Thiols Cancer Research Results
Thiols, Thiols: Click to Expand ⟱
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"Thiols" generally refer to compounds containing sulfhydryl (–SH) groups, with glutathione (GSH) being one of the most abundant and well-studied cellular thiols. Thiol groups play essential roles in maintaining redox balance, detoxifying reactive oxygen species (ROS), and modulating protein function via post-translational modifications.
• Elevated levels of glutathione and related thiols have been associated with enhanced resistance to chemotherapy and radiation, as these treatments often work by inducing oxidative damage.
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Scientific Papers found: Click to Expand⟱
*AChE↓, aqueous and methanolic saffron extract presented a moderate activity as AChE inhibitor (up to 30%),
*memory↑, f 50-200 mg/kg of crocin enhanced memory impairment
*cognitive↑, crocin (30 mg/kg) for 3 weeks significantly improved cognitive impairment caused by intracerebroventricular injection of STZ,
*MDA↑, improved cognitive tasks and produced a significant decrease of malondialdehyde (MDA) levels and increase of total thiol content and glutathione peroxidase (GPx) activity in STZ-lesioned rats
*Thiols↑,
*GPx↑,
*antiOx↑, crocetin is only one and strong antioxidant, providing protection in rescuing cell viability, blocking reactive oxygen species (ROS) production and reducing caspase-3 activation
*ROS↓, crocin can prevent oxidative stress damage to hippocampus, memory and learning impairments
*Casp3↓,
*neuroP↑, neuroprotective effects of crocin against AD
*SOD↑, increase the levels of glutathione peroxidase, superoxide dismutase, acetylcholine and choline acetyltransferase,
*Ach↑,
*ChAT↑,
*BBB↑, shown that crocetin, able to pass through BBB, inhibits fibril Aβ formation,
*Aβ↓,
*tau↓, inhibitory effects of crocin on tau protein neurofibrillary tangles in AD.
*cognitive↑, (15 mg twice a day) or a capsule of placebo (two capsules a day) for 16 weeks. The results of this study indicated that saffron produces a significant improvement in cognitive performance
*Inflam↓, anticholinergic, anti-inflammatory and antioxidant features
*memory↑, value of saffron and its’ components, alone, or in combination with the other pharmaceuticals, for improving learning and memory abilities and controlling seizures
*cognitive↑, use of saffron in cognitive disturbance and epilepsy
*BioAv↑, Crocin is converted to crocetin by gastrointestinal cells (Hosseini et al., 2018), and is then absorbed and distributed to body tissues including the central nervous system
*ROS↓, -pretreated rats, cognitive performance was restored through attenuation of oxidative stress
*IL1↓, Crocin suppressed formation of advanced glycation products and brain inflammatory mediators [interleukin (IL)-1, tumor necrosis factor (TNF)-α, and nuclear factor (NF)-κB].
*TNF-α↓,
*NF-kB↓,
*neuroP↑, neuroprotective effects against oxidative stress was suggested to be related to increases in phosphoinositide 3-kinase/Akt and mitogen-activated protein kinases/extracellular signal-regulated kinases
*lipid-P↓, Reduced lipid peroxidation and DNA injury and restored thiol redox and antioxidant status
*Thiols↑,
*antiOx↑,
*AChE↓, restoring oxidative damage biomarkers including glutathion and lipid peroxidation as well as modulating the activities of acetylcholinesterase (AChE) and monoamine oxidase (MAO)
*MAOA↝,
*SIRT1↑, up-regulate the SIRT1/PGC-1α pathway.
*PGC-1α↑,
*Ach↑, increases synaptic acetylcholine levels
*antiOx↑, Rats in Group 4 (cadmium-exposed and Rosmarinic acid-accessed) exhibited increased levels of total proteins, a significant increase in the levels of antioxidant markers including total thiols, glutathione, total antioxidant capacity (TAC),
*Thiols↑,
*GSH↑,
*TAC↑, decreased levels of total thiols, GSH, catalase, and TAC
*SOD↑, superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase, and a significant decrease in the levels of blood cadmium, ALP, ALT, AST, creatinine, blood urea nitrogen (BUN), urea, bilirubin, and oxidation markers (H2O2, and MDA
*GPx↑,
*Catalase↑,
*ALP↓,
*ALAT↓,
*AST↓,
*creat↓,
*BUN↓,
*H2O2↓,
*MDA↓,
*ROS↓, significantly help attenuate the oxidative stress induced by cadmium
cardioP↑, benefits of RA are attributed to its anti-cancer, anti-depressive, antiallergic, anti-inflammatory, anti-angiogenic, cardioprotective, hepatoprotective, nephroprotective, neuroprotective, antimicrobial, hypoglycemic, and hypolipidemic bioactivities
hepatoP↑,
neuroP↑,
*hepatoP↑, TQ, THY and alpha-hederin (α-hederin) provide protection to liver
*lipid-P↓, inhibition of iron-dependent lipid peroxidation
*Thiols↑, elevation in total thiol content and (GSH) level,
*ROS↓, radical scavenging,
*Catalase↑, increasing the activity of quinone reductase, catalase, superoxide dismutase (SOD) and glutathione transferase (GST), inhibition of NF-κB activity
*SOD↑,
*GSTs↑,
*NF-kB↓,
*COX2↓, inhibition of both (COX) and (LOX) protects liver from injuries
*LOX1↓,
*Inflam↓, anti-inflammatory, anti-oxidant, and anti-apoptotic properties in several disorders such as asthma, hypertension, diabetes, inflammation, bronchitis, headache, eczema, fever, dizziness and influenza
*antiOx↑, anti-inflammatory and anti-oxidant effects via several molecular pathways
*COX2↓, TQ has been shown to suppress COX2 expression and the ensuing generation of prostaglandins
*NRF2↑, TQ also attenuates inflammation via the Nrf2 pathway [28]. Heme-oxygenase 1 (HO-1) has been shown to be stimulated by TQ
*HO-1↑,
*IL1β↓, oral TQ treatment caused a decrease in several pro-inflammatory regulators, such as interleukin 1 beta (IL-1β), interleukin 6 (IL-6), tumor necrosis factor (TNFα), interferon γ (IFNγ) and prostaglandin E2 PGE(2)
*IL6↓,
*TNF-α↓,
*IFN-γ↓,
*PGE2↓,
*cardioP↑, Cardioprotective activity of TQ through anti-inflammation
*Catalase↑, LPS diminished anti-oxidant enzymes including catalase (CAT) and superoxide dismutase (SOD) and the total thiol group. TQ treatment reduced these effects, restoring many of the LPS effects to basal levels
*SOD↑,
*Thiols↑,
*neuroP↑, Neuroprotective activity of TQ through anti-inflammation
*IL12↓, TQ diminished the levels of several cytokines such as IL-6, IL-1β, IL-12p40/70, chemokine C-C motif ligand 12 (CCL12)/monocyte chemotactic protein 5 (MCP-5), CCL2/MCP-1, granulocyte colony-stimulating factor (GCSF), and C-X-C motif chemokine 10 (Cxcl
*MCP1↓,
*CXCc↓,
*ROS↓, consistent with TQ’s efficacy in reducing ROS generation and the ensuing inflammation
Showing Research Papers: 1 to 5 of 5
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5
Pathway results for Effect on Cancer / Diseased Cells:
Functional Outcomes ⓘ
cardioP↑, 1, hepatoP↑, 1, neuroP↑, 1,
Total Targets: 3
Pathway results for Effect on Normal Cells:
Redox & Oxidative Stress ⓘ
antiOx↑, 4, Catalase↑, 3, GPx↑, 2, GSH↑, 1, GSTs↑, 1, H2O2↓, 1, HO-1↑, 1, lipid-P↓, 2, MDA↓, 1, MDA↑, 1, NRF2↑, 1, ROS↓, 5, SOD↑, 4, TAC↑, 1, Thiols↑, 5,
Mitochondria & Bioenergetics ⓘ
PGC-1α↑, 1,
Core Metabolism/Glycolysis ⓘ
ALAT↓, 1, BUN↓, 1, SIRT1↑, 1,
Cell Death ⓘ
Casp3↓, 1,
Transcription & Epigenetics ⓘ
Ach↑, 2,
Angiogenesis & Vasculature ⓘ
LOX1↓, 1,
Barriers & Transport ⓘ
BBB↑, 1,
Immune & Inflammatory Signaling ⓘ
COX2↓, 2, CXCc↓, 1, IFN-γ↓, 1, IL1↓, 1, IL12↓, 1, IL1β↓, 1, IL6↓, 1, Inflam↓, 2, MCP1↓, 1, NF-kB↓, 2, PGE2↓, 1, TNF-α↓, 2,
Synaptic & Neurotransmission ⓘ
AChE↓, 2, ChAT↑, 1, MAOA↝, 1, tau↓, 1,
Protein Aggregation ⓘ
Aβ↓, 1,
Drug Metabolism & Resistance ⓘ
BioAv↑, 1,
Clinical Biomarkers ⓘ
ALAT↓, 1, ALP↓, 1, AST↓, 1, creat↓, 1, IL6↓, 1,
Functional Outcomes ⓘ
cardioP↑, 1, cognitive↑, 3, hepatoP↑, 1, memory↑, 2, neuroP↑, 3,
Total Targets: 51
Scientific Paper Hit Count for: Thiols, Thiols
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
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