Histones Cancer Research Results

Histones, Histones: Click to Expand ⟱
Source:
Type:
Histones play a crucial role in regulating gene expression, and this regulatory mechanism is central to many aspects of brain development, function, and plasticity.

-Histone Acetylation: Often associated with active gene transcription. Enzymes known as histone acetyltransferases (HATs) add acetyl groups that reduce the positive charge on histones, weakening their interaction with the negatively charged DNA and thereby promoting gene expression.
-Histone Methylation: Depending on the specific amino acid residue and the number of methyl groups added, histone methylation can either activate or repress transcription. For instance, methylation on lysine 4 of histone H3 (H3K4me) is commonly linked to gene activation, whereas methylation on lysine 9 (H3K9me) is typically associated with gene repression.
Scientific Papers found: Click to Expand⟱
5651- BNL,  Cisplatin,    Natural borneol sensitizes human glioma cells to cisplatin-induced apoptosis by triggering ROS-mediated oxidative damage and regulation of MAPKs and PI3K/AKT pathway
- in-vitro, GBM, U251 - in-vitro, GBM, U87MG
ChemoSen↑, NB synergistically enhanced the anticancer efficacy of cisplatin in human glioma cells.
tumCV↓, Co-treatment of 40 μg/mL NB and 40 μg/mL cisplatin significantly inhibited U251 cell viability from 100% to 28.2% and increased the sub-G1 population from 1.4% to 59.3%.
TumCCA↑,
Apoptosis↑, NB enhanced cisplatin-induced apoptosis by activating caspases and triggering reactive oxygen species (ROS) overproduction
ROS↑,
DNAdam↑, ROS-mediated DNA damage was observed as reflected by the activation of ATM/ATR, p53 and histone.
ATR↑,
ATM↑,
P53↑,
Histones↑,
eff↓, ROS inhibition by antioxidants effectively improved MAPKs and PI3K/AKT functions and cell viability, indicating that NB enhanced cisplatin-induced cell growth in a ROS-dependent manner.
Casp3↑, the activation of caspase −3, −7, and −9 was further enhanced after the combination of 40 µg/mL of NB
Casp7↑,
Casp9↑,

2033- PB,    Phenylbutyrate ameliorates cognitive deficit and reduces tau pathology in an Alzheimer's disease mouse model
- in-vivo, AD, NA
*p‑tau↓, phosphorylated form of tau was decreased in the AD mouse brain after 4-PBA treatment
*GSK‐3β↓, effect probably due to an increase in the inactive form of the glycogen synthase kinase 3beta (GSK3beta)
*ac‑Histones↑, administration of 4-PBA restored brain histone acetylation levels
*neuroP↑,

2203- SK,    Shikonin suppresses small cell lung cancer growth via inducing ATF3-mediated ferroptosis to promote ROS accumulation
- in-vitro, Lung, NA
TumCP↓, shikonin effectively suppressed cell proliferation, apoptosis, migration, invasion, and colony formation and slightly induced apoptosis in SCLC cells
Apoptosis↓,
TumCMig↓,
TumCI↓,
Ferroptosis↑, shikonin could also induced ferroptosis in SCLC cells
ERK↓, Shikonin treatment effectively suppressed the activation of ERK, the expression of ferroptosis inhibitor GPX4, and elevated the level of 4-HNE, a biomarker of ferroptosis
GPx4↓,
4-HNE↑, elevated the level of 4-HNE, a biomarker of ferroptosis
ROS↑, ROS and lipid ROS were increased, while the GSH levels were decreased in SCLC cells after shikonin treatment.
GSH↓,
ATF3↑, shikonin activated ATF3 transcription by impairing the recruitment of HDAC1 mediated by c-myc on the ATF3 promoter, and subsequently elevating of histone acetylation
HDAC1↓,
ac‑Histones↑,


Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

4-HNE↑, 1,   ATF3↑, 1,   Ferroptosis↑, 1,   GPx4↓, 1,   GSH↓, 1,   ROS↑, 2,  

Core Metabolism/Glycolysis ⓘ

Histones↑, 1,   ac‑Histones↑, 1,  

Cell Death ⓘ

Apoptosis↓, 1,   Apoptosis↑, 1,   Casp3↑, 1,   Casp7↑, 1,   Casp9↑, 1,   Ferroptosis↑, 1,  

Transcription & Epigenetics ⓘ

tumCV↓, 1,  

DNA Damage & Repair ⓘ

ATM↑, 1,   ATR↑, 1,   DNAdam↑, 1,   P53↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↓, 1,   HDAC1↓, 1,  

Migration ⓘ

TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   eff↓, 1,  
Total Targets: 27

Pathway results for Effect on Normal Cells:


Core Metabolism/Glycolysis ⓘ

ac‑Histones↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

GSK‐3β↓, 1,  

Synaptic & Neurotransmission ⓘ

p‑tau↓, 1,  

Functional Outcomes ⓘ

neuroP↑, 1,  
Total Targets: 4

Scientific Paper Hit Count for: Histones, Histones
1 borneol
1 Cisplatin
1 Phenylbutyrate
1 Shikonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1232  State#:%  Dir#:2
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