HLA Cancer Research Results

HLA, Human Leukocyte Antigen (HLA) molecules: Click to Expand ⟱
Source:
Type:
Human Leukocyte Antigen (HLA) molecules play a critical role in immune recognition, antigen presentation, and the regulation of immune responses.

• HLA class I molecules (e.g., HLA-A, -B, -C) are expressed on nearly all nucleated cells and present endogenous antigens to CD8⁺ cytotoxic T lymphocytes.
• Downregulation or loss of HLA class I expression is a common immune evasion strategy employed by tumors.

• Reduced HLA class I levels have been associated with poorer prognosis in several cancers, such as melanoma, colorectal, and lung cancers, because low expression hampers recognition and killing of tumor cells by cytotoxic T cells.

• HLA class II molecules (e.g., HLA-DR, -DP, -DQ) are typically expressed on professional antigen-presenting cells but can also be expressed on certain tumor cells.

HLA expression significantly influences tumor-immune interactions and, by extension, patient prognosis. While reduced HLA class I expression generally correlates with immune escape and poorer outcomes, the prognostic impact of HLA class II is more context-dependent and may vary by tumor type.
Scientific Papers found: Click to Expand⟱
1632- GAR,    Garcinia Cambogia, Either Alone or in Combination with Green Tea Causes Moderate to Severe Liver Injury
- Human, LiverDam, NA
HLA↑, The presence of HLA-B*35:01 allele was significantly higher in the G. cambogia containing HDS (55%) compared to patients due to other HDS (19%)
other↑, The liver injury caused by G. cambogia and green tea is clinically indistinguishable. The possible association with HLA-B*35:01 allele suggests an immune-mediated mechanism of injury

1489- RES,    Molecular mechanisms of resveratrol as chemo and radiosensitizer in cancer
- Review, Var, NA
RadioS↑,
ChemoSen↑,
*BioAv↓, However, in vivo experimental models have demonstrated that RSV is rapidly metabolized and eliminated, which leads to low bioavailability of the compound. 75% of RSV has been shown to be absorbed orally, only 1% is detected in the blood plasma
*BioAv↑, nanocarrier of RSV-loaded poly (ε-caprolactone)-poly (ethylene glycol) nanoparticles with an erythrocyte membrane. This system improved RSV’s poor water solubility
Ferroptosis↑, SV could induce ferroptotic cell death in colorectal cancer by initiating lipid peroxidation and suppressing the expression of SLC7A11 and GPX4
lipid-P↑,
xCT↓,
GPx4↓,
*BioAv↑, Bioactive or bioenhancer compounds have also been used (piperine, quercetin, biflavone ginkgetin) that, in combination with RSV, improve bioavailability, solubility, absorption, and cellular permeability
COX2↓, inhibiting Cyclooxygenase-COX
cycD1/CCND1↓,
FasL↓,
FOXP3↓,
HLA↑,
p‑NF-kB↓, decrease NF-ĸB phosphorylation
BAX↑,
Bcl-2↓,
MALAT1↓, decrease the expression of the lncRNA MALAT1 in colorectal and gastric cancer cells through the Wnt/β-catenin signaling pathway


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Ferroptosis↑, 1,   GPx4↓, 1,   lipid-P↑, 1,   xCT↓, 1,  

Cell Death ⓘ

BAX↑, 1,   Bcl-2↓, 1,   FasL↓, 1,   Ferroptosis↑, 1,  

Transcription & Epigenetics ⓘ

other↑, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,  

Migration ⓘ

HLA↑, 2,   MALAT1↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   FOXP3↓, 1,   p‑NF-kB↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   RadioS↑, 1,  
Total Targets: 17

Pathway results for Effect on Normal Cells:


Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 2,  
Total Targets: 2

Scientific Paper Hit Count for: HLA, Human Leukocyte Antigen (HLA) molecules
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1116  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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