FOXO4 Cancer Research Results

FOXO4, Forkhead box O 4: Click to Expand ⟱
Source:
Type:
FOXO4 is a member of the Forkhead box O (FOXO) family of transcription factors that play key roles in regulating numerous cellular processes, including cell cycle progression, apoptosis, DNA repair, oxidative stress resistance, and cellular senescence.
-Under normal conditions, FOXO4 contributes to tumor suppression by inducing cell cycle arrest and apoptosis, thereby limiting malignant transformation.
-Its activity is often inhibited in various cancers, either through post-translational modifications (e.g., phosphorylation by oncogenic kinases such as AKT) or altered expression, which can contribute to cancer progression.
Scientific Papers found: Click to Expand⟱
1744- RosA,    Therapeutic Applications of Rosmarinic Acid in Cancer-Chemotherapy-Associated Resistance and Toxicity
- Review, Var, NA
chemoR↓, ChemoSideEff↓, RadioS↑, ROS↓, ChemoSen↑, BioAv↑, Half-Life↝, antiOx↑, ROS↑, Fenton↑, DNAdam↑, Apoptosis↑, CSCs↓, HH↓, Bax:Bcl2↑, MDR1↓, P-gp↓, eff↑, eff↑, FOXO4↑, *eff↑, *ROS↓, *JNK↓, *ERK↓, *GSH↑, *H2O2↑, *MDA↓, *SOD↑, *HO-1↑, *CardioT↓, selectivity↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Fenton↑, 1,   ROS↓, 1,   ROS↑, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   Bax:Bcl2↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 1,   FOXO4↑, 1,   HH↓, 1,  

Barriers & Transport ⓘ

P-gp↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   chemoR↓, 1,   ChemoSen↑, 1,   eff↑, 2,   Half-Life↝, 1,   MDR1↓, 1,   RadioS↑, 1,   selectivity↑, 1,  

Functional Outcomes ⓘ

ChemoSideEff↓, 1,  
Total Targets: 20

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

GSH↑, 1,   H2O2↑, 1,   HO-1↑, 1,   MDA↓, 1,   ROS↓, 1,   SOD↑, 1,  

Cell Death ⓘ

JNK↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,  

Functional Outcomes ⓘ

CardioT↓, 1,  
Total Targets: 10

Scientific Paper Hit Count for: FOXO4, Forkhead box O 4
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1177  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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