CardioT Cancer Research Results

CardioT, Cardiotoxicity: Click to Expand ⟱
Source:
Type:
Cardiotoxicity in the context of cancer generally refers to the potential harmful effects that cancer therapies can have on the heart. This is an important consideration because many effective cancer treatments can also damage cardiac tissue, leading to short-term or long-term cardiovascular complications.

Mechanisms of Cardiotoxicity in Cancer Therapy
-Chemotherapy Agents:
     Anthracyclines (e.g., doxorubicin, epirubicin):
     Alkylating Agents (e.g., cyclophosphamide):
     Antimetabolites (e.g., 5-fluorouracil, capecitabine):
-Targeted Therapies:
    HER2 inhibitors (e.g., trastuzumab):
    Tyrosine Kinase Inhibitors (e.g., sunitinib, imatinib):
-Radiation Therapy:
    Thoracic irradiation:

Natural Products that may reduce Cardiotoxicity:
-Resveratrol
-Curcumin
-EGCG
-Quercetin
-Garlic Extract (Allicin)
-Omega-3 Fatty Acids: Fish oil (EPA and DHA), flaxseeds, chia seeds, walnuts.


Natural products like resveratrol, curcumin, EGCG, quercetin, garlic extract, and omega-3 fatty acids show potential in reducing cardiotoxicity by targeting oxidative stress, inflammation, and apoptotic pathways.
Scientific Papers found: Click to Expand⟱
5964- CEL,    Celecoxib pathways: pharmacokinetics and pharmacodynamics
- Review, Var, NA
COX2↓, *Pain↓, *Inflam↓, Apoptosis↑, TumCCA↑, angioG↓, ER Stress↑, VEGF↓, MMP9↓, PDK1↓, Akt↓, CA↓, CardioT↑,
5960- CEL,    Phase II, Randomized, Placebo-Controlled Trial of Neoadjuvant Celecoxib in Men With Clinically Localized Prostate Cancer: Evaluation of Drug-Specific Biomarkers
- Trial, Pca, NA
eff∅, Dose↝, CardioT↑,
5948- Cela,    Recent Trends in anti-tumor mechanisms and molecular targets of celastrol
TumCP↓, TumCCA↑, Apoptosis↑, TumAuto↑, TumCI↓, TumMeta↓, Imm↝, angioG↓, Cyt‑c↑, ROS↑, BAX↑, Casp3↑, Casp9↑, cl‑PARP↑, PrxII↓, ER Stress↑, mtDam↑, CHOP↑, Inflam↓, NF-kB↓, CXCR4↓, MMP9↓, IL6↓, TNF-α↓, HSP90↓, neuroP↑, STAT3↓, Prx↓, HO-1↑, eff↑, eff↑, BioAv↑, toxicity↑, CardioT↑, hepatoP↓,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

HO-1↑, 1,   Prx↓, 1,   PrxII↓, 1,   ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

mtDam↑, 1,  

Core Metabolism/Glycolysis ⓘ

PDK1↓, 1,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↑, 2,   BAX↑, 1,   Casp3↑, 1,   Casp9↑, 1,   Cyt‑c↑, 1,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   ER Stress↑, 2,   HSP90↓, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 1,  

DNA Damage & Repair ⓘ

cl‑PARP↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 2,  

Proliferation, Differentiation & Cell State ⓘ

STAT3↓, 1,  

Migration ⓘ

CA↓, 1,   MMP9↓, 2,   TumCI↓, 1,   TumCP↓, 1,   TumMeta↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 2,   VEGF↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   CXCR4↓, 1,   IL6↓, 1,   Imm↝, 1,   Inflam↓, 1,   NF-kB↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   Dose↝, 1,   eff↑, 2,   eff∅, 1,  

Clinical Biomarkers ⓘ

IL6↓, 1,  

Functional Outcomes ⓘ

CardioT↑, 3,   hepatoP↓, 1,   neuroP↑, 1,   toxicity↑, 1,  
Total Targets: 42

Pathway results for Effect on Normal Cells:


Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  

Functional Outcomes ⓘ

Pain↓, 1,  
Total Targets: 2

Scientific Paper Hit Count for: CardioT, Cardiotoxicity
2 Celecoxib
1 Celastrol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1108  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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