cardioP Cancer Research Results

cardioP, cardioProtective: Click to Expand ⟱
Source:
Type:
CardioProtective


Scientific Papers found: Click to Expand⟱
3972- ACNs,    Recent Research on the Health Benefits of Blueberries and Their Anthocyanins
- Review, AD, NA - Review, Park, NA
*cardioP↑, *neuroP↑, *Inflam↓, *antiOx↓, *GutMicro↑, *Half-Life↑, *LDL↓, *adiP↓, *HDL↑, *CRP↓, *IL1β↓, *Risk↓, *Risk↓, *cognitive↑, *memory↑, *other↑, *BOLD↑, *NO↓, *MDA↓, *GSH↑, *VitC↑, *SOD↑, *GPx↑, *eff↓, *eff↓, *eff↓, *eff↝, *Risk↓,
5430- AG,    Review of the pharmacological effects of astragaloside IV and its autophagic mechanism in association with inflammation
- Review, Stroke, NA
*cardioP↑, *MitoP↑, *ROS↓, *mtDam↓, *neuroP↓, TumAuto↓, *AntiDiabetic↑,
5353- AL,    Aged Garlic Extract May Be Safe for Patients on Warfarin Therapy
- Human, Nor, NA
*AntiAg↑, *toxicity↓, *cardioP↑, *Dose↝,
5352- AL,    Anticancer potential of allicin: A review
- Review, Var, NA
*cardioP↑, *Bacteria↓, *Inflam↓, AntiTum↑, *DNAdam↓, TumCP↓, angioG↓, TumMeta↓,
5355- AL,    Mini-review: The health benefits and applications of allicin
- Review, Var, NA
*BioAv↑, *cardioP↑, *hepatoP↑, *RenoP↑, *Half-Life↝, *BioAv↓, *neuroP↑, *cognitive↑, *ROS↓, *lipid-P↓, *DNArepair↑, *ChemoSen↑,
5354- AL,    Therapeutic Potential of Allicin-Rich Garlic Preparations: Emphasis on Clinical Evidence toward Upcoming Drugs Formulation
- Review, Var, NA
*LDL↓, *antiOx↑, AntiCan↑, *cardioP↑, *BP↓, *Weight↓, NK cell↑, *AntiDiabetic↑, *GSH↑,
2559- AL,    Effect of the Garlic Pill in comparison with Plavix on Platelet Aggregation and Bleeding Time
- Human, Nor, NA
AntiAg↑, COX2↓, cardioP↑,
2558- AL,    Allicin, an Antioxidant and Neuroprotective Agent, Ameliorates Cognitive Impairment
- Review, AD, NA
*AntiCan↑, *antiOx↑, *cardioP↑, *neuroP↑, cognitive↑, *ROS↓, *NOX↓, *TLR4↓, *NF-kB↓, *JNK↓, *AntiAg↑, *H2S↑, *BP↓, Telomerase↓, *Insulin↑, BioAv↝, *GSH↑, *Catalase↑,
2657- AL,    Allicin pharmacology: Common molecular mechanisms against neuroinflammation and cardiovascular diseases
- Review, CardioV, NA - Review, AD, NA
*Inflam↓, *antiOx↑, *neuroP↑, *cardioP↑, *AntiTum↑, *mtDam↑, *HSP70/HSPA5↑, *NRF2↑, *RAAS↓, *cognitive↑, *SOD↑, *ROS↓, *NRF2↑, *ER Stress↓, *neuroP↑, *memory↑, *TBARS↓, *MPO↓, *SOD↑, *GSH↑, *iNOS↓, *p‑eNOS↑, *HO-1↑,
2658- AL,    The Toxic Effect Ways of Allicin on Different Cell Lines
- Review, Var, NA
*antiOx↑, *AntiAg↑, *cardioP↑, Ca+2↑, ROS↑, Casp↑, p38↑, MAPK↑, hepatoP↑, chemoP↑,
2660- AL,    Allicin: A review of its important pharmacological activities
- Review, AD, NA - Review, Var, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, AntiCan↑, *antiOx↑, *cardioP↑, *hepatoP↑, *BBB↑, *Half-Life↝, *H2S↑, *BP↓, *neuroP↑, *cognitive↑, *neuroP↑, *ROS↓, *GutMicro↑, *LDH↓, *ROS↓, *lipid-P↓, *antiOx↑, *other↑, *PI3K↓, *Akt↓, *NF-kB↓, *NO↓, *iNOS↓, *PGE2↓, *COX2↓, *IL6↓, *TNF-α↓, *MPO↓, *eff↑, *NRF2↑, *Keap1↓, *TBARS↓, *creat↓, *LDH↓, *AST↓, *ALAT↓, *MDA↓, *SOD↑, *GSH↑, *GSTs↑, *memory↑, chemoP↑, IL8↓, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Casp12↑, p38↑, Fas↑, P53↑, P21↑, CHK1↓, CycB/CCNB1↓, GSH↓, ROS↑, TumCCA↑, Hif1a↓, Bcl-2↓, VEGF↓, TumCMig↓, STAT3↓, VEGFR2↓, p‑FAK↓,
3272- ALA,    Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential
- Review, AD, NA
*antiOx↑, *glucose↑, *eNOS↑, *NRF2↑, *MMP9↓, *VCAM-1↓, *NF-kB↓, *cardioP↑, *cognitive↑, *eff↓, *BBB↑, *IronCh↑, *GSH↑, *PKCδ↑, *ERK↑, *p38↑, *MAPK↑, *PI3K↑, *Akt↑, *PTEN↓, *AMPK↑, *GLUT4↑, *GLUT1↑, *Inflam↓,
3438- ALA,    The Potent Antioxidant Alpha Lipoic Acid
- Review, NA, NA - Review, AD, NA
*antiOx↑, *cardioP↑, *cognitive↑, *AntiAge↑, *Inflam↓, *AntiCan↑, *neuroP↑, *IronCh↑, *ROS↑, *Weight↓, *Ach↑, *ROS↓, *GSH↑, *lipid-P↓, *memory↑, *NRF2↑, *ChAT↑, *GlucoseCon↑, *Acetyl-CoA↑,
3451- ALA,    Alpha-lipoic acid ameliorates H2O2-induced human vein endothelial cells injury via suppression of inflammation and oxidative stress
- in-vitro, Nor, HUVECs
*LDH↓, *NOX4↓, *NF-kB↓, *iNOS↓, *VCAM-1↓, *ICAM-1↓, *ROS↓, *cardioP↑,
2636- Api,    Apigenin unveiled: an encyclopedic review of its preclinical and clinical insights
- Review, NA, NA
*AntiCan↑, *cardioP↑, *neuroP↑, *Inflam↓, *antiOx↑, *hepatoP↑, ChemoSen↑,
4991- ART/DHA,  doxoR,    Dihydroartemisinin alleviates doxorubicin-induced cardiotoxicity and ferroptosis by activating Nrf2 and regulating autophagy
- in-vivo, Nor, H9c2
*cardioP↑, *ROS↓, *Ferroptosis↓, *NRF2↑, Keap1↓,
5413- ASA,    Drug Resistance and Pseudoresistance: An Unintended Consequence of Enteric Coating Aspirin
- Trial, Nor, NA
*cardioP↑, *other↝, *COX1↓, *TXA2↓,
5412- ASA,    Clinical Pharmacology of Aspirin
- Review, NA, NA
*COX1↓, *COX2↓, *cardioP↑, *BioAv↑, *BioAv↝, *Half-Life↓, Risk↓, *other↑, *AntiAg↑,
5411- ASA,    Mechanistic Insights into a Classic Wonder Drug—Aspirin
- Review, Var, NA
*COX2↓, *COX1↓, *Inflam↓, *cardioP↑, Risk↓,
3672- Ash,    Critical review of the Withania somnifera (L.) Dunal: ethnobotany, pharmacological efficacy, and commercialization significance in Africa
- Review, NA, NA
*cardioP↑, *antiOx↑, *ROS↓, *neuroP↑, *Inflam↓, *Apoptosis↓,
3166- Ash,    Exploring the Multifaceted Therapeutic Potential of Withaferin A and Its Derivatives
- Review, Var, NA
*p‑PPARγ↓, *cardioP↑, *AMPK↑, *BioAv↝, *Half-Life↝, *Half-Life↝, *Dose↑, *chemoPv↑, IL6↓, STAT3↓, ROS↓, OXPHOS↓, PCNA↓, LDH↓, AMPK↑, TumCCA↑, NOTCH3↓, Akt↓, Bcl-2↓, Casp3↑, Apoptosis↑, eff↑, NF-kB↓, CSCs↓, HSP90↓, PI3K↓, FOXO3↑, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, FASN↓, ACLY↓, ROS↑, NRF2↑, HO-1↑, NQO1↑, JNK↑, mTOR↓, neuroP↑, *TNF-α↓, *IL1β↓, *IL6↓, *IL8↓, *IL18↓, RadioS↑, eff↑,
4303- Ash,    Ashwagandha (Withania somnifera)—Current Research on the Health-Promoting Activities: A Narrative Review
- Review, AD, NA
*neuroP↑, *Sleep↑, *Inflam↓, *cardioP↑, *cognitive↑, *Aβ↓, *TNF-α↓, *IL1β↓, *IL6↓, *MCP1↓, *lipid-P↓, *tau↓, *ROS↓, *BBB↑, *AChE↓, *GSH↑, *GSTs↑, *GSR↑, *GPx↑, *SOD↑, *Catalase↑, ChemoSen↑, *Strength↑,
4814- ASTX,    Chemopreventive and therapeutic efficacy of astaxanthin against cancer: A comprehensive review
- Review, Var, NA
Apoptosis↑, EMT↓, AntiCan↑, *cardioP↑, *neuroP↑, TumCG↓, *antiOx↑, *Bacteria↓, *Imm↑, *hepatoP↑, *AntiDiabetic↑, ROS↓, *chemoPv↑,
5419- ASTX,    Astaxanthin and other Nutrients from Haematococcus pluvialis—Multifunctional Applications
- Review, Nor, NA
*antiOx↑, *Inflam↓, *AntiDiabetic↓, AntiCan↑, *lipid-P↓, TumCP↓, Apoptosis↑, TumCCA↑, *SOD↑, *PGE2↓, *NO↓, *IL8↓, *IFN-γ↓, *cardioP↑, *NF-kB↓, *TNF-α↓, *BioAv↑,
5421- ASTX,    Astaxanthin Inhibits PC-3 Xenograft Prostate Tumor Growth in Nude Mice
- in-vivo, Pca, NA
TumCG↑, Ki-67↑, PCNA↓, GutMicro↑, *Inflam↓, *cardioP↑, *ROS↓,
5448- ATV,    Beyond cardiovascular health: The pharmacotherapeutic potential of statins in oncology
- Review, Var, NA
Apoptosis↑, TumAuto↑, TumCCA↑, BioAv↓, eff↑, HMGCR↓, LDL↓, cardioP↑, AntiTum↑, ChemoSen↑, RadioS↑, toxicity↓,
5445- ATV,    Atorvastatin
- NA, Nor, NA
*cardioP↑, *LDL↓, HMG-CoA↓, Half-Life↝, BioAv↓, Dose↝,
4981- ATV,    Crosstalk between Statins and Cancer Prevention and Therapy: An Update
Apoptosis↑, selectivity↑, eff↑, HMG-CoA↓, *cardioP↑, OS↑, IL1β↓, IL6↓, IL8↓, TNF-α↓, TumAuto↑, Histones↝, ac‑H3↑, ac‑H4↑, HDAC↓,
5364- AV,    A New Biomaterial Derived from Aloe vera—Acemannan from Basic Studies to Clinical Application
- Review, Var, NA
BioAv↑, AntiTum↑, cardioP↑,
5248- Ba,  BA,  doxoR,    Baicalin and Baicalein Enhance Cytotoxicity, Proapoptotic Activity, and Genotoxicity of Doxorubicin and Docetaxel in MCF-7 Breast Cancer Cells
- in-vitro, BC, MCF-7 - in-vitro, Nor, HUVECs
toxicity↝, ChemoSen↑, selectivity↑, Apoptosis↑, necrosis↑, MMP↓, DNAdam↑, cl‑PARP↑, MRP1↓, Bcl-2↓, hepatoP↑, cardioP↑, BioAv↝,
2480- Ba,    Inhibition of 12/15 lipoxygenase by baicalein reduces myocardial ischemia/reperfusion injury via modulation of multiple signaling pathways
- in-vivo, Stroke, NA
*12LOX↓, *ROS↓, *ERK↑, *Akt↑, *p38↓, *JNK↓, *NF-kB↓, *cardioP↑,
2605- Ba,  BA,    Potential therapeutic effects of baicalin and baicalein
- Review, Var, NA - Review, Stroke, NA - Review, IBD, NA - Review, Arthritis, NA - Review, AD, NA - Review, Park, NA
cardioP↑, Inflam↓, cognitive↑, *hepatoP↑, *ROS?, *SOD↑, *GSH↑, *MMP↑, *GutMicro↑, ChemoSen↑, *TNF-α↓, *IL10↑, *IL6↓, *eff↑, *ROS↓, *COX2↓, *NF-kB↓, *STAT3↓, *PGE2↓, *MPO↓, *IL1β↓, *MMP2↓, *MMP9↓, *β-Amyloid↓, *neuroP↑, *Dose↝, *BioAv↝, *BioAv↝, *BBB↑, *BDNF↑,
2601- Ba,    Cardioprotective effects of baicalein on heart failure via modulation of Ca2 + handling proteins in vivo and in vitro
- in-vitro, Nor, NA - in-vivo, Nor, NA
*cardioP↑, *p‑Ca+2↓,
2626- Ba,    Molecular targets and therapeutic potential of baicalein: a review
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
AntiCan↓, *neuroP↑, *cardioP↑, *hepatoP↑, *RenoP↑, TumCCA↑, CDK4↓, cycD1/CCND1↓, cycE/CCNE↑, BAX↑, Bcl-2↓, VEGF↓, Hif1a↓, cMyc↓, NF-kB↓, ROS↑, BNIP3↑, *neuroP↑, *cognitive↑, *NO↓, *iNOS↓, *COX2↓, *PGE2↓, *NRF2↑, *p‑AMPK↑, *Ferroptosis↓, *lipid-P↓, *ALAT↓, *AST↓, *Fas↓, *BAX↓, *Apoptosis↓,
2294- Ba,    Baicalein attenuates cardiac hypertrophy in mice via suppressing oxidative stress and activating autophagy in cardiomyocytes
- in-vivo, Nor, NA
*Catalase↑, *ROS↓, *cardioP↑, *FOXO3?,
5552- BBM,    Effects of berbamine against myocardial ischemia/reperfusion injury: Activation of the 5' adenosine monophosphate‐activated protein kinase/nuclear factor erythroid 2‐related factor pathway and changes in the mitochondrial state
- in-vivo, Stroke, NA
*eff↑, *ROS↓, *mtDam↓, *AMPK↑, *NRF2↑, *NADPH↑, *HO-1↑, *cardioP↑,
2696- BBR,    Berberine regulates proliferation, collagen synthesis and cytokine secretion of cardiac fibroblasts via AMPK-mTOR-p70S6K signaling pathway
- in-vivo, Nor, NA
*α-SMA↓, *TGF-β1↓, *IL10↑, *p‑AMPK↑, *p‑mTOR↓, *P70S6K↓, *cardioP↑,
2678- BBR,    Berberine as a Potential Agent for the Treatment of Colorectal Cancer
- Review, CRC, NA
*Inflam↓, *antiOx↑, *cardioP↑, *neuroP↑, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDC2↓, AMPK↝, mTOR↝, Casp8↑, Casp9↑, Cyt‑c↑, TumCMig↓, TumCI↓, EMT↓, MMPs↓, E-cadherin↓, Telomerase↓, *toxicity↓, GRP78/BiP↓, EGFR↓, CDK4↓, COX2↓, PGE2↓, p‑JAK2↓, p‑STAT3↓, MMP2↓, MMP9↓, GutMicro↑, eff↝, *BioAv↓, BioAv↑,
2675- BBR,    The therapeutic effects of berberine against different diseases: A review on the involvement of the endoplasmic reticulum stress
- Review, Var, NA
*Inflam↓, *antiOx↑, *ER Stress↓, *cardioP↑, *RenoP↑, *hepatoP↑,
2676- BBR,    Berberine protects rat heart from ischemia/reperfusion injury via activating JAK2/STAT3 signaling and attenuating endoplasmic reticulum stress
- in-vivo, Nor, NA - in-vivo, CardioV, NA
*cardioP↑, *ROS↓, *ER Stress↓, *p‑PERK↓, *p‑eIF2α↓, *ATF4↓, CHOP↓, *JAK2↑, *STAT3↑, *UPR↓,
2684- BBR,    Berberine is a Novel Mitochondrial Calcium Uniporter Inhibitor that Disrupts MCU‐EMRE Assembly
- in-vivo, Nor, NA
*MCU↓, *mt-Ca+2↓, *cardioP↑,
3833- BBR,    Traditional Chinese Medicine: Role in Reducing β-Amyloid, Apoptosis, Autophagy, Neuroinflammation, Oxidative Stress, and Mitochondrial Dysfunction of Alzheimer’s Disease
- Review, AD, NA
*cardioP↑, *neuroP↑, *memory↑, *Aβ↓,
5633- BCA,    Mechanisms Behind the Pharmacological Application of Biochanin-A: A review
- Review, Var, NA - Review, AD, NA
*AntiDiabetic↑, *neuroP↑, *toxicity↓, *CYP19↓, p‑Akt↓, mTOR↓, TumCCA↑, P21↑, Casp3↑, Bcl-2↑, Apoptosis↑, E-cadherin↓, TumMeta↓, eff↑, GSK‐3β↓, β-catenin/ZEB1↓, RadioS↑, ROS↑, Casp1↑, MMP2↓, MMP9↓, EGFR↓, ChemoSen↑, PI3K↓, MMPs↓, Hif1a↓, VEGF↓, *ROS↓, *Obesity↓, *cardioP↑, *NRF2↑, *NF-kB↓, *Inflam↓, *lipid-P↓, *hepatoP↑, *AST↓, *ALP↓, *Bacteria↓, *neuroP↑, *SOD↑, *GPx↑, *AChE↓, *BACE↓, *memory↑, *BioAv↓,
5514- bemA,    Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients
- Trial, Nor, NA
*ACLY↓, *LDL↓, *MusCon↓, Dose↝, cardioP↑,
2771- BetA,    Cardioprotective Effect of Betulinic Acid on Myocardial Ischemia Reperfusion Injury in Rats
- in-vivo, Nor, NA - in-vivo, Stroke, NA
*cardioP↑, *LDH↓, eff↑,
3502- Bor,    Plasma boron concentrations in the general population: a cross-sectional analysis of cardio-metabolic and dietary correlates
- Review, NA, NA
*Half-Life↑, *VitD↑, *cardioP↑, *RenoP↓,
5708- Brut,    Clinical application of bergamot (Citrus bergamia) for reducing high cholesterol and cardiovascular disease markers
- Review, Nor, NA
*Imm↑, *cardioP↑, *LDL↓, toxicity↓,
5872- CA,    Nrf2/ARE-Mediated Antioxidant Actions of Pro-Electrophilic Drugs
- Review, Nor, NA
*NRF2↑, *GSH↑, *neuroP↑, *Inflam↓, *cardioP↑, *Obesity↓, *angioG↓, chemoP↑, *NF-kB↓,
5825- CAP,    Bioavailability of capsaicin and its implications for drug delivery
- Review, Var, NA - Review, Arthritis, NA - Review, Obesity, NA
*AntiCan↑, *TRPV1↑, *cardioP↑, AntiCan↓, Apoptosis↑, ChemoSen↑, *Inflam↓, *Pain↓, *AntiAg↑, *Weight↓, *BioAv↑, BioAv↑, Half-Life↝, Half-Life↓,
5858- CAP,    Capsaicin as a Microbiome Modulator: Metabolic Interactions and Implications for Host Health
- Review, Nor, NA - Review, AD, NA
*BBB↓, *GutMicro↑, Obesity↓, *Inflam↓, *AntiCan↑, *TRPV1↑, *Ca+2↑, *antiOx↑, *cardioP↑, *BioAv↓, *Half-Life↓, *BioAv↝, *BioAv↑, *neuroP↑, Apoptosis↑, p38↑, ROS↑, MMP↓, MPT↑, Cyt‑c↑, Casp↑, TRIB3↑, NADH↓, SIRT1↓, TumCG↓, TumCMig↓, TOP1↓, TOP2↓, β-catenin/ZEB1↓, *ROS↓, *Aβ↓,

Showing Research Papers: 1 to 50 of 198
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 198

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

GSH↓, 1,   HO-1↑, 1,   Keap1↓, 1,   NADH↓, 1,   NQO1↑, 1,   NRF2↑, 1,   OXPHOS↓, 1,   ROS↓, 2,   ROS↑, 6,  

Mitochondria & Bioenergetics ⓘ

CDC2↓, 1,   MMP↓, 2,   MPT↑, 1,  

Core Metabolism/Glycolysis ⓘ

ACLY↓, 1,   AMPK↑, 1,   AMPK↝, 1,   cMyc↓, 1,   FASN↓, 1,   Histones↝, 1,   HMG-CoA↓, 2,   LDH↓, 1,   LDL↓, 1,   SIRT1↓, 1,  

Cell Death ⓘ

Akt↓, 1,   p‑Akt↓, 1,   Apoptosis↑, 9,   BAX↑, 1,   Bcl-2↓, 4,   Bcl-2↑, 1,   Casp↑, 2,   Casp1↑, 1,   Casp12↑, 1,   Casp3↑, 3,   Casp8↑, 2,   Casp9↑, 2,   Cyt‑c↑, 3,   Fas↑, 1,   JNK↑, 1,   MAPK↑, 1,   necrosis↑, 1,   p38↑, 3,   Telomerase↓, 2,  

Transcription & Epigenetics ⓘ

ac‑H3↑, 1,   ac‑H4↑, 1,  

Protein Folding & ER Stress ⓘ

CHOP↓, 1,   GRP78/BiP↓, 1,   HSP90↓, 1,  

Autophagy & Lysosomes ⓘ

BNIP3↑, 1,   TumAuto↓, 1,   TumAuto↑, 2,  

DNA Damage & Repair ⓘ

CHK1↓, 1,   DNAdam↑, 1,   P53↑, 1,   cl‑PARP↑, 1,   PCNA↓, 2,  

Cell Cycle & Senescence ⓘ

CDK4↓, 2,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 2,   cycE/CCNE↓, 1,   cycE/CCNE↑, 1,   P21↑, 2,   TumCCA↑, 7,  

Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 1,   EMT↓, 3,   FOXO3↑, 1,   GSK‐3β↓, 1,   HDAC↓, 1,   HMGCR↓, 1,   mTOR↓, 2,   mTOR↝, 1,   NOTCH3↓, 1,   PI3K↓, 2,   STAT3↓, 2,   p‑STAT3↓, 1,   TOP1↓, 1,   TOP2↓, 1,   TumCG↓, 2,   TumCG↑, 1,  

Migration ⓘ

AntiAg↑, 1,   Ca+2↑, 1,   E-cadherin↓, 2,   p‑FAK↓, 1,   Ki-67↑, 1,   MMP2↓, 2,   MMP9↓, 2,   MMPs↓, 2,   N-cadherin↓, 1,   TRIB3↑, 1,   TumCI↓, 1,   TumCMig↓, 3,   TumCP↓, 2,   TumMeta↓, 2,   β-catenin/ZEB1↓, 3,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   EGFR↓, 2,   Hif1a↓, 3,   VEGF↓, 3,   VEGFR2↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 2,   IL1β↓, 1,   IL6↓, 2,   IL8↓, 2,   Inflam↓, 1,   p‑JAK2↓, 1,   NF-kB↓, 2,   NK cell↑, 1,   PGE2↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioAv↑, 3,   BioAv↝, 2,   ChemoSen↑, 7,   Dose↝, 2,   eff↑, 6,   eff↝, 1,   Half-Life↓, 1,   Half-Life↝, 2,   MRP1↓, 1,   RadioS↑, 3,   selectivity↑, 2,  

Clinical Biomarkers ⓘ

EGFR↓, 2,   GutMicro↑, 2,   IL6↓, 2,   Ki-67↑, 1,   LDH↓, 1,   TRIB3↑, 1,  

Functional Outcomes ⓘ

AntiCan↓, 2,   AntiCan↑, 4,   AntiTum↑, 3,   cardioP↑, 6,   chemoP↑, 3,   cognitive↑, 2,   hepatoP↑, 2,   neuroP↑, 1,   Obesity↓, 1,   OS↑, 1,   Risk↓, 2,   toxicity↓, 2,   toxicity↝, 1,  
Total Targets: 138

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   antiOx↑, 15,   Catalase↑, 3,   Ferroptosis↓, 2,   GPx↑, 3,   GSH↑, 10,   GSR↑, 1,   GSTs↑, 2,   HDL↑, 1,   HO-1↑, 2,   Keap1↓, 1,   lipid-P↓, 7,   MDA↓, 2,   MPO↓, 3,   NOX4↓, 1,   NRF2↑, 10,   ROS?, 1,   ROS↓, 19,   ROS↑, 1,   SOD↑, 8,   TBARS↓, 2,   VitC↑, 1,  

Metal & Cofactor Biology ⓘ

IronCh↑, 2,  

Mitochondria & Bioenergetics ⓘ

Insulin↑, 1,   MMP↑, 1,   mtDam↓, 2,   mtDam↑, 1,  

Core Metabolism/Glycolysis ⓘ

12LOX↓, 1,   Acetyl-CoA↑, 1,   ACLY↓, 1,   adiP↓, 1,   ALAT↓, 2,   AMPK↑, 3,   p‑AMPK↑, 2,   glucose↑, 1,   GlucoseCon↑, 1,   H2S↑, 2,   LDH↓, 4,   LDL↓, 5,   MCU↓, 1,   NADPH↑, 1,   p‑PPARγ↓, 1,  

Cell Death ⓘ

Akt↓, 1,   Akt↑, 2,   Apoptosis↓, 2,   BAX↓, 1,   Fas↓, 1,   Ferroptosis↓, 2,   iNOS↓, 4,   JNK↓, 2,   MAPK↑, 1,   p38↓, 1,   p38↑, 1,   TRPV1↑, 2,  

Transcription & Epigenetics ⓘ

Ach↑, 1,   other↑, 3,   other↝, 1,  

Protein Folding & ER Stress ⓘ

p‑eIF2α↓, 1,   ER Stress↓, 3,   HSP70/HSPA5↑, 1,   p‑PERK↓, 1,   UPR↓, 1,  

Autophagy & Lysosomes ⓘ

MitoP↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↓, 1,   DNArepair↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↑, 2,   FOXO3?, 1,   p‑mTOR↓, 1,   P70S6K↓, 1,   PI3K↓, 1,   PI3K↑, 1,   PTEN↓, 1,   STAT3↓, 1,   STAT3↑, 1,  

Migration ⓘ

AntiAg↑, 5,   Ca+2↑, 1,   p‑Ca+2↓, 1,   mt-Ca+2↓, 1,   MMP2↓, 1,   MMP9↓, 2,   PKCδ↑, 1,   TGF-β1↓, 1,   VCAM-1↓, 2,   α-SMA↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   ATF4↓, 1,   eNOS↑, 1,   p‑eNOS↑, 1,   NO↓, 4,   TXA2↓, 1,  

Barriers & Transport ⓘ

BBB↓, 1,   BBB↑, 4,   GLUT1↑, 1,   GLUT4↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX1↓, 3,   COX2↓, 5,   CRP↓, 1,   ICAM-1↓, 1,   IFN-γ↓, 1,   IL10↑, 2,   IL18↓, 1,   IL1β↓, 4,   IL6↓, 4,   IL8↓, 2,   Imm↑, 2,   Inflam↓, 18,   JAK2↑, 1,   MCP1↓, 1,   NF-kB↓, 9,   PGE2↓, 4,   TLR4↓, 1,   TNF-α↓, 5,   VitD↑, 1,  

Cellular Microenvironment ⓘ

NOX↓, 1,  

Synaptic & Neurotransmission ⓘ

AChE↓, 2,   BDNF↑, 1,   ChAT↑, 1,   tau↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 3,   BACE↓, 1,   β-Amyloid↓, 1,  

Hormonal & Nuclear Receptors ⓘ

CYP19↓, 1,   RAAS↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 4,   BioAv↑, 5,   BioAv↝, 5,   ChemoSen↑, 1,   Dose↑, 1,   Dose↝, 2,   eff↓, 4,   eff↑, 3,   eff↝, 1,   Half-Life↓, 2,   Half-Life↑, 2,   Half-Life↝, 4,  

Clinical Biomarkers ⓘ

ALAT↓, 2,   ALP↓, 1,   AST↓, 3,   BP↓, 3,   creat↓, 1,   CRP↓, 1,   GutMicro↑, 4,   IL6↓, 4,   LDH↓, 4,   VitD↑, 1,  

Functional Outcomes ⓘ

AntiAge↑, 1,   AntiCan↑, 5,   AntiDiabetic↓, 1,   AntiDiabetic↑, 4,   AntiTum↑, 1,   BOLD↑, 1,   cardioP↑, 44,   chemoPv↑, 2,   cognitive↑, 8,   hepatoP↑, 8,   memory↑, 6,   MusCon↓, 1,   neuroP↓, 1,   neuroP↑, 21,   Obesity↓, 2,   Pain↓, 1,   RenoP↓, 1,   RenoP↑, 3,   Risk↓, 3,   Sleep↑, 1,   Strength↑, 1,   toxicity↓, 3,   Weight↓, 3,  

Infection & Microbiome ⓘ

Bacteria↓, 3,  
Total Targets: 169

Scientific Paper Hit Count for: cardioP, cardioProtective
11 doxorubicin
11 Lycopene
11 Quercetin
11 Thymoquinone
9 Allicin (mainly Garlic)
9 Resveratrol
8 Chlorogenic acid
7 Carvacrol
6 Baicalein
6 Berberine
6 EGCG (Epigallocatechin Gallate)
5 Coenzyme Q10
5 Honokiol
4 Aspirin -acetylsalicylic acid
4 Atorvastatin
4 Chocolate
4 Chrysin
4 Sulforaphane (mainly Broccoli)
4 Silymarin (Milk Thistle) silibinin
3 Alpha-Lipoic-Acid
3 Ashwagandha(Withaferin A)
3 Astaxanthin
3 Thymol-Thymus vulgaris
3 Cinnamon
3 Spermidine
3 Hydrogen Gas
3 Magnetic Fields
3 Rosmarinic acid
3 Urolithin
3 Vitamin K2
2 Baicalin
2 Capsaicin
2 Choline
2 Selenium
2 Chemotherapy
2 Ferulic acid
2 Fisetin
2 Luteolin
2 Magnolol
2 Metformin
2 Piperine
2 Pterostilbene
2 Shikonin
1 Anthocyanins
1 Astragalus
1 Apigenin (mainly Parsley)
1 Artemisinin
1 Aloe anthraquinones
1 Berbamine
1 Biochanin A
1 bempedoic acid
1 Betulinic acid
1 Boron
1 Bruteridin(bergamot juice)
1 Carnosic acid
1 Calorie Restriction Mimetics
1 Hydroxycinnamic-acid
1 Curcumin
1 diet Short Term Fasting
1 Dipyridamole
1 Ellagic acid
1 Emodin
1 Melatonin
1 Moringa oleifera
1 nicotinamide adenine dinucleotide
1 Naringin
1 Phenylbutyrate
1 Propolis -bee glue
1 Piperlongumine
1 Psoralidin
1 Rutin
1 Selenium NanoParticles
1 Shankhpushpi
1 Taurine
1 Ursolic acid
1 Vitamin B3,Niacin
1 Vitamin E
1 probiotics
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1188  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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