Insulin Cancer Research Results

Insulin, Insulin: Click to Expand ⟱
Source:
Type:
Insulin, traditionally known for its role in regulating blood glucose levels, also exerts potent mitogenic (cell division–promoting) effects.

Insulin exerts its effects primarily through binding to the insulin receptor (IR), a receptor tyrosine kinase. Upon binding, the receptor undergoes autophosphorylation and activates several downstream signaling cascades, including:
-PI3K/Akt Pathway: Overactivation of this pathway is often observed in cancers.
-RAS/MAPK Pathway: aberrant activation can lead to tumorigenesis.

IR-A: Often predominates in fetal tissues and some cancer cells. It has a higher affinity for insulin-like growth factors (IGFs) and is more mitogenic.
IR-B: More involved in metabolic regulation.

Studies have shown that many cancers (such as breast, colon, and lung cancers) preferentially overexpress the IR-A isoform.
Scientific Papers found: Click to Expand⟱
2558- AL,    Allicin, an Antioxidant and Neuroprotective Agent, Ameliorates Cognitive Impairment
- Review, AD, NA
*AntiCan↑, *antiOx↑, *cardioP↑, *neuroP↑, cognitive↑, *ROS↓, *NOX↓, *TLR4↓, *NF-kB↓, *JNK↓, *AntiAg↑, *H2S↑, *BP↓, Telomerase↓, *Insulin↑, BioAv↝, *GSH↑, *Catalase↑,
2637- Api,    Apigenin Alleviates Endoplasmic Reticulum Stress-Mediated Apoptosis in INS-1 β-Cells
- in-vitro, Diabetic, NA
*other↝, *Insulin↑, ER Stress↓, *CHOP↓, *cl‑Casp3↓, *ROS↓, *Inflam↓, *TXNIP↓,
5631- BCA,    Perspectives Regarding the Role of Biochanin A in Humans
- Review, Var, NA - Review, AD, NA
*BioAv↓, *Inflam↓, AntiCan↑, *neuroP↑, chemoPv↑, Dose↝, *SOD↑, *MDA↓, *BAX↓, *HSP70/HSPA5↑, *AntiDiabetic↑, *Insulin↑, *TNF-α↓, *IL1β↓, *IL6↓, *iNOS↓, *COX2↓, *MMP9↓, *ROS↓, *PGE2↓, *BACE↓, *BioAv↑, P-gp⇅,
5842- CAP,    Capsaicin: Current Understanding of Its Mechanisms and Therapy of Pain and Other Pre-Clinical and Clinical Uses
- Review, Nor, NA - Review, Diabetic, NA
*Pain↓, *TRPV1↑, AMPK↑, ROS↑, TumCP↑, Apoptosis↑, TumCCA↑, Casp3↑, BAX↑, Bak↑, cl‑PARP↑, Bcl-2↓, RNS↑, *glucose↓, *Insulin↑, *BP↓, *AntiAg↑, ER Stress↑, Hif1a↓, chemoPv↑,
5824- CAP,    Pharmacokinetic and the effect of capsaicin in Capsicum frutescens on decreasing plasma glucose level
- Study, Diabetic, NA
*glucose↓, *Insulin↑, *Dose↑, *AntiDiabetic↑,
4490- Chit,  FA,    Chitosan Nanoparticle-Based Drug Delivery Systems: Advances, Challenges, and Future Perspectives
- Review, NA, NA
EPR↑, *BioAv↑, *eff↑, *other↝, *Insulin↑, *Bacteria↓, eff↑, ChemoSen↑,
2862- FIS,    Fisetin averts oxidative stress in pancreatic tissues of streptozotocin-induced diabetic rat
- in-vivo, Diabetic, NA
*BG↓, *NF-kB↓, *IL1β↓, *NO↓, *Insulin↑, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑,

Showing Research Papers: 1 to 7 of 7

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 7

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

RNS↑, 1,   ROS↑, 1,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   Bak↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   Telomerase↓, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↓, 1,   ER Stress↑, 1,  

DNA Damage & Repair ⓘ

cl‑PARP↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Migration ⓘ

TumCP↑, 1,  

Angiogenesis & Vasculature ⓘ

EPR↑, 1,   Hif1a↓, 1,  

Barriers & Transport ⓘ

P-gp⇅, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↝, 1,   ChemoSen↑, 1,   Dose↝, 1,   eff↑, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   chemoPv↑, 2,   cognitive↑, 1,  
Total Targets: 24

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Catalase↑, 2,   GPx↑, 1,   GSH↑, 1,   GSTs↑, 1,   MDA↓, 1,   ROS↓, 3,   SOD↑, 2,  

Mitochondria & Bioenergetics ⓘ

Insulin↑, 7,  

Core Metabolism/Glycolysis ⓘ

glucose↓, 2,   H2S↑, 1,  

Cell Death ⓘ

BAX↓, 1,   cl‑Casp3↓, 1,   iNOS↓, 1,   JNK↓, 1,   TRPV1↑, 1,  

Transcription & Epigenetics ⓘ

other↝, 2,  

Protein Folding & ER Stress ⓘ

CHOP↓, 1,   HSP70/HSPA5↑, 1,  

Migration ⓘ

AntiAg↑, 2,   MMP9↓, 1,   TXNIP↓, 1,  

Angiogenesis & Vasculature ⓘ

NO↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   IL1β↓, 2,   IL6↓, 1,   Inflam↓, 2,   NF-kB↓, 2,   PGE2↓, 1,   TLR4↓, 1,   TNF-α↓, 1,  

Cellular Microenvironment ⓘ

NOX↓, 1,  

Protein Aggregation ⓘ

BACE↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 2,   Dose↑, 1,   eff↑, 1,  

Clinical Biomarkers ⓘ

BG↓, 1,   BP↓, 2,   IL6↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   AntiDiabetic↑, 2,   cardioP↑, 1,   neuroP↑, 2,   Pain↓, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 1,  
Total Targets: 46

Scientific Paper Hit Count for: Insulin, Insulin
2 Capsaicin
1 Allicin (mainly Garlic)
1 Apigenin (mainly Parsley)
1 Biochanin A
1 chitosan
1 Folic Acid, Vit B9
1 Fisetin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1190  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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