Piezo1 Cancer Research Results

Piezo1, Piezo1: Click to Expand ⟱
Source:
Type:
Piezo1 is a mechanosensitive ion channel that converts mechanical stimuli into electrochemical signals.

Piezo1 protein is a mechanosensitive ion channel that allows intracellular calcium influx in response to various mechanical signals such as static pressure, shear stress, and membrane stretch and further initiates downstream biological responses. It is critical in various physiological processes, including the development of vasculatures, regulation of red blood cell volume, and sensation of light touch. Piezo1 is also highly expressed in the bone, regulating the differentiation of mesenchymal stem cells and mediating calcium ion influx in osteocytes and osteoblasts.

In a number of cancer types (such as breast, colon, and prostate cancer), studies have found that Piezo1 is often upregulated.
An increase in Piezo1 expression can promote enhanced cell migration and invasive behavior, both of which are critical for cancer spread.
Scientific Papers found: Click to Expand⟱
1755- WBV,    Reduction of breast cancer extravasation via vibration activated osteocyte regulation
Dose∅, However, intense exercise is physically challenging for bedridden, disabled, or aged patients. As an exercise surrogate, low-magnitude (<1 g) high-frequency (>30 Hz) (LMHF) vibration has gained growing interest
TumMeta↑, These data indicated that LMHF vibration could inhibit cancer extravasation, suggesting that vibration may suppress bone metastasis in breast cancer patients.
eff∅, Nevertheless, recent clinical studies indicated that LMHF vibration had minimum or no beneficial effects for the elderly (>65 years old)
Piezo1↑, LMHF vibration (60 Hz, 0.3 g, 1 h, Figure 1) significantly up-regulated the expressions of Piezo1 (1.63-fold) and COX-2 (1.32-fold) and down-regulated the expression of RANKL (0.86-fold).
COX2↑,
RANKL↓, down-regulated the expression of RANKL (0.86-fold).
TumCG∅, Vibration (60 Hz, 0.3 g, 1 h/day for 3 days) did not significantly impact cell growth and viability
tumCV∅,
TumCI↓, Vibration reduced breast cancer invasion via direct and indirect osteocyte signaling. vibration decreased cancer invasion distance by 24%


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Transcription & Epigenetics ⓘ

tumCV∅, 1,  

Proliferation, Differentiation & Cell State ⓘ

Piezo1↑, 1,   TumCG∅, 1,  

Migration ⓘ

TumCI↓, 1,   TumMeta↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↑, 1,  

Hormonal & Nuclear Receptors ⓘ

RANKL↓, 1,  

Drug Metabolism & Resistance ⓘ

Dose∅, 1,   eff∅, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Piezo1, Piezo1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1182  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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