ChemChap Cancer Research Results

ChemChap, chemical chaperones: Click to Expand ⟱
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Chemical chaperones are small molecules that assist proteins in folding correctly, thereby reducing misfolding and aggregation.
-Cancer cells often exhibit high levels of protein synthesis and stress on the protein-folding machinery (such as the endoplasmic reticulum, ER). Misfolded proteins can lead to ER stress and activate the unfolded protein response (UPR). Chemical chaperones can help alleviate this stress by assisting in proper protein folding and reducing aggregation, potentially affecting the survival and proliferation of cancer cells.

-4-Phenylbutyric acid (4-PBA): One of the most extensively studied chemical chaperones, 4-PBA has been researched for its ability to reduce ER stress in various cellular models, including cancer. -Tauroursodeoxycholic acid (TUDCA): Another chemical chaperone that has been investigated for similar properties in alleviating ER stress.

-Challenges: The dual role of the UPR in both cell survival and death means that the context of treatment is crucial. Moreover, systemic administration of chemical chaperones might affect normal tissues, so selectivity and dosing become important considerations.
Scientific Papers found: Click to Expand⟱
2029- PB,    Phenylbutyric Acid: simple structure - multiple effects
- Review, Var, NA
NH3↓, enabling excretion of toxic ammonia, thus acting as ammonia scavenger
HDAC↓, histone deacetylase inhibiting
ChemChap↑, serving as chemical chaperone

2030- PB,    4-Phenylbutyric acid protects against neuronal cell death by primarily acting as a chemical chaperone rather than histone deacetylase inhibitor
- Review, Nor, NA
*HDAC↓, Their relative human histone deacetylase (HDAC) inhibitory activities were consistent with a structural model of their binding to HDAC7
*neuroP↑, their ability to suppress neuronal cell death and activity of chemical chaperone in vitro
*ChemChap↑, activity of chemical chaperone in vitro

2031- PB,    Phenylbutyrate is a multifaceted drug that exerts neuroprotective effects and reverses the Alzheimer´s disease-like phenotype of a commonly used mouse model
- in-vivo, AD, NA
*neuroP↑, treatment with PBA but not NaBu prevented the neuronal loss in the hippocampus of hAPPWT
*HDAC↓, In addition to its activity as a HDAC inhibitor, the chaperone activity of PBA appears to at least partially, mediate its reversal of the AD phenotype in Tg2576 mice and its neuroprotective effect in a model of hippocampal neuronal loss.
*ChemChap↑,


Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

NH3↓, 1,  

Protein Folding & ER Stress ⓘ

ChemChap↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

HDAC↓, 1,  
Total Targets: 3

Pathway results for Effect on Normal Cells:


Protein Folding & ER Stress ⓘ

ChemChap↑, 2,  

Proliferation, Differentiation & Cell State ⓘ

HDAC↓, 2,  

Functional Outcomes ⓘ

neuroP↑, 2,  
Total Targets: 3

Scientific Paper Hit Count for: ChemChap, chemical chaperones
3 Phenylbutyrate
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1230  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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