FOXO4 Cancer Research Results

FOXO4, Forkhead box O 4: Click to Expand ⟱
Source:
Type:
FOXO4 is a member of the Forkhead box O (FOXO) family of transcription factors that play key roles in regulating numerous cellular processes, including cell cycle progression, apoptosis, DNA repair, oxidative stress resistance, and cellular senescence.
-Under normal conditions, FOXO4 contributes to tumor suppression by inducing cell cycle arrest and apoptosis, thereby limiting malignant transformation.
-Its activity is often inhibited in various cancers, either through post-translational modifications (e.g., phosphorylation by oncogenic kinases such as AKT) or altered expression, which can contribute to cancer progression.
Scientific Papers found: Click to Expand⟱
7854- isoO,    Isoorientin induces apoptosis through mitochondrial dysfunction and inhibition of PI3K/Akt signaling pathway in HepG2 cancer cells
- in-vitro, Liver, HepG2
TumCD↑, selectivity↑, *toxicity↓, cl‑PARP↑, DNAdam↑, Bax:Bcl2↑, MMP↓, Cyt‑c↑, Casp3↑, ROS↑, NO↑, p‑Akt↓, FOXO4↑, eff↓,
1744- RosA,    Therapeutic Applications of Rosmarinic Acid in Cancer-Chemotherapy-Associated Resistance and Toxicity
- Review, Var, NA
chemoR↓, ChemoSideEff↓, RadioS↑, ROS↓, ChemoSen↑, BioAv↑, Half-Life↝, antiOx↑, ROS↑, Fenton↑, DNAdam↑, Apoptosis↑, CSCs↓, HH↓, Bax:Bcl2↑, MDR1↓, P-gp/ABCB1↓, eff↑, eff↑, FOXO4↑, *eff↑, *ROS↓, *JNK↓, *ERK↓, *GSH↑, *H2O2↑, *MDA↓, *SOD↑, *HO-1↑, *CardioT↓, selectivity↑,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Fenton↑, 1,   ROS↓, 1,   ROS↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 1,  

Cell Death(tgid=5) ⓘ

p‑Akt↓, 1,   Apoptosis↑, 1,   Bax:Bcl2↑, 2,   Casp3↑, 1,   Cyt‑c↑, 1,   TumCD↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 2,   cl‑PARP↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs↓, 1,   FOXO4↑, 2,   HH↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↑, 1,  

Barriers & Transport(tgid=15) ⓘ

P-gp/ABCB1↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   chemoR↓, 1,   ChemoSen↑, 1,   eff↓, 1,   eff↑, 2,   Half-Life↝, 1,   MDR1↓, 1,   RadioS↑, 1,   selectivity↑, 2,  

Functional Outcomes(tgid=23) ⓘ

ChemoSideEff↓, 1,  
Total Targets: 28

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

GSH↑, 1,   H2O2↑, 1,   HO-1↑, 1,   MDA↓, 1,   ROS↓, 1,   SOD↑, 1,  

Cell Death(tgid=5) ⓘ

JNK↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↑, 1,  

Functional Outcomes(tgid=23) ⓘ

CardioT↓, 1,   toxicity↓, 1,  
Total Targets: 11

Scientific Paper Hit Count for: FOXO4, Forkhead box O 4
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1177  State#:%  Dir#:2
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