GFR Cancer Research Results

GFR, glomerular filtration rate: Click to Expand ⟱
Source:
Type:
Glomerular filtration rate—is primarily a clinical measure of kidney function rather than a molecular marker expressed by tumor cells.

GFR as an Indicator of Overall Patient Health and Tolerance to Therapy
– GFR is routinely measured in patients with cancer, especially because many anticancer therapies (such as chemotherapy agents, targeted therapies, and immunotherapies) are renally excreted or can be nephrotoxic.

– Lower GFR has been linked with poorer outcomes in various cancer types (for example, in patients with metastatic cancers, hematologic malignancies, or those undergoing major surgery) because it can limit the dosing and administration of effective therapies.

– Poor kidney function (low GFR) may be an indicator of frailty or overall decreased organ reserve, which in turn can correlate with worse overall survival and increased mortality.
Scientific Papers found: Click to Expand⟱
5619- NaHCO3,    Safety and efficacy of sodium bicarbonate for treating metabolic acidosis in chronic kidney disease: A systematic review and meta-analysis
- Review, CKD, NA
*eff↑, Sodium bicarbonate therapy may halt worsening kidney function by correcting serum bicarbonate levels and treating MA
toxicity↓, Compared to the comparison group, treatment with sodium bicarbonate did not significantly increase the risk of GI disorders, as reported by three trials.
GFR↑, A recently conducted meta-analysis[37] shows that sodium bicarbonate has a decreasing effect on the decline of eGFR
toxicity↝, However, edema was found to be a significant side effect of sodium bicarbonate supplementation.

1658- PBG,    Body Fluid pH Balance in Metabolic Health and Possible Benefits of Dietary Alkaline Foods
- Review, Var, NA
pH↑, pH of ascites and interstitial fluids around metabolic tissues is improved (elevated) by the intake of propolis compared with normal diet
GFR↑, improved the estimated glomerular filtration rate

2133- TQ,  CUR,  Cisplatin,    Thymoquinone and curcumin combination protects cisplatin-induced kidney injury, nephrotoxicity by attenuating NFκB, KIM-1 and ameliorating Nrf2/HO-1 signalling
- in-vitro, Nor, HEK293 - in-vivo, NA, NA
*creat↓, BUN, creatinine, CK and pro-inflammatory cytokines like TNF-α, IL-6 and MRP-1 to be elevated in the cisplatin-treated group while reducing glomerular filtration rate. Tq + Cur treatment significantly improved these conditions.
*TNF-α↓,
*IL6↓,
*MRP↓,
*GFR↑,
*mt-ATPase↑, antioxidant enzyme levels and mitochondrial ATPases were restored upon treatment,
*p‑Akt↑, Tq + Cur treatment increased the expressions of phosphorylated Akt, Nrf2 and HO-1 proteins while decreasing the levels of cleaved caspase 3 and NFκB in kidney homogenates.
*NRF2↑,
*HO-1↑,
*Casp3↓,
*NF-kB↓,
*RenoP↑, In summary, Tq + Cur had protective effects on cisplatin-induced nephrotoxicity and renal injury


Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Cellular Microenvironment ⓘ

pH↑, 1,  

Functional Outcomes ⓘ

GFR↑, 2,   toxicity↓, 1,   toxicity↝, 1,  
Total Targets: 4

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

HO-1↑, 1,   NRF2↑, 1,  

Cell Death ⓘ

p‑Akt↑, 1,   Casp3↓, 1,  

Migration ⓘ

mt-ATPase↑, 1,  

Barriers & Transport ⓘ

MRP↓, 1,  

Immune & Inflammatory Signaling ⓘ

IL6↓, 1,   NF-kB↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,  

Clinical Biomarkers ⓘ

creat↓, 1,   IL6↓, 1,  

Functional Outcomes ⓘ

GFR↑, 1,   RenoP↑, 1,  
Total Targets: 14

Scientific Paper Hit Count for: GFR, glomerular filtration rate
1 Bicarbonate(Sodium)
1 Propolis -bee glue
1 Thymoquinone
1 Curcumin
1 Cisplatin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1161  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

Home Page