selectivity Cancer Research Results

selectivity, selectivity: Click to Expand ⟱

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Type:

The selectivity of cancer products (such as chemotherapeutic agents, targeted therapies, immunotherapies, and novel cancer drugs) refers to their ability to affect cancer cells preferentially over normal, healthy cells. High selectivity is important because it can lead to better patient outcomes by reducing side effects and minimizing damage to normal tissues.

Achieving high selectivity in cancer treatment is crucial for improving patient outcomes. It relies on pinpointing molecular differences between cancerous and normal cells, designing drugs or delivery systems that exploit these differences, and overcoming intrinsic challenges like tumor heterogeneity and resistance

Factors that affect selectivity:
1. Ability of Cancer cells to preferentially absorb a product/drug
-EPR-enhanced permeability and retention of cancer cells
-nanoparticle formations/carriers may target cancer cells over normal cells
-Liposomal formations. Also negatively/positively charged affects absorbtion

2. Product/drug effect may be different for normal vs cancer cells
- hypoxia
- transition metal content levels (iron/copper) change probability of fenton reaction.
- pH levels
- antiOxidant levels and defense levels

3. Bio-availability

Scientific Papers found: Click to Expand⟱

5271-

3BP,

The anticancer agent 3-bromopyruvate: a simple but powerful molecule taken from the lab to the bedside

-

Review,

Var,

NA

selectivity↑, selectivity↑, ATP↓, Glycolysis↓, HK2↓, mt-OXPHOS↓, GAPDH↓, mtDam↑, GSH↓, ROS↑, ER Stress↑, TumAuto↑, LC3‑Ⅱ/LC3‑Ⅰ↑, p62↓, Akt↓, HDAC↓, TumCA↑, Bcl-2↓, cMyc↓, Casp3↑, Cyt‑c↑, Mcl-1↓, PARP↓, ChemoSen↑,

5281-

3BP,

A translational study “case report” on the small molecule “energy blocker” 3-bromopyruvate (3BP) as a potent anticancer agent: from bench side to bedside

-

Case Report,

Var,

NA

Glycolysis↓, mt-OXPHOS↓, ATP↓, selectivity↑, toxicity↝, OS↑, QoL↑,

5280-

3BP,

Anticancer Efficacy of the Metabolic Blocker 3-Bromopyruvate: Specific Molecular Targeting

-

in-vitro,

PC,

NA

mtDam↑, HK2↓, TGF-β↓, Casp3↑, selectivity↑,

5278-

3BP,

The effect of 3-bromopyruvate on human colorectal cancer cells is dependent on glucose concentration but not hexokinase II expression

-

in-vitro,

CRC,

HCT116

-

in-vitro,

CRC,

Caco-2

-

in-vitro,

CRC,

SW48

ATP↓, TumCD↑, selectivity↑, toxicity↓, OS↑, HK2?, Cyt‑c↑, eff↑, p‑Akt↑,

5277-

3BP,

3-Bromopyruvate inhibits pancreatic tumor growth by stalling glycolysis, and dismantling mitochondria in a syngeneic mouse model

-

in-vivo,

PC,

Panc02

mouse model

HK2↓, selectivity↑, ATP↓, mtDam↑, Dose↝, TumCG↓, Casp3↑, Glycolysis↓, NADPH↓, ATP↓, ROS↑, DNAdam↑, GSH↓, Bcl-2↓, Casp↑, lactateProd↓,

5461-

AF,

Dual inhibition of thioredoxin reductase and proteasome is required for auranofin-induced paraptosis in breast cancer cells

-

in-vitro,

BC,

MDA-MB-231

-

in-vitro,

Nor,

MCF10

Paraptosis↑, ER Stress↑, TrxR↓, selectivity↑, toxicity↝, ROS↑, mt-TrxR1↓, mt-TrxR2↓,

5236-

AgNPs,

Adaptive regulations of Nrf2 alleviates silver nanoparticles-induced oxidative stress-related liver cells injury

-

in-vitro,

Liver,

HepG2

-

in-vitro,

Nor,

L02

tumCV↓, ROS↑, *ROS↑, DNAdam↑, *DNAdam↑, eff↓, selectivity↑,

5977-

AgNPs,

CDT,

Silver Nitroprusside as an Efficient Chemodynamic Therapeutic Agent and a Peroxynitrite nanogenerator for Targeted Cancer Therapy

-

in-vivo,

Ovarian,

A2780S

mouse

-

NA,

Ovarian,

SKOV3

Fenton↑, ROS↑, eff↑, angioG↓, p‑Akt↓, EPR↑, selectivity↑, selectivity↑, eff↑, Cyt‑c↑, HO-1↑,

4403-

AgNPs,

Silver Nanoparticles Decorated UiO-66-NH2 Metal-Organic Framework for Combination Therapy in Cancer Treatment

-

in-vitro,

GBM,

U251

-

in-vitro,

GBM,

U87MG

-

in-vitro,

GBM,

GL26

-

in-vitro,

Cerv,

HeLa

-

in-vitro,

CRC,

RKO

AntiCan↑, eff↑, EPR↑, selectivity↑, ROS↑, Casp↑, Apoptosis↑, DNAdam↑, tumCV↓, eff↑,

4402-

AgNPs,

Enhancement of Triple-Negative Breast Cancer-Specific Induction of Cell Death by Silver Nanoparticles by Combined Treatment with Proteotoxic Stress Response Inhibitors

-

in-vitro,

BC,

BT549

-

in-vitro,

BC,

MDA-MB-231

-

in-vitro,

Nor,

MCF10

TumCD↑, selectivity↑, *toxicity↝, Dose↝, OS↑,

4400-

AgNPs,

Rad,

Differential cytotoxic and radiosensitizing effects of silver nanoparticles on triple-negative breast cancer and non-triple-negative breast cells

-

in-vitro,

BC,

MCF-7

-

in-vitro,

Nor,

MCF10

-

in-vitro,

BC,

MDA-MB-231

-

in-vitro,

BC,

BT549

-

in-vivo,

BC,

MDA-MB-231

right hind flanks of the mice

ROS↑, DNAdam↑, selectivity↑, TumCG↓, RadioS↑, Dose↝, selectivity↑, other↝, eff↓, eff↑, γH2AX↑, Dose↓, eff↑,

4397-

AgNPs,

Synthesis and Characterization of Silver Nanoparticles from Rhizophora apiculata and Studies on Their Wound Healing, Antioxidant, Anti-Inflammatory, and Cytotoxic Activity

-

NA,

Wounds,

NA

 99 nm, with a zeta potential of −6 mV

selectivity↑, tumCV↓, antiOx↑, Inflam↓,

4388-

AgNPs,

Differential Cytotoxic Potential of Silver Nanoparticles in Human Ovarian Cancer Cells and Ovarian Cancer Stem Cells

-

in-vitro,

Cerv,

NA

47.5 nm

tumCV↓, CSCs↓, selectivity↑, Apoptosis↑, ROS↑, LDH↓, Casp3↑, BAX↑, Bak↑, cMyc↑, MMP↓,

4422-

AgNPs,

Bioengineering of Piper longum L. extract mediated silver nanoparticles and their potential biomedical applications

-

in-vitro,

Cerv,

HeLa

AntiCan↑, selectivity↑,

4421-

AgNPs,

Effect of Biologically Synthesized Silver Nanoparticles on Human Cancer Cells

-

in-vitro,

Cerv,

NA

selectivity↑, eff↝, other↝,

4413-

AgNPs,

Anzaroot,

Green synthesis of silver nanoparticles from plant Astragalus fasciculifolius Bioss and evaluating cytotoxic effects on MCF7 human breast cancer cells

-

in-vitro,

BC,

MCF-7

12.35 μg/mL

The IC50 value for root extract-mediated SNPs was found to be 21.73 μg/mL

chemoP↑, TumCG↓, eff↑, CellMemb↑, selectivity↑, ROS↑, P53↑,

4411-

AgNPs,

Eco-friendly synthesis of silver nanoparticles using Anemone coronaria bulb extract and their potent anticancer and antibacterial activities

-

in-vitro,

Lung,

A549

-

in-vitro,

PC,

MIA PaCa-2

-

in-vitro,

Pca,

PC3

-

in-vitro,

Nor,

HEK293

AntiCan↑, selectivity↑, Apoptosis↑, TumCCA↑, Bacteria↓, tumCV↓, selectivity↑, Apoptosis↑, TumCCA↑,

4410-

AgNPs,

Green-synthesized silver nanoparticles: a sustainable nanoplatform for targeted colon cancer therapy

-

Review,

Colon,

NA

AntiCan↑, ROS↑, mtDam↑, tumCV↓, selectivity↑,

4431-

AgNPs,

doxoR,

Oxidative Stress-Induced Silver Nano-Carriers for Chemotherapy

-

in-vitro,

BC,

4T1

PA-AgNPs have an average hydrodynamic diameter of 130 nm

-

in-vivo,

BC,

4T1

-

in-vitro,

Nor,

3T3

AntiCan↑, ROS↑, TumVol↓, EPR↑, selectivity↑, ChemoSen↑,

4429-

AgNPs,

Comparative proteomic analysis reveals the different hepatotoxic mechanisms of human hepatocytes exposed to silver nanoparticles

-

in-vitro,

Liver,

HepG2

*toxicity↝, selectivity↑, mt-ROS↑,

4363-

AgNPs,

Immunomodulatory properties of silver nanoparticles contribute to anticancer strategy for murine fibrosarcoma

-

in-vivo,

fibroS,

NA

particles was approximately 10 nm

LACA mice

TumVol↓, TNF-α↓, IL6↓, IL1β↓, *toxicity↝, TumCG↓, selectivity↑, selectivity↑, Weight↑, ROS↑, NO↑,

4433-

AgNPs,

Advancements in metal and metal oxide nanoparticles for targeted cancer therapy and imaging: Mechanisms, applications, and safety concerns

-

in-vitro,

Liver,

HepG2

-

in-vitro,

Nor,

L02

selectivity↑, selectivity↓, mt-ROS↑,

4435-

AgNPs,

Gluc,

Glucose-Functionalized Silver Nanoparticles as a Potential New Therapy Agent Targeting Hormone-Resistant Prostate Cancer cells

-

in-vitro,

Pca,

PC3

average size of 61nm

911ug/mL

-

in-vitro,

Pca,

LNCaP

-

in-vitro,

Pca,

DU145

1579ug/mL

selectivity↑, ROS↑, mtDam↑, TumCCA↑, TumCP↓, Apoptosis↑, MMP↓,

4364-

AgNPs,

Selective cytotoxicity of green synthesized silver nanoparticles against the MCF-7 tumor cell line and their enhanced antioxidant and antimicrobial properties

-

in-vitro,

BC,

MCF-7

31.4 nm with a Zeta potential of −33.8 mV,

TumCD↑, selectivity↑, *antiOx↑, *Inflam↓, AntiTum↑, ROS↑,

4376-

AgNPs,

Interaction of multi-functional silver nanoparticles with living cells

-

in-vitro,

Nor,

L929

-

in-vitro,

Lung,

A549

eff↑, selectivity↑,

4371-

AgNPs,

Effects of Green Silver Nanoparticles on Apoptosis and Oxidative Stress in Normal and Cancerous Human Hepatic Cells in vitro

-

in-vitro,

Liver,

HUH7

20−50 nm

eco-friendly approach silver nanoparticles (AgNPs) using root extracts of Beta vulgaris L.

ROS↑, selectivity↑, DNAdam↑, Apoptosis↑, GSH↓, lipid-P↑, MMP↓, DNAdam↑,

4365-

AgNPs,

Biomedical Applications of Silver Nanoparticles: An Up-to-Date Overview

-

Review,

Var,

NA

ROS↑, *toxicity↓, *Bacteria↓, *Inf↓, *Diff↑, *eff↑, RadioS↑, selectivity↑,

4561-

AgNPs,

VitC,

Cellular Effects Nanosilver on Cancer and Non-cancer Cells: Potential Environmental and Human Health Impacts

-

in-vitro,

CRC,

HCT116

-

in-vitro,

Nor,

HEK293

NRF2↑, TumCCA↑, ROS↑, selectivity↑, *AntiViral↑, *toxicity↝, ETC↓, MMP↓, DNAdam↑, Apoptosis↑, lipid-P↑, other↝, UPR↑, *GRP78/BiP↑, *p‑PERK↑, *cl‑eIF2α↑, *CHOP↑, *JNK↑, Hif1a↓, AntiCan↑, *toxicity↓, eff↑,

4558-

AgNPs,

Role of Oxidative and Nitro-Oxidative Damage in Silver Nanoparticles Cytotoxic Effect against Human Pancreatic Ductal Adenocarcinoma Cells

-

in-vitro,

PC,

PANC1

3.19 ug/mL

ROS↑, selectivity↑, NO↑, SOD↓, GPx4↓, Catalase↓, TumCCA↑, MMP↓,

4555-

AgNPs,

Silver nanoparticles from Dendropanax morbifera Léveille inhibit cell migration, induce apoptosis, and increase generation of reactive oxygen species in A549 lung cancer cells

-

in-vitro,

Lung,

A549

-

in-vitro,

Liver,

HepG2

*Bacteria↓, tumCV↓, selectivity↑, ROS↑, Apoptosis↑, TumCMig↓, AntiCan↑,

4541-

AgNPs,

RosA,

Eco-friendly synthesis of silver nanoparticles: multifaceted antioxidant, antidiabetic, anticancer, and antimicrobial activities

-

in-vitro,

Nor,

WI38

-

in-vitro,

BC,

MDA-MB-231

-

in-vitro,

PC,

PANC1

*antiOx↑, TumCD↓, selectivity↑,

4540-

AgNPs,

VitC,

Silver nanoparticles from ascorbic acid: Biosynthesis, characterization, in vitro safety profile, antimicrobial activity and phytotoxicity

-

in-vitro,

Nor,

NA

*Bacteria↓, *selectivity↑,

4584-

AgNPs,

Silver Nanoparticles Synthesized Using Carica papaya Leaf Extract (AgNPs-PLE) Causes Cell Cycle Arrest and Apoptosis in Human Prostate (DU145) Cancer Cells

-

in-vitro,

Pca,

DU145

selectivity↑, ROS↑, BAX↑, cl‑Casp3↑, p‑PARP↑, TumCCA↑, cycD1/CCND1↓, p27↑, P21↑, AntiCan↑,

4573-

AgNPs,

Bioactive silver nanoparticles derived from Carica papaya floral extract and its dual-functioning biomedical application

-

in-vitro,

Var,

MCF-7

21.25 ± 1.14 µg/mL

-

NA,

NA,

HEK293

169.96 ± 2.3 µg/mL

toxicity↓, Bacteria↓, selectivity↑,

5147-

AgNPs,

Size dependent anti-invasiveness of silver nanoparticles in lung cancer cells

-

in-vitro,

Lung,

A549

TumCMig↓, TumCI↓, ROS↑, p‑NF-kB↑, selectivity↑, eff↝,

5145-

AgNPs,

Silver nanoparticles induce irremediable endoplasmic reticulum stress leading to unfolded protein response dependent apoptosis in breast cancer cells

-

in-vitro,

BC,

MCF-7

-

in-vitro,

BC,

T47D

Bacteria↓, Apoptosis↑, ER Stress↑, UPR↑, PERK↑, IRE1↑, ATF6↑, ATF4↑, CHOP↑, Casp9↑, Casp7↑, Mcl-1↓, XIAP↓, PARP↝, selectivity↑,

375-

AgNPs,

ALA,

Alpha-Lipoic Acid Prevents Side Effects of Therapeutic Nanosilver without Compromising Cytotoxicity in Experimental Pancreatic Cancer

-

in-vitro,

PC,

Bxpc-3

 we used α-lipoic acid concentrations of 0.5 and 1 mM

-

in-vitro,

PC,

PANC1

-

in-vitro,

PC,

MIA PaCa-2

-

in-vivo,

NA,

NA

dropping 200 µL or 400 µL of a 14 ppm AgNP solution, 200 µL or 400 µL of a 0.5 mM α-lipoic acid solution, or both solutions together on the chorioallantoic membrane (CAM)

chick embryos

mtDam↑, ROS↑, *toxicity↓, Dose∅, selectivity↑,

5340-

Ajoene,

Ajoene, a compound of garlic, induces apoptosis in human promyeloleukemic cells, accompanied by generation of reactive oxygen species and activation of nuclear factor kappaB

-

in-vitro,

AML,

NA

Apoptosis↑, selectivity↑, H2O2↑, NF-kB↑,

5356-

AL,

Therapeutic role of allicin in gastrointestinal cancers: mechanisms and safety aspects

-

Review,

GC,

NA

Apoptosis↑, TumCP↓, MAPK↓, PI3K↓, Akt↓, NF-kB↓, AntiCan↑, ChemoSen↑, TumCCA↑, Apoptosis↑, BioAv↑, selectivity↑, TGF-β↓, ROS↑, DNAdam↑, p‑P53↑, P21↑, cycD1/CCND1↓, cycE/CCNE↓, CDK4↓, CDK6↓, MMP↓, NF-kB↑, BAX↑, Bcl-2↓, ER Stress↑, Casp↑, AIF↑, Fas↑, Casp8↑, Cyt‑c↑, cl‑PARP↑, Ca+2↑, *NRF2↑, *chemoP↑, *GutMicro↑, CycB/CCNB1↑, H2S↑, HIF-1↓, RadioS↑,

2000-

AL,

Exploring the ROS-mediated anti-cancer potential in human triple-negative breast cancer by garlic bulb extract: A source of therapeutically active compounds

-

in-vitro,

BC,

MDA-MB-231

5–20 mg/mL

13.69 mg/mL

-

in-vitro,

BC,

MCF-7

5–20 mg/mL5–20 mg/mL

15.35 mg/mL

-

in-vitro,

Nor,

NA

selectivity↑, TumCG?, *toxicity∅, ROS↑, MMP↓, TumCCA↑, P53↑, Bcl-2↓, p‑Akt↓, p‑p38↓, *ROS∅,

234-

AL,

Allicin Induces Anti-human Liver Cancer Cells through the p53 Gene Modulating Apoptosis and Autophagy

-

in-vitro,

HCC,

Hep3B

 0, 15, 20, 25, 35, 40 and 50 Î¼M of allicin for 24 h

 35 uM @24h

ROS↑, *toxicity∅, MMP↓, BAX↑, Bcl-2↓, AIF↑, Casp3↑, Casp8↑, Casp9↑, eff↓, γH2AX↑, selectivity↑, DNA-PK↑,

3442-

ALA,

α‑lipoic acid modulates prostate cancer cell growth and bone cell differentiation

-

in-vitro,

Pca,

22Rv1

-

in-vitro,

Pca,

C4-2B

-

in-vitro,

Nor,

3T3

tumCV↓, TumCMig↓, TumCI↓, ROS↑, Hif1a↑, JNK↑, Casp↑, TumCCA↑, Apoptosis↑, selectivity↑,

3454-

ALA,

Lipoic acid blocks autophagic flux and impairs cellular bioenergetics in breast cancer and reduces stemness

-

in-vitro,

BC,

MCF-7

(0.5 mM, 1 mM, 2.5 mM, and 5 mM)

-

in-vitro,

BC,

MDA-MB-231

TumCG↑, Glycolysis↓, ROS↑, CSCs↓, selectivity↑, LC3B-II↑, MMP↓, mitResp↓, ATP↓, OCR↓, NAD↓, p‑AMPK↑, GlucoseCon↓, lactateProd↓, HK2↓, PFK↓, LDHA↓, eff↓, mTOR↓, ECAR↓, ALDH↓, CD44↓, CD24↓,

278-

ALA,

The Multifaceted Role of Alpha-Lipoic Acid in Cancer Prevention, Occurrence, and Treatment

-

Review,

NA,

NA

ROS↑, NRF2↑, Inflam↓, frataxin↑, *BioAv↓, ChemoSen↑, Hif1a↓, eff↑, FAK↓, ITGB1↓, MMP2↓, MMP9↓, EMT↓, Snail↓, Vim↓, Zeb1↓, P53↑, MGMT↓, Mcl-1↓, Bcl-xL↓, Bcl-2↓, survivin↓, Casp3↑, Casp9↑, BAX↑, p‑Akt↓, GSK‐3β↓, *antiOx↑, *ROS↓, selectivity↑, angioG↓, MMPs↓, NF-kB↓, ITGB3↓, NADPH↓,

5326-

ALC,

L-Carnitine Is an Endogenous HDAC Inhibitor Selectively Inhibiting Cancer Cell Growth In Vivo and In Vitro

-

vitro+vivo,

Liver,

HepG2

mice

TumCG↓, P21↑, ac‑H3↑, HDAC↓, *ATP↑, selectivity↑, ac‑H4↑,

1999-

Api,

doxoR,

Apigenin ameliorates doxorubicin-induced renal injury via inhibition of oxidative stress and inflammation

-

in-vitro,

Nor,

NRK52E

-

in-vitro,

Nor,

MPC5

-

in-vitro,

BC,

4T1

-

in-vivo,

NA,

NA

APG (125, 250, and 500 mg/kg) for two weeks,

mice

neuroP↑, ChemoSen∅, RenoP↑, selectivity↑, chemoP↑, ROS↑, *ROS∅, *antiOx↑, *toxicity↓,

1548-

Api,

A comprehensive view on the apigenin impact on colorectal cancer: Focusing on cellular and molecular mechanisms

-

Review,

Colon,

NA

*BioAv↓, *Half-Life∅, selectivity↑, *toxicity↓, Wnt/(β-catenin)↓, P53↑, P21↑, PI3K↓, Akt↓, mTOR↓, TumCCA↑, TumCI↓, TumCMig↓, STAT3↓, PKM2↓, EMT↓, cl‑PARP↑, Casp3↑, Bax:Bcl2↑, VEGF↓, Hif1a↓, Dose∅, GLUT1↓, GlucoseCon↓,

1559-

Api,

Dually Active Apigenin-Loaded Nanostructured Lipid Carriers for Cancer Treatment

-

in-vitro,

Lung,

A549

-

in-vitro,

BC,

MCF-7

-

in-vitro,

BC,

MDA-MB-231

Dose↓, selectivity↑,

1563-

Api,

MET,

Metformin-induced ROS upregulation as amplified by apigenin causes profound anticancer activity while sparing normal cells

-

in-vitro,

Nor,

HDFa

metformin (5 mM), apigenin (1 or 20 µM),

-

in-vitro,

PC,

AsPC-1

-

in-vitro,

PC,

MIA PaCa-2

-

in-vitro,

Pca,

DU145

-

in-vitro,

Pca,

LNCaP

-

in-vivo,

NA,

NA

mice

selectivity↑, selectivity↑, selectivity↓, ROS↑, eff↑, tumCV↓, MMP↓, Dose∅, eff↓, DNAdam↑, Apoptosis↑, TumAuto↑, Necroptosis↑, p‑P53↑, BIM↑, BAX↑, p‑PARP↑, Casp3↑, Casp8↑, Casp9↑, Cyt‑c↑, Bcl-2↓, AIF↑, p62↑, LC3B↑, MLKL↑, p‑MLKL↓, RIP3↑, p‑RIP3↑, TumCG↑, TumW↓,

2584-

Api,

Chemo,

The versatility of apigenin: Especially as a chemopreventive agent for cancer

-

Review,

Var,

NA

ChemoSen↑, RadioS↑, eff↝, DR5↑, selectivity↑, angioG↓, selectivity↑, chemoP↑, MAPK↓, PI3K↓, Akt↓, mTOR↓, Wnt↓, β-catenin/ZEB1↓, GLUT1↓, radioP↑, BioAv↓, chemoPv↑,

Showing Research Papers: 1 to 50 of 422
Page 1 of 9 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 422

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress ⓘ

antiOx↑, 1, Catalase↓, 1, Fenton↑, 1, frataxin↑, 1, GPx4↓, 1, GSH↓, 3, H2O2↑, 1, HO-1↑, 1, lipid-P↑, 2, NRF2↑, 2, mt-OXPHOS↓, 2, ROS↑, 30, mt-ROS↑, 2, SOD↓, 1, TrxR↓, 1, mt-TrxR1↓, 1, mt-TrxR2↓, 1,

Mitochondria & Bioenergetics ⓘ

AIF↑, 3, ATP↓, 6, ETC↓, 1, mitResp↓, 1, MMP↓, 10, mtDam↑, 6, OCR↓, 1, XIAP↓, 1,

Core Metabolism/Glycolysis ⓘ

p‑AMPK↑, 1, cMyc↓, 1, cMyc↑, 1, ECAR↓, 1, GAPDH↓, 1, GlucoseCon↓, 2, Glycolysis↓, 4, H2S↑, 1, HK2?, 1, HK2↓, 4, lactateProd↓, 2, LDH↓, 1, LDHA↓, 1, NAD↓, 1, NADPH↓, 2, PFK↓, 1, PKM2↓, 1,

Cell Death ⓘ

Akt↓, 4, p‑Akt↓, 3, p‑Akt↑, 1, Apoptosis↑, 14, Bak↑, 1, BAX↑, 6, Bax:Bcl2↑, 1, Bcl-2↓, 7, Bcl-xL↓, 1, BIM↑, 1, Casp↑, 4, Casp3↑, 8, cl‑Casp3↑, 1, Casp7↑, 1, Casp8↑, 3, Casp9↑, 4, Cyt‑c↑, 5, DR5↑, 1, Fas↑, 1, JNK↑, 1, MAPK↓, 2, Mcl-1↓, 3, MLKL↑, 1, p‑MLKL↓, 1, Necroptosis↑, 1, p27↑, 1, p‑p38↓, 1, Paraptosis↑, 1, survivin↓, 1, TumCD↓, 1, TumCD↑, 3,

Transcription & Epigenetics ⓘ

ac‑H3↑, 1, ac‑H4↑, 1, other↝, 3, tumCV↓, 9,

Protein Folding & ER Stress ⓘ

ATF6↑, 1, CHOP↑, 1, ER Stress↑, 4, IRE1↑, 1, PERK↑, 1, UPR↑, 2,

Autophagy & Lysosomes ⓘ

LC3‑Ⅱ/LC3‑Ⅰ↑, 1, LC3B↑, 1, LC3B-II↑, 1, p62↓, 1, p62↑, 1, TumAuto↑, 2,

DNA Damage & Repair ⓘ

DNA-PK↑, 1, DNAdam↑, 9, MGMT↓, 1, P53↑, 4, p‑P53↑, 2, PARP↓, 1, PARP↝, 1, p‑PARP↑, 2, cl‑PARP↑, 2, γH2AX↑, 2,

Cell Cycle & Senescence ⓘ

CDK4↓, 1, CycB/CCNB1↑, 1, cycD1/CCND1↓, 2, cycE/CCNE↓, 1, P21↑, 4, TumCCA↑, 10,

Proliferation, Differentiation & Cell State ⓘ

ALDH↓, 1, CD24↓, 1, CD44↓, 1, CSCs↓, 2, EMT↓, 2, GSK‐3β↓, 1, HDAC↓, 2, mTOR↓, 3, PI3K↓, 3, STAT3↓, 1, TumCG?, 1, TumCG↓, 5, TumCG↑, 2, Wnt↓, 1, Wnt/(β-catenin)↓, 1,

Migration ⓘ

Ca+2↑, 1, FAK↓, 1, ITGB1↓, 1, ITGB3↓, 1, MMP2↓, 1, MMP9↓, 1, MMPs↓, 1, RIP3↑, 1, p‑RIP3↑, 1, Snail↓, 1, TGF-β↓, 2, TumCA↑, 1, TumCI↓, 3, TumCMig↓, 4, TumCP↓, 2, Vim↓, 1, Zeb1↓, 1, β-catenin/ZEB1↓, 1,

Angiogenesis & Vasculature ⓘ

angioG↓, 3, ATF4↑, 1, EPR↑, 3, HIF-1↓, 1, Hif1a↓, 3, Hif1a↑, 1, NO↑, 2, VEGF↓, 1,

Barriers & Transport ⓘ

CellMemb↑, 1, GLUT1↓, 2,

Immune & Inflammatory Signaling ⓘ

IL1β↓, 1, IL6↓, 1, Inflam↓, 2, NF-kB↓, 2, NF-kB↑, 2, p‑NF-kB↑, 1, TNF-α↓, 1,

Hormonal & Nuclear Receptors ⓘ

Drug Metabolism & Resistance ⓘ

BioAv↓, 1, BioAv↑, 1, ChemoSen↑, 5, ChemoSen∅, 1, Dose↓, 2, Dose↝, 3, Dose∅, 3, eff↓, 5, eff↑, 12, eff↝, 3, RadioS↑, 4, selectivity↓, 2, selectivity↑, 56,

Clinical Biomarkers ⓘ

IL6↓, 1, LDH↓, 1,

Functional Outcomes ⓘ

AntiCan↑, 9, AntiTum↑, 1, chemoP↑, 3, chemoPv↑, 1, neuroP↑, 1, OS↑, 3, QoL↑, 1, radioP↑, 1, RenoP↑, 1, toxicity↓, 2, toxicity↝, 2, TumVol↓, 2, TumW↓, 1, Weight↑, 1,

Infection & Microbiome ⓘ

Bacteria↓, 3,
Total Targets: 186

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

antiOx↑, 4, NRF2↑, 1, ROS↓, 1, ROS↑, 1, ROS∅, 2,

Mitochondria & Bioenergetics ⓘ

Cell Death ⓘ

Protein Folding & ER Stress ⓘ

CHOP↑, 1, cl‑eIF2α↑, 1, GRP78/BiP↑, 1, p‑PERK↑, 1,

DNA Damage & Repair ⓘ

Proliferation, Differentiation & Cell State ⓘ

Immune & Inflammatory Signaling ⓘ

Drug Metabolism & Resistance ⓘ

BioAv↓, 2, eff↑, 1, Half-Life∅, 1, selectivity↑, 1,

Clinical Biomarkers ⓘ

GutMicro↑, 1,

Functional Outcomes ⓘ

chemoP↑, 1, toxicity↓, 5, toxicity↝, 4, toxicity∅, 2,

Infection & Microbiome ⓘ

AntiViral↑, 1, Bacteria↓, 3, Inf↓, 1,
Total Targets: 26

Scientific Paper Hit Count for: selectivity, selectivity

33 Silver-NanoParticles
27 Magnetic Fields
17 Piperlongumine
13 Selenium NanoParticles
13 Thymoquinone
12 Betulinic acid
11 Radiotherapy/Radiation
11 Chemotherapy
10 Phenethyl isothiocyanate
10 Shikonin
9 Vitamin C (Ascorbic Acid)
9 Capsaicin
9 Propolis -bee glue
9 chitosan
9 salinomycin
8 Carvacrol
8 Copper and Cu NanoParticles
8 Dichloroacetate
8 Honokiol
8 Magnetic Field Rotating
8 Quercetin
8 Selenite (Sodium)
7 doxorubicin
7 Artemisinin
7 Berberine
7 Sulforaphane (mainly Broccoli)
6 Apigenin (mainly Parsley)
6 Baicalein
6 EGCG (Epigallocatechin Gallate)
6 Fisetin
6 Hydrogen Gas
5 3-bromopyruvate
5 Rosmarinic acid
5 Ashwagandha(Withaferin A)
5 Melatonin
5 Curcumin
5 Cisplatin
5 Selenium
5 HydroxyTyrosol
4 Alpha-Lipoic-Acid
4 Metformin
4 Phenylbutyrate
4 Boron
4 diet FMD Fasting Mimicking Diet
4 Ellagic acid
4 Lycopene
4 Magnolol
4 VitK3,menadione
3 chemodynamic therapy
3 Allicin (mainly Garlic)
3 Astaxanthin
3 Atorvastatin
3 Caffeic acid
3 Chrysin
3 Citric Acid
3 diet Methionine-Restricted Diet
3 Shilajit/Fulvic Acid
3 γ-linolenic acid (Borage Oil)
3 Parthenolide
3 Urolithin
2 Dipyridamole
2 Berbamine
2 Gold NanoParticles
2 Bifidobacterium
2 immunotherapy
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Coenzyme Q10
2 Hydroxycinnamic-acid
2 Date Fruit Extract
2 Oxygen, Hyperbaric
2 Disulfiram
2 Electrical Pulses
2 Fenbendazole
2 Gambogic Acid
2 Graviola
2 Luteolin
2 SonoDynamic Therapy UltraSound
2 Sulfasalazine
2 polyethylene glycol
2 Silymarin (Milk Thistle) silibinin
2 Aflavin-3,3′-digallate
2 Zerumbone
1 Auranofin
1 Anzaroot, Astragalus fasciculifolius Bioss
1 Glucose
1 Ajoene (compound of Garlic)
1 Acetyl-l-carnitine
1 Sorafenib (brand name Nexavar)
1 5-Aminolevulinic acid
1 Baicalin
1 Bufalin/Huachansu
1 probiotics
1 Brucea javanica
1 Boswellia (frankincense)
1 Butyrate
1 Carnosic acid
1 urea
1 Thymol-Thymus vulgaris
1 Cat’s Claw
1 Cannabidiol
1 Chocolate
1 Calorie Restriction Mimetics
1 diet Ketogenic
1 PXD, phenoxodiol
1 Emodin
1 Juglone
1 Methylene blue
1 Methyl Jasmonate
1 Methylglyoxal
1 Bicarbonate(Sodium)
1 Nimbolide
1 Oleuropein
1 Hyperthermia
1 Propyl gallate
1 temozolomide
1 borneol
1 Plumbagin
1 Psoralidin
1 Pterostilbene
1 Resveratrol
1 irinotecan
1 Ursolic acid
1 Vitamin B1/Thiamine
1 Vitamin K2

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1110  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

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