ANXA7 Cancer Research Results

ANXA7, annexin A7: Click to Expand ⟱
Source:
Type:
NXA7 belongs to the annexin family of calcium-dependent phospholipid-binding proteins.
– It is involved in membrane trafficking, exocytosis, and cellular signal transduction.
– Its functions also extend to maintaining membrane integrity and participating in the regulation of intracellular calcium levels.

– Studies have shown that ANXA7 can function as a tumor suppressor in certain contexts, where its expression is reduced in tumors relative to normal tissue.
– In several tumor types, particularly prostate, breast, and glioblastoma, lower ANXA7 expression has been associated with a more aggressive tumor phenotype and poorer overall prognosis.
– Loss or reduced expression of ANXA7 may correlate with advanced disease stage, higher rates of recurrence, and decreased survival.
Scientific Papers found: Click to Expand⟱
1684- PBG,    Antitumor Activity of Chinese Propolis in Human Breast Cancer MCF-7 and MDA-MB-231 Cells
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231 - in-vitro, Nor, HUVECs
Apoptosis?, treatment of EECP for 24 and 48 h induced both cells apoptosis obviously
ANXA7↑, EECP significantly increased ANXA7 expression and ROS level, and NF-κB p65 level
ROS↑,
NF-kB↓, EECP significantly upregulated the expression of ANXA7 and downregulated NF-?B p65 level in a dose-dependent manner
MMP↓, mitochondrial membrane potential were depressed by EECP dramatically
selectivity↑, EECP had little or small cytotoxicity on normal human umbilical vein endothelial cells (HUVECs)

1685- PBG,    Antitumor Activity of Chinese Propolis in Human Breast Cancer MCF-7 and MDA-MB-231 Cells
- in-vitro, BC, MCF-7
ANXA7↑, Exposure to EECP significantly increased ANXA7 expression and ROS level
ROS↑,
NF-kB↓, NF-κB p65 level and mitochondrial membrane potential were depressed by EECP dramatically.
MMP↓,
selectivity↑, Interestingly, EECP had little or small cytotoxicity on normal human umbilical vein endothelial cells (HUVECs)
Dose⇅, propolis plays a dual role on ROS depending on concentrations: at high concentration, it exerts a prooxidant effect; at low concentration, it can also act as an antioxidant by scavenging free radicals.
ROS⇅,


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 2,   ROS⇅, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 2,  

Core Metabolism/Glycolysis ⓘ

ANXA7↑, 2,  

Cell Death ⓘ

Apoptosis?, 1,  

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 2,  

Drug Metabolism & Resistance ⓘ

Dose⇅, 1,   selectivity↑, 2,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: ANXA7, annexin A7
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1169  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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