CYP3A4 Cancer Research Results

CYP3A4, CYP3A4: Click to Expand ⟱

Source:

Type:

CYP3A4 is the most abundant cytochrome P450 enzyme in the liver and is also expressed in extrahepatic tissues.
– It metabolizes a wide range of drugs and endogenous substrates, including hormones.

– In some studies, higher CYP3A4 expression has been correlated with poorer response to treatment and potentially worse survival.

Scientific Papers found: Click to Expand⟱

5442-

AG,

Ome,

Effects of astragaloside IV on the pharmacokinetics of omeprazole in rats

in-vivo,

Nor,

orally administered omeprazole (2 mg/kg), with or without AS-IV (100 mg/kg/day for 7 days) pretreatment

male Sprague-Dawley rats

*other?, *P-gp↑, *CYP3A4↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Total Targets: 0

Pathway results for Effect on Normal Cells:

Core Metabolism/Glycolysis ⓘ

CYP3A4↑, 1,

Transcription & Epigenetics ⓘ

other?, 1,

Barriers & Transport ⓘ

P-gp↑, 1,
Total Targets: 3

Scientific Paper Hit Count for: CYP3A4, CYP3A4

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells