KeyT Cancer Research Results
KeyT, Keytones: Click to Expand ⟱
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A ketogenic diet is high in fats and low in carbohydrates, which shifts the body’s metabolism to produce ketone bodies (such as β-hydroxybutyrate and acetoacetate) as an alternative energy source.
The three main ketone bodies are:
-Beta-hydroxybutyrate (BHB): The most abundant and commonly measured ketone in the blood.
-Acetoacetate: Can be measured in both the blood and urine.
-Acetone: Often measured in the breath; it is a byproduct of acetoacetate breakdown.
1. Blood Ketone Meters (accurate, fast)
-Nutritional ketosis is often defined by BHB levels between 0.5 to 3.0 mmol/L.
2. Urine Ketone Strips (urine test may not accurately reflect blood levels)
3. Breath Ketone Analyzers(not always perfectly correlate with blood BHB concentrations.)
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Scientific Papers found: Click to Expand⟱
BG↓, KD alone significantly decreased blood glucose, slowed tumor growth, and increased mean survival time by 56.7% in mice with systemic metastatic cancer.
TumCG↓,
OS↑,
eff↑, While HBO2T alone did not influence cancer progression, combining the KD with HBO2T elicited a significant decrease in blood glucose, tumor growth rate, and 77.9% increase in mean survival time compared to controls.
Dose∅, Mice undergoing HBO2T received 100% O2 for 90 minutes at 1.5 ATM gauge (2.5 ATM absolute) three times per week (M, W, F) in a hyperbaric chamber (Model 1300B, Sechrist Industries, Anaheim, CA).
KeyT↑, only the KD+HBO2T animals showed significantly increased ketones compared to controls
eff↑, we hypothesized that combining these non-toxic treatments would provide a powerful, synergistic anti-cancer effect.
cachexia↓, While low carbohydrate or ketogenic diets promote weight loss in overweight individuals, they are also known to spare muscle wasting during conditions of energy restriction and starvation
ChemoSen↑, KD improves quality of life and enhances the efficacy of chemotherapy treatment in the clinic
*ROS↓, ketone body metabolism protects cells from oxidative damage by decreasing ROS production. cancer cells are unable to effectively metabolize ketone bodies; we do not expect that ketones would confer the same protective effects onto the cancer cells
ROS↑, HBO2T increases ROS production within the cell which can lead to membrane lipid peroxidation and cell death
lipid-P↑,
selectivity↑, KD weakens cancer cells by glucose restriction and the inherent anti-cancer effects of ketone bodies while simultaneously conferring a protective advantage to the healthy tissue capable of ketone metabolism.
toxicity∅, HBO2T should be considered a safe treatment for patients with varying malignancies and that there is no convincing evidence its use promotes cancer progression or recurrence
*KeyT↑, Although ketones were increased when supplementing with MCTs,
*Dose↝, Thirty grams of MCTs seems to be the safe maximal dosage to minimize adverse reactions during or after exercise.
eff↑, MCTs are a better immediate energy source than LCTs due to their rapid absorption and beta-oxidation. Only a very small percentage of MCTs (less than 2%) contribute to fat storage, and most MCTs are converted to energy for immediate use in the body.
*cognitive↑, After 109 days of CT, MoCA scores changed from a baseline value of 24–28, and MMSE scores changed from 23 to 28.
*KeyT↑, It is possible to induce ketosis without dietary modification with special fats called medium chain triglycerides (MCTs).
*KeyT↑, Consumption of sufficient quantities of caprylic triglyceride (CT) increases plasma concentrations of ketone bodies and may be beneficial in conditions of compromised glucose metabolism, such as AD.
*cognitive↑, rate of decline in MMSE scores appeared slower than previously published reports for patients treated with pharmacotherapy alone.
*eff↑, Caprylic triglyceride-based medical foods have been prescribed to patients with mild-to-moderate AD for several years based on results in clinical trials.6,7
*memory↑, Caregiver assessments indicated that most patients were stable or improved with respect to memory and ability to carry out activities of daily living.
*cognitive↑,
*KeyT↑, 20 g of caprylic triglyceride (CT) increases blood levels of beta-hydroxybutyrate (the major ketone body in humans) 2 hours post dose to a mean value of 0.39 mM,
*cognitive↑, showed a trend towards cognitive improvement on ADAS-Cog (MD = − 0.539; 95% CI, −1.239 - 0.161, I2 = 0%), and significantly improved cognition when combining ADAS-Cog with MMSE
*KeyT↑, MCTs can induce mild ketosis and may improve cognition in patients with mild cognitive impairment and Alzheimer’s disease.
*eff↑, The main approaches taken to date to increase ketones in blood and consequently brain, are through fasting (Mattson et al., 2018), exercising
*other↑, Human breast milk is a natural source of MCTs (Andreas et al., 2015), but, in adult life, the major food-derived sources of MCTs are palm kernel oil and coconut oil
*toxicity↓, MCT supplements are concentrated palm kernel and coconut oils and are generally considered safe
Showing Research Papers: 1 to 6 of 6
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6
Pathway results for Effect on Cancer / Diseased Cells:
Redox & Oxidative Stress ⓘ
lipid-P↑, 1, ROS↑, 1,
Core Metabolism/Glycolysis ⓘ
KeyT↑, 1,
Proliferation, Differentiation & Cell State ⓘ
TumCG↓, 1,
Drug Metabolism & Resistance ⓘ
ChemoSen↑, 1, Dose∅, 1, eff↑, 3, selectivity↑, 1,
Clinical Biomarkers ⓘ
BG↓, 1,
Functional Outcomes ⓘ
cachexia↓, 1, OS↑, 1, toxicity∅, 1,
Total Targets: 12
Pathway results for Effect on Normal Cells:
Redox & Oxidative Stress ⓘ
ROS↓, 1,
Core Metabolism/Glycolysis ⓘ
KeyT↑, 5,
Transcription & Epigenetics ⓘ
other↑, 1,
Drug Metabolism & Resistance ⓘ
Dose↝, 1, eff↑, 2,
Functional Outcomes ⓘ
cognitive↑, 4, memory↑, 1, toxicity↓, 1,
Total Targets: 8
Scientific Paper Hit Count for: KeyT, Keytones
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
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