selenoP Cancer Research Results

selenoP, selenoproteins: Click to Expand ⟱
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Selenoproteins are a group of proteins that incorporate the rare amino acid selenocysteine into their structure. Selenocysteine, sometimes called the “21st amino acid,” is encoded by the UGA codon in a unique context that requires specific translational machinery. Many selenoproteins are known for their antioxidant and redox-regulatory functions, which are critical in maintaining cellular homeostasis. These functions help protect cells from oxidative stress and damage—processes that, when dysregulated, can contribute to carcinogenesis.

Roles of Selenoproteins in Cancer.
1. Antioxidant Defense & Redox Regulation
-Glutathione Peroxidases (GPxs): Enzymes like GPX1, GPX2, and GPX3 reduce hydrogen peroxide and lipid hydroperoxides. This protects cells against oxidative DNA damage.
-Thioredoxin Reductases (TXNRDs): TXNRD1, TXNRD2, and TXNRD3 help maintain the reduced state of thioredoxin, thereby contributing to redox homeostasis and cell survival under stress.

2. Cellular Proliferation and Apoptosis -Selenoproteins may modulate signaling pathways that regulate cell cycle progression and apoptosis. Variations in expression levels—either upregulation or downregulation—can tip the balance toward uncontrolled cell growth or cell death.

The expression of selenoproteins in cancers is complex and can vary by tumor type. Here are some examples:

Glutathione Peroxidases (GPxs)
-GPX1: Both overexpression and underexpression have been reported depending on the tumor context. In some cases, high GPX1 expression can help cancer cells survive oxidative stress.
-GPX2: Often upregulated in colorectal cancer and some GC, poor prognosis.
-GPX3: Typically downregulated in many cancers with tumor progression and poor outcome, suggesting its role as a tumor suppressor.

Thioredoxin Reductases (TXNRDs)
-TXNRD1: Frequently overexpressed in various tumors such as lung, breast, and liver cancers.
High TXNRD1 levels are generally associated with a poor prognosis.
-SELENOP (Selenoprotein P) SELENOP serves as a selenium transport protein and has antioxidant properties. Decreased SELENOP expression has been linked to poorer outcomes in some cancers, possibly due to reduced selenium availability for other protective selenoproteins.

Other Selenoproteins
-SELENOF and SELENOS:
-SELENOM and SELENOK:
Scientific Papers found: Click to Expand⟱
4485- Se,    Selenium stimulates the antitumour immunity: Insights to future research
- Review, NA, NA
*antiOx↑, At nutritional low doses, selenium, depending on its form, may act as an antioxidant, protecting against oxidative stress, supporting cell survival and growth, thus, plays a chemo-preventive role
chemoPv↑,
ROS↑, at supra-nutritional higher pharmacological doses, selenium acts as pro-oxidant inducing redox signalling and cell death
Imm↑, selenium stimulates the immune system against cancer
selenoP↑, anti-oxidant through selenoproteins
*IL2↑, consumption of Se-enriched foods (200 μg per serving for 3 days) increases the levels of interleukin IL-2, IL-4, IL-5, IL-13 and IL-22, indicating an activated Th2-type response
*IL4↑,
*TNF-α↓, taking selenised yeast (300 μg.day−1) downregulates the gene expression of tumour necrosis factor (TNF)α and transforming growth factor (TGF)β; thus, consequently inhibit the epithelial-to-mesenchymal transition (EMT) in non-malignant prostate tissue
*TGF-β↓,
*EMT↓,
Risk↓, immune-enhancing effects of Se may reduce the risk of cancer
*GPx↑, chemo-preventive effects of Se are mainly mediated by the anti-oxidant function of selenoenzymes such as GPxs and TXNRDs [68] because Se supplementation increases both GPx1 and GPx4 activity in humans
*TrxR↑,

4492- Se,    Selenium in cancer prevention: a review of the evidence and mechanism of action
- Review, Var, NA
Risk↓, Since as early as the 1960s geographical studies have shown a consistent trend for populations with low Se intakes to have higher cancer mortality rates
AntiCan↑, Interventions with Sehave shown benefit in reducing the risk of cancer incidence and mortality in all cancers combined, and specifically in liver, prostate, colo-rectal and lung cancers.
*selenoP↑, data showing an effect of selenoprotein genotype on cancer risk implies that selenoproteins are indeed implicated
TumMeta↓, There is some evidence that Se may affect not only cancer risk but also progression and metastasis.
*DNAdam↓, Supplementation of the diet of sexually-intact elderly male dogs with Se, as selenomethionine or high-Se yeast, at 3 or 6 ug/kg body weight per d for 7 months was found to reduce DNA damage and up-regulate epithelial cell apoptosis in their prostate
OS↑, significant secondary end-point effects of 50% lower total cancer mortality and 37% lower total cancer incidence were found, with fewer prostate, colo–rectal and lung cancers(200 ug Se (as Se-enriched yeast)/d
*ROS↓, ability of Se in selenoproteins to reduce oxidative stress is relevant to its anti-cancer effects.

4613- Se,  Rad,    Effect of Selenium and Selenoproteins on Radiation Resistance
- Review, Nor, NA
*selenoP↑, GPX1 is a selenoprotein with an active site containing selenocysteine
*GPx1↑,
*GPx4↑, GPX4 effectively inhibits lipid peroxide, it also promotes DNA repair
*lipid-P↓,
*DNAdam↓,
*ROS↓, It has been reported that selenium and selenoproteins can scavenge ROS directly.
*radioP↑, selenium and selenium protein as radiation protective agents to alleviate multiple organ damage caused by radiation or treat related diseases.

4724- Se,    Chapter Four - Selenium in the Redox Regulation of the Nrf2 and the Wnt Pathway
- Review, Var, NA
Risk↓, Selenium deficiency is known to increase cancer risk by so far unclear mechanisms.
*selenoP↑, Selenium exerts its biological effects via selenocysteine as an integral part of selenoproteins.
other↝, A moderate Se deficiency activates the Nrf2 and the Wnt pathways
Risk↓, not only healthy cells but also malignant ones benefit from intact Keap1/Nrf2 signaling, making a dysregulated hydroperoxide signaling a plausible explanation for the increased cancer risk in selenium deficiency.

4717- Se,    A systematic review of Selenium as a complementary treatment in cancer patients
- Review, Var, NA
*antiOx↑, Selenium, a trace element with antioxidant properties, has been widely studied for its benefits in cancer treatment.
eff↝, clear statement regarding the effectiveness of Se supplementation is not possible
radioP↑, whereas cancer patients with a Se deficiency could profit from a Se supplementation during radio- or chemotherapy.
chemoP↑,
*selenoP↑, Se is crucial for the biosynthesis of selenoproteins and essential enzymes (glutathione peroxidases (GSH-PPX), thioredoxin reductase, and selenoprotein P
*GPx↑,
TrxR↑,
*ROS↓, Glutathione peroxidase, an enzyme within this group, directly neutralizes reactive oxygen species, which can be detrimental to cells.

4712- Se,    Selenium and selenoproteins: key regulators of ferroptosis and therapeutic targets in cancer
- Review, Var, NA
selenoP↑, Selenium (Se) and selenoproteins regulate ferroptosis, a lipid peroxidation–driven form of cell death
Ferroptosis↑,
lipid-P↑,

4721- SeNPs,    A review on selenium nanoparticles and their biomedical applications
- Review, AD, NA - Review, Diabetic, NA - Review, Arthritis, NA
*antiOx↑, SeNPs have attractive antioxidant and anti-inflammatory properties
*Inflam↓,
*eff↝, SeNPs-based drug delivery in Alzheimer, diabetes, infectious disease, Rheumatoid arthritis, and cancer is being investigated.
*selenoP↑, Selenium is incorporated into Selenoproteins such as selenocysteine (Sec)
*Bacteria↓, efficacy against various cancer cells, microbial pathogens, viral infections, neuroprotective properties, diabetic control, oxidative stress, and inflammation-mediated illnesses such as rheumatoid arthritis.
*neuroP↑,
*ROS↓,
ChemoSen↑, Selenium nanoparticles (SeNPs) have been utilized with drugs like 5-Fluorouracil (5-FU) and irinotecan, displaying enhanced anticancer activity.

4719- SeNPs,    Selenium nanoparticles are more efficient than sodium selenite in producing reactive oxygen species and hyper-accumulation of selenium nanoparticles in cancer cells generates potent therapeutic effects
- in-vivo, Var, NA
ROS↑, ROS production by SeNPs in above systems is more efficient than by selenite.
selenoP↑, (SeNPs) administered via oral route possess similar capacities of increasing selenoenzyme activities as the extensively examined sodium selenite, selenomethionine and methylselenocysteine, and yet display the lowest toxicity among these selenium comp
*toxicity↓,

4605- SeNPs,    Selenium nanoparticles: An insight on its Pro-oxidant andantioxidant properties
- Review, NA, NA
*antiOx↑, unique antioxidant properties
*selenoP↑, antioxidant effect is chiefly due to the selenoenzymes such as thioredoxin reductase (TR) and glutathione peroxidasefamily (GPxs) which is having ROS scavenging activity.
*Dose↝, In humans, Se has the narrowest margin levels ranges between dietary deficiency (<40mg/day) and toxic levels (>400mg/day).
*toxicity↓, selenium having a narrow therapeutic window and the toxicity margins while, the selenium nanoparticle (SeNPs) having unusually reduced toxicity.
ROS↑, Because of the acidic pH state with redox imbalance these malignant cells will enables the selenium nanoparticles to exhibits pro-oxidant effect
ER Stress↑, cause mitochondrial membrane disruption which can cause leakageof mitochondrial (Mt) proteins and also causes endoplasmic reticulum(ER) stress.

4609- SeNPs,    Physiological Benefits of Novel Selenium Delivery via Nanoparticles
- Review, Var, NA - Review, IBD, NA - Review, Diabetic, NA
*selenoP↑, Biologically, Se is incorporated primarily into selenoproteins as the selenomethionine and selenocysteine amino acids at active sites
Risk↓, Se deficiency and high Se status is coincident with a range of pathologies, including obesity [10,11], cancer [12,13], arthropathy [14] as well as several immune- and neurological-related disorders
AntiCan↑, There is a growing body of research with a focus on the role of Se in cancer prevention which indicates a link between high Se exposure and decreased risk of breast, oesophagus, and prostate cancers
ROS↑, selenite treatment stimulated cancer cell apoptosis via a mechanism involving enhanced ROS generation and the accumulation of hydrogen peroxide which, ultimately, decreased cell viability
*Dose↝, IBD patients had lower Se levels than that of healthy individuals, potentially illustrating the importance of dietary Se as an antioxidant/micronutrient in the pathogenesis of IBD in humans
*toxicity↓, A major benefit of SeNPs is the significantly lower toxicity while retaining similar physiological impacts and efficacy in enhancing selenoprotein activities in comparison to that of other chemical seleno-forms
*BioAv↑, Selenium nanoparticles show an enhanced uptake post-ingestion as these SeNPs are smaller in size with larger surface areas and are more permeable through capillary walls, leading to superior epithelial cell uptake and enhanced bioactivity.
*GutMicro↑, research has also show that dietary Se improved the gut microbiome favourably by enhancing the abundance of beneficial bacteria and limiting the growth of undesirable pathogens
*other↓, In diabetic rats, SeNPs have shown to reduce proinflammatory markers, including IL-1β and TNF levels and renal MDA levels leading to lower oxidative stress, indicated by improved renal functions due to lower serum urea and creatinine along with reduc

4608- SeNPs,    Selenium Nanoparticles for Biomedical Applications: From Development and Characterization to Therapeutics
- Review, Var, NA - NA, AD, NA
*toxicity↝, Although Se shows several beneficial properties in human health, it has also a narrow therapeutic window, and therefore the excessive intake of inorganic and organic Se-based compounds often leads to toxicity
*toxicity↓, Nanoparticles based on Se (SeNPs) are less toxic than inorganic and organic Se.
*other↝, The twenty-first amino acid, selenocysteine (Sec),[4] is used to produce selenoproteins, whose function often depends on the presence of Se in their active site,[5] such as reactive oxygen species (ROS) protection.
ROS↑, SeNPs led to the production of higher levels of ROS than those obtained following the treatment of cancer cells with selenite, therefore presenting better antitumor properties than the Se salts
*Dose↝, recommended daily allowance (RDA) is 60 µg/day for women, 70 µg d−1 for men,[3] 75 µg d−1 for lactating women, and 65 µg d−1 for pregnant women according to the European Food Safety Authority
*selenoP↑, Se is mostly used for the production of selenoproteins, which are essential to human health due to their antioxidant effect, and role in controlling thyroid hormone metabolism, protein folding, redox signaling, among other functions.
AntiCan↑, Se has demonstrated antitumor, antiviral, antibacterial, and antifungal properties,[3] decreasing the risk of tuberculosis in HIV infected patients,[7, 47] and is well correlated to cancer prevention.
AntiTum↑,
*Bacteria↓,
*radioP↑, Se has shown to protect against heavy metals and radiation toxicity
*BioAv↑, food processing can also influence Se bioavailability, since increased temperatures improve protein digestibility, and enhance Se release and bioavailability
*Inflam↓, Se has anti-inflammatory and immunomodulatory actions
*Imm↑,
ChemoSen↑, Se has also been studied for cancer treatment as a radiotherapy and chemotherapeutic adjuvant since malignant cells are more susceptible to Se pro-oxidant effects than healthy cells.
*AntiAg↑, potential role of Se and selenoproteins in protecting the cardiovascular system against oxidative damage and excessive platelet aggregation
selectivity↑, SeNPs have shown potential to target specific cancer cells, by passive targeting based on the fact that the tumor environment is more acidic than the environment existing in healthy tissues
eff↑, chitosan(h)–SeNPs presented higher cellular uptake by cancer cells lines than normal cell lines, probably due to the higher amount of -NH3+ groups, which permits an enhanced electrostatic attraction between the positively charged chitosan(h)–SeNPs
other↝, In general, the charge of SeNPs is negative,[37, 138, 121] however surface modification with positive charged compounds such as chitosan can also flip the charge of SeNPs to positive
*eff↑, SeNPs have also shown to have a synergistic effect when combined with metformin
*Aβ↓, SeNPs have been shown to reduce Aβ aggregation and induce their disaggregation, in addition to acting as an antioxidant in the brain, either directly or by being part of GPx
*eff↑, SeNPs have also been studied together with other compounds that also shown properties against Alzheimer's disease, such as resveratrol (Res),[188] curcumin (Cur),[184] chiral D-penicillamine (DPen),[167] and chlorogenic acid (CGA)

4491- SeNPs,  Chit,  VitC,    Synthesis of a Bioactive Composition of Chitosan–Selenium Nanoparticles
- Study, NA, NA
*ROS↓, chitosan-selenium nanoparticles has a corrective effect on the oxidative processes of the body, reducing the activity of free-radical oxidation in the blood of animals
*selenoP↑, Selenium is included in selenoproteins, which have a wide range of biological effects, including antioxidant and anti-inflammatory effects.
*antiOx↑,
*Inflam↓,
*Risk↓, The lack of selenium in the body is a risk factor for the development of various pathologies.
*toxicity↓, Compared to organic and inorganic forms of selenium, selenium nanoparticles (NPs) exhibit lower toxicity and superior antioxidant, immunomodulatory, bactericidal, and antitumor activity
AntiTum↑,
Dose↝, NPs with sizes of 2–3 nm (33.4 wt %) and ~ 37 nm (66.6 wt %) are formed.

4503- SeNPs,    Prophylactic supplementation with biogenic selenium nanoparticles mitigated intestinal barrier oxidative damage through suppressing epithelial-immune crosstalk with gut-on-a-chip
- in-vitro, Nor, NA
*selenoP↑, further metabolized into selenocystine and trace amounts of selenite within cells, which are then incorporated into the synthesis of antioxidant selenoenzymes.
*ROS↓, antioxidant selenoenzyme activities, modulated AMPK/NLRP3/Nrf2 pathways, effectively alleviated oxidative stress, maintained mitochondrial homeostasis, inhibited pro-inflammatory factors expression.
*Inflam↓,
*other↝, eventually exhibit an effective protective effect against intestinal barrier oxidative damage.

4441- SeNPs,    The Role of Selenium Nanoparticles in the Treatment of Liver Pathologies of Various Natures
- Review, Nor, NA
*ROS↓, liver is the depot for most selenoproteins, which can reduce oxidative stress, inhibit tumor growth, and prevent other liver damage.
*hepatoP↑, their hepatoprotective properties
*selenoP↑,
*ALAT↓, (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (AP). However, the introduction of SeNPs significantly reduced the change in the level of these enzymes
*AST↓,
*GSH↑, significant increase in the content of glutathione and glutathione peroxidase in the liver
*GPx↑,
*TNF-α↓, In addition, the expression level of TNF-α, IL-6, NF-kB, and p65 genes was significantly increased in the cadmium-treated group (compared with the control), co-treatment of SeNPs and lacto-SeNPs led to a decrease in the expression of these genes.
*IL6↓,
*NF-kB↓,
*p65↓,
*Dose⇅, lactobacilli were used to restore Se from sodium selenite, while the synthesized nanoparticles had a size of 42.4 ± 10.5 nm and a zeta potential of −36.6 mV.

4457- SeNPs,    Selenium nanoparticles: a review on synthesis and biomedical applications
- Review, Var, NA - NA, Diabetic, NA
*BioAv↑, Recently, selenium nanoparticles (SeNPs) attracted the interest of many researchers due to their biocompatibility, bioavailability, and low toxicity.
*toxicity↓,
*eff↑, synthesized SeNPs demonstrate greater compatibility with human organs and tissues
chemoPv↑, They can also act as chemopreventive agents, anti-inflammatory agents, and antioxidants.
*Inflam↓,
antiOx↑,
*selenoP↑, Selenium, a part of selenoproteins and selenocompounds within the human body, plays a critical role in reproduction, DNA synthesis, thyroid hormone, metabolism, and protection from infections and oxidative damage.
*ROS↓, also figure 6
*Dose↝, The United Kingdom group of vitamins and minerals recommended the daily intake of selenium by women and men should be 60 μg and 70 μg, respectively.3 A daily intake of more than 400 μg could be toxic
AntiCan↑, Several studies have supported their anticancer,22 antioxidant,21 antimicrobial,23–25 and anti-biofilm properties
*Bacteria↓,
eff↑, Tran et al.65 reduced sodium selenite by ascorbic acid using polyvinyl alcohol (PVA) as the stabilising agent, resulting in an average particle size of 70 nm . The absorption was observed in the wavelength range 250 to 450 nm
DNAdam↑, figure 6
selectivity↑, figure 6
*eff↑, At a concentration of 2.0 mg kg−1 body weight, chitosan stabilized SeNPs resulted in improved antidiabetic activity.

4739- SSE,  Chemo,  Rad,    Therapeutic Benefits of Selenium in Hematological Malignancies
- Review, Var, NA
ChemoSen↑, Supplementing chemotherapy and radiotherapy with selenium has been shown to have benefits against various cancers.
radioP↑,
QoL↑, This approach has also been shown to alleviate the side effects associated with standard cancer therapies and improve the quality of life in patients.
Risk↓, selenium levels in patients have been correlated with various cancers
*selenoP↑, Selenium is present in all mammals and is utilized by selenoproteins
TumCP↓, It has been reported that Se possesses anti-proliferative, anti-inflammatory, and anti-viral activities in addition to immune altering properties and has been implicated in various cancers
Inflam↓,
ChemoSen↑, Selenium-based compounds exhibit chemopreventive or chemotherapeutic properties through regulation of various processes such as cell cycle arrest, apoptosis, angiogenesis, etc.
TumCCA↑,
Apoptosis↑,
angioG↓,
Dose⇅, The amount of the selenium agent administered can influence whether prooxidant or antioxidant activity is observed.
ROS↑, Selenium-based compounds have been shown to exhibit chemopreventive and anticancer properties through prooxidant activities and the regulation of cellular redox homeostasis by altering thiol groups in multiple metabolic pathways, stimulating the prod
eff↑, The potency of selenium in an in vitro model of lung adenocarcinoma was increased with the addition of fish oil
Risk↓, In clinical trials, it has been observed that selenium and vitamin C supplementation decrease the incidence and mortality of gastric and lung cancer
eff∅, A selenium supplementation did not negatively impact the efficacy of chemotherapy
CSCs↓, Selenium Is Potent in Leukemia Stem Cells through In Vitro and In Vivo AML/CML Models
ROS↑, higher intracellular oxidative stress (or levels of ROS) in chronic or acute myeloid leukemia stem cells

4740- SSE,    Optimising Selenium for Modulation of Cancer Treatments
- Review, Var, NA
*selenoP↑, Selenium is an essential trace element involved in many biological processes that are mediated through, at least, 25 selenoproteins expressed in humans.
*Dose↓, 50-200 μg/day have been used mainly for primary prevention (15), and Se supplementation at these doses for Se-deplete individuals has been associated with lower overall mortality and incidence of certain cancer types
Risk↓,
*toxicity↝, Animal laboratory studies have shown that the organic forms of Se are both more effective and safer than the commonly-used inorganic forms such as sodium selenite (SS), which are more genotoxic
Dose↑, All patients given 4,800 μg SLM twice daily achieved plasma Se levels >15 μM, the Se concentration required for reduced chemotherapy-induced toxicity and enhanced antitumor efficacy of chemotherapeutic drugs in preclinical animal models
chemoP↑, hence the optimal form and dose of Se to be used with chemotherapy or radiotherapy remains unclear.
radioP↑,

4733- SSE,    Selenium supplementation of lung epithelial cells enhances nuclear factor E2-related factor 2 (Nrf2) activation following thioredoxin reductase inhibition
- NA, Nor, NA
*selenoP↑, Se is required for the synthesis and function of selenoenzymes including thioredoxin (Trx) reductase-1 (TXNRD1) and glutathione peroxidases (GPx).
*Trx↑,
*GPx↑, TXNRD1 and GPX2 protein expression and enzymatic activity were significantly greater upon Se supplementation
*NRF2↑, Se levels positively influence Nrf2 activation and selenoenzyme responses following TXNRD1 inhibition.

4610- SSE,  Rad,    Protection during radiotherapy: selenium
- Review, Var, NA
*radioP↑, Ebselen, and sodium selenite, emerges as a promising radioprotective agent with demonstrated efficacy across diverse radiation-injured organs, highlighting its significance as an effective and potent antioxidant that affordable for most patients.
*antiOx↑,
*Inflam↓, In short, the antioxidation, anti-inflammatory effect and DNA stabilizing formed the protective effects of selenium against DNA damage induced by radiation
*DNAdam↓,
*lipid-P↓, Se-Met could efficiently inhibit the formation of lipid peroxy radicals, preventing lipid peroxidation
*selenoP↑, primarily enhance the expression of selenoproteins, thus sodium selenite may not be inherently antioxidant until incorporated into selenoproteins with oxidoreductase functions
*GPx1↑, sodium selenite could increase GPx-1 activity in a dose- and time-dependent manner
*BUN↓, 100 µg/day of selenium in the form of sodium selenite or Se-L-Met, blood urea nitrogen (BUN) level of rats significantly decreased.

4498- SSE,    Selenium in Human Health and Gut Microflora: Bioavailability of Selenocompounds and Relationship With Diseases
- Review, Var, NA - Review, AD, NA - Review, IBD, NA
*Imm↑, Selenium is essential for the maintenance of the immune system, conversion of thyroid hormones, protection against the harmful action of heavy metals and xenobiotics as well as for the reduction of the risk of chronic diseases
*GutMicro↑, Selenium is able to balance the microbial flora avoiding health damage associated with dysbiosis.
*BioAv↑, highlighting their role in improving the bioavailability of selenocompounds
*Risk↓, Selenium deficiency may result in a phenotype of gut microbiota that is more susceptible to cancer, thyroid dysfunctions, inflammatory bowel disease, and cardiovascular disorders.
*Dose↝, highest sources of Se with concentrations that range from 1.80 to 320.80 μg Se/g
Risk↓, serum Se greater than or equal to 135 μg/L were associated with reduced cancer mortality
*CRP↓, Se supplementation decreases the serum levels of C-reactive protein and increases the levels of GPX, suggesting a positive effect on reduction of inflammation and oxidative stress in cardiovascular diseases
*GPx↓,
*Inflam↓,
*selenoP↑, SELENOP may be involved in some brain disorders, in particular in Alzheimer's disease, providing Se for brain tissue to produce selenoproteins.
*Dose↝, 100, 200, or 300 μg Se/day as Se-enriched yeast or placebo yeast. The results of this study warn that a 300-μg/day dose of Se (as Se yeast) taken for 5 years in a country with moderately low Se status can increase all-cause mortality by 10 years late
*ROS↓, Animals treated with SeCys and selenocystine showed a reduction in the concentration of ROS and malondialdehyde (MDA), as well as an increase in intestinal activity of SOD and GPX, which seems to indicate a protective effect against damage to the gut
*MDA↓,
*SOD↑,
*GPx↑,
*IL1↓, In addition, the levels of IL-1, MCP, IL-6, and TNF-α were significantly reduced in the group treated with SeCys
*MCP1↓,
*IL6↓,
*TNF-α↓,
Risk↓, higher SELENOP concentrations were inversely associated with colorectal cancer risk
*neuroP↑, Due to the antioxidant property of Se, some selenoproteins play a neuroprotective role
*memory↑, Long-term dietary supplementation (3 months) with Se-enriched yeast (Se-yeast) in triple transgenic mouse model of Alzheimer disease (AD), significantly improved spatial learning, retention of neuronal memory and activity

4497- SSE,    Selenium and inflammatory bowel disease
- Review, Var, NA - Review, IBD, NA
*GutMicro↑, restoring gut homeostasis . gut microbiota is also altered by selenium deficiency.
*selenoP↑, selenoproteins that mediate gastrointestinal inflammation
*Inflam↓, crucial role for long-term (∼8 wk or more) selenium supplementation in suppressing gastrointestinal inflammation-based tissue damage,
Risk↓, SePP1 levels are inversely associated with the development of IBD and colorectal cancer
*NF-kB↓, ability of selenium to downregulate nuclear factor-κB (NF-κB)-dependent pathways
*ROS↓, reduce reactive oxygen specie

4494- SSE,    Advances in the study of selenium and human intestinal bacteria
- Review, IBD, NA - Review, Var, NA
*Risk↓, experts from Penn State University found that selenium levels in within individuals were strongly associated with the development of inflammatory bowel disease, and that lower selenium levels were associated with greater susceptibility to inflammator
OS↑, A study of more than 13,000 followers over 12 years found that serum Se levels ≥135 μg/L was associated with reduced cancer mortality
*CRP↓, selenium supplementation was found to reduce serum C-reactive protein levels and increase GPX levels, suggesting a positive effect of selenium on reducing inflammation and oxidative stress in cardiovascular disease
*GPx↑,
*Inflam↓,
*ROS↓,
*GutMicro↑, adequate or high levels of Se diet may optimize the intestinal microflora to prevent intestinal dysfunction and chronic diseases
*selenoP↑, Selenium intake in food also affects the selenium status and expression of selenoproteins in the host.
*other↓, Selenium deficiency is common in IBD patients, up to 30.9%

4614- SSE,  Rad,    Updates on clinical studies of selenium supplementation in radiotherapy
- Review, Nor, NA
*toxicity∅, At the dose of selenium used in these studies (200–500 μg/day), selenium supplementation did not reduce the effectiveness of radiotherapy, and no toxicities were reported.
Risk↓, moderate deficiency of selenium has been linked to many conditions, such as an increased risk of cancer, infections and male infertility;
*selenoP↑, Selenium in selenoproteins can reduce oxidative damage and can limit DNA damage
*ROS↓,
*DNAdam↓,
*QoL↑, Most of the studies revealed positive effects of selenium supplementation on the general condition of the patients and their quality of life.
*radioP↑, prevented or reduced the side effects of radiotherapy and did not reduce the effectiveness of radiotherapy or cause any toxicity.
*Dose↝, sodium selenite at doses ranging from 200–500 μg daily by oral administration may offer benefits for head and neck cancer; head and neck cancer with lymphedema; and oral, cervical and uterine cancer patients who undergo radiotherapy and have low sele


Showing Research Papers: 1 to 23 of 23

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 23

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Ferroptosis↑, 1,   lipid-P↑, 1,   ROS↑, 7,   selenoP↑, 3,   TrxR↑, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   Ferroptosis↑, 1,  

Transcription & Epigenetics ⓘ

other↝, 2,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 1,  

Migration ⓘ

TumCP↓, 1,   TumMeta↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,  

Immune & Inflammatory Signaling ⓘ

Imm↑, 1,   Inflam↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 4,   Dose↑, 1,   Dose⇅, 1,   Dose↝, 1,   eff↑, 3,   eff↝, 1,   eff∅, 1,   selectivity↑, 2,  

Functional Outcomes ⓘ

AntiCan↑, 4,   AntiTum↑, 2,   chemoP↑, 2,   chemoPv↑, 2,   OS↑, 2,   QoL↑, 1,   radioP↑, 3,   Risk↓, 12,  
Total Targets: 34

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 6,   GPx↓, 1,   GPx↑, 6,   GPx1↑, 2,   GPx4↑, 1,   GSH↑, 1,   lipid-P↓, 2,   MDA↓, 1,   NRF2↑, 1,   ROS↓, 12,   selenoP↑, 20,   SOD↑, 1,   Trx↑, 1,   TrxR↑, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1,   BUN↓, 1,  

Transcription & Epigenetics ⓘ

other↓, 2,   other↝, 2,  

DNA Damage & Repair ⓘ

DNAdam↓, 4,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,  

Migration ⓘ

AntiAg↑, 1,   TGF-β↓, 1,  

Immune & Inflammatory Signaling ⓘ

CRP↓, 2,   IL1↓, 1,   IL2↑, 1,   IL4↑, 1,   IL6↓, 2,   Imm↑, 2,   Inflam↓, 9,   MCP1↓, 1,   NF-kB↓, 2,   p65↓, 1,   TNF-α↓, 3,  

Protein Aggregation ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 4,   Dose↓, 1,   Dose⇅, 1,   Dose↝, 7,   eff↑, 4,   eff↝, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   AST↓, 1,   CRP↓, 2,   GutMicro↑, 4,   IL6↓, 2,  

Functional Outcomes ⓘ

hepatoP↑, 1,   memory↑, 1,   neuroP↑, 2,   QoL↑, 1,   radioP↑, 4,   Risk↓, 3,   toxicity↓, 6,   toxicity↝, 2,   toxicity∅, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 3,  
Total Targets: 55

Scientific Paper Hit Count for: selenoP, selenoproteins
9 Selenium NanoParticles
8 Selenite (Sodium)
6 Selenium
4 Radiotherapy/Radiation
1 chitosan
1 Vitamin C (Ascorbic Acid)
1 Chemotherapy
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1172  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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