KISS1 Cancer Research Results

KISS1, KISS1: Click to Expand ⟱
Source:
Type:
Kiss1 is widely recognized as a metastasis suppressor in several cancers. Kiss1 serves as an important metastasis suppressor gene whose expression is generally linked to a less aggressive clinical course in cancers such as breast cancer and melanoma.
Scientific Papers found: Click to Expand⟱
6546- BSB,    α-Bisabolol Inhibits Invasiveness and Motility in Pancreatic Cancer Through KISS1R Activation
- in-vitro, PC, NA
Apoptosis↑, α-Bisabolol is a plant-derived, oily sesquiterpene alcohol that induces apoptosis of various cancer cells.
TumCI↓, In this study, demonstrated that α-bisabolol suppressed the invasiveness and motility of a pancreatic cancer cell line.
KISS1↑, Polymerase chain reaction analysis revealed that α-bisabolol induced Kisspeptin 1 receptor (KISS1R) in pancreatic cancer cell lines.

1776- MEL,    Therapeutic strategies of melatonin in cancer patients: a systematic review and meta-analysis
- Review, NA, NA
Remission↑, tumor remission rate in the MLT group was significantly higher than that in the control group
OS↑, MLT group had an overall survival rate of 28.24% (n=294/1,041), which was greatly increased compared with the control group (RR =2.07; 95% CI, 1.55–2.76; P<0.00001; I2=55%)
neuroP↑, MLT could effectively reduce the incidence of neurotoxicity
VEGF↓, by the downregulation of vascular endothelial growth factor (VEGF)
KISS1↑, MLT could suppress the metastasis of triple-negative breast cancer by inducing KISS1 expression
TumCP↓, MLT can significantly inhibit the proliferation of cancer cells
ChemoSideEff↓, while reducing the incidence of side effects in chemotherapy or radiotherapy
radioP↑, In the 20 randomized trials included, MLT was beneficial to reduce multiple side effects of radiotherapy and chemotherapy
Dose∅, mostly 20 mg/day and taken orally and taken at night, respectively
*ROS↓, Preclinical experimental research has confirmed that MLT was capable of scavenging ROS and repairing damaged DNA to exert antitumor effects
DNArepair↑,
ROS↑, The mechanisms of MLT exerting antitumor effect might involve with other pathways, such as antiangiogenesis and pro-oxidant


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

KISS1↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNArepair↑, 1,  

Migration(tgid=13) ⓘ

TumCI↓, 1,   TumCP↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

VEGF↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose∅, 1,  

Functional Outcomes(tgid=23) ⓘ

ChemoSideEff↓, 1,   neuroP↑, 1,   OS↑, 1,   radioP↑, 1,   Remission↑, 1,  
Total Targets: 13

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↓, 1,  
Total Targets: 1

Scientific Paper Hit Count for: KISS1, KISS1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1186  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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