
2 Chrysin
2 diet Short Term Fasting
2 EGCG (Epigallocatechin Gallate)
2 Ferulic acid
2 Gambogic Acid
2 Niclosamide (Niclocide)
2 Oleuropein
2 Quercetin
2 Rosmarinic acid
2 Sulfasalazine
2 Silymarin (Milk Thistle) silibinin
2 Selenite (Sodium)
2 Vitamin D3
1 2-DeoxyGlucose
1 Astragalus
1 Alpha-Lipoic-Acid
1 Anti-oxidants
1 Artemisinin
1 Aspirin -acetylsalicylic acid
1 Baicalin
1 Berbamine
1 Biochanin A
1 Bromelain
1 borneol
1 Boron
1 Black phosphorus
1 Butyrate
1 Zinc
1 Carvacrol
1 Thymol-Thymus vulgaris
1 carboplatin
1 Celecoxib
1 Coenzyme Q10
1 immunotherapy
1 Electrical Pulses
1 Hydroxycinnamic-acid
1 Magnolol
1 Melatonin
1 Metformin
1 HydroxyTyrosol
1 Piperine
1 Psoralidin
1 Oxaliplatin
1 Selenium
1 Shikonin
1 Urolithin
1 Vitamin K2
1 Zerumbone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1107  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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