Diff Cancer Research Results

Diff, differentiation: Click to Expand ⟱
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Differentiation refers to the process by which cells become specialized in structure and function.
-In healthy tissues, cells undergo differentiation to become specialized types (e.g., muscle cells, neurons, blood cells) that perform specific functions. This process is tightly regulated by genetic and epigenetic factors.
-In some cases, cells can lose their specialized characteristics, a process known as dedifferentiation. This is often seen in cancer, where tumor cells revert to a more primitive, less differentiated state.
Scientific Papers found: Click to Expand⟱
5466- AF,    Auranofin Inhibition of Thioredoxin Reductase in a Preclinical Model of Small Cell Lung Cancer
- in-vivo, Lung, NA
TrxR↓, Dose↝, RadioS↑, ChemoSen↑, ROS↑, Diff↑, toxicity↓,
4365- AgNPs,    Biomedical Applications of Silver Nanoparticles: An Up-to-Date Overview
- Review, Var, NA
ROS↑, *toxicity↓, *Bacteria↓, *Inf↓, *Diff↑, *eff↑, RadioS↑, selectivity↑,
3396- ART/DHA,    Progress on the study of the anticancer effects of artesunate
- Review, Var, NA
TumCP↓, TumCI↓, TumCMig↓, Apoptosis↑, Diff↑, TumAuto↑, angioG↓, TumCCA↑, ROS↑, AMPK↑, mTOR↑, ChemoSen↑, Tf↑, Ferroptosis↑, Ferritin↓, lipid-P↑, CDK1↑, CDK2↑, CDK4↑, CDK6↑, SIRT1↑, COX2↓, IL1β↓, survivin↓, DNAdam↑, RadioS↑,
4992- ART/DHA,    Dihydroartemisinin Increases the Sensitivity of Acute Myeloid Leukemia Cells to Cytarabine via the Nrf2/HO-1 Anti-Oxidant Signaling Pathway
- in-vitro, AML, HL-60
Apoptosis↑, Diff↑, ROS↓, HO-1↓, NRF2∅,
2798- CHr,    Chrysin: a histone deacetylase 8 inhibitor with anticancer activity and a suitable candidate for the standardization of Chinese propolis
- in-vitro, BC, MDA-MB-231 - in-vivo, NA, NA
HDAC↓, HDAC8↓, TumCG↓, Diff↑,
5520- EP,    Nanosecond Pulsed Electric Field (nsPEF): Opening the Biotechnological Pandora’s Box
- Review, Var, NA
Ca+2↑, Apoptosis↑, Diff↑, TumCP↓, Wound Healing↑, CellMemb↑, VGCC↑, VGSC↑, DNAdam↑, selectivity↑,
2511- H2,    Molecular hydrogen suppresses glioblastoma growth via inducing the glioma stem-like cell differentiation
- in-vivo, GBM, U87MG
TumCG↓, OS↑, CD133↓, Ki-67↓, angioG↓, Diff↑, TumCMig↓, TumCI↓, Dose↝, BBB↑, mt-ROS↑,
4233- LEC,    Lecithinized brain-derived neurotrophic factor promotes the differentiation of embryonic stem cells in vitro and in vivo
- in-vitro, Nor, NA
*BDNF↑, *motorD↑, *Diff↑,
2242- MF,    Electromagnetic stimulation increases mitochondrial function in osteogenic cells and promotes bone fracture repair
- in-vitro, Nor, NA
*MMP↑, *Diff↑, *OXPHOS↑, *BMD↑, ATP∅,
2243- MF,    Pulsed electromagnetic fields increase osteogenetic commitment of MSCs via the mTOR pathway in TNF-α mediated inflammatory conditions: an in-vitro study
- in-vitro, Nor, NA
*eff↑, *mTOR↑, *Akt↑, *PKA↑, *MAPK↑, *ERK↑, *BMP2↑, *Diff↑, *PKCδ↓, *VEGF↑, *IL10↑,
2240- MF,    Pulsed electromagnetic field induces Ca2+-dependent osteoblastogenesis in C3H10T1/2 mesenchymal cells through the Wnt-Ca2+/Wnt-β-catenin signaling pathway
- in-vitro, Nor, C3H10T1/2
*Ca+2↑, *Diff↑, *BMD↑, *Wnt↑, *β-catenin/ZEB1↑, *eff↝,
2255- MF,    Pulsed Electromagnetic Fields Induce Skeletal Muscle Cell Repair by Sustaining the Expression of Proteins Involved in the Response to Cellular Damage and Oxidative Stress
- in-vitro, Nor, SkMC
*HSP70/HSPA5↑, *Apoptosis↓, *Inflam↓, *Trx↓, *PONs↓, *SOD2↓, *TumCG↑, *Diff↑, *HIF2a↑, *Cyt‑c↑, P21↑,
3536- MF,    Targeting Mesenchymal Stromal Cells/Pericytes (MSCs) With Pulsed Electromagnetic Field (PEMF) Has the Potential to Treat Rheumatoid Arthritis
- Review, Arthritis, NA - Review, Stroke, NA
*Inflam↓, *Diff↑, *toxicity∅, *other↑, *SOX9↑, *COL2A1↑, *NO↓, *PGE2↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *IL6↓, *IL10↑, *angioG↑, *MSCs↑, *VEGF↑, *TGF-β↑, *angioG↝, *VEGF↓, Ca+2↝,
3464- MF,    Progressive Study on the Non-thermal Effects of Magnetic Field Therapy in Oncology
- Review, Var, NA
AntiTum↑, TumCG↓, TumCCA↑, Apoptosis↑, TumAuto↑, Diff↑, angioG↓, TumMeta↓, EPR↑, ChemoSen↑, ROS↑, DNAdam↑, P53↑, Akt↓, MAPK↑, Casp9↑, VEGFR2↓, P-gp↓,
530- MF,    Low frequency sinusoidal electromagnetic fields promote the osteogenic differentiation of rat bone marrow mesenchymal stem cells by modulating miR-34b-5p/STAC2
- in-vivo, Nor, NA
*miR-34b-5p↓, *ALP↑, *RUNX2↑, *BMP2↑, *OCN↑, *OPN↑, *β-catenin/ZEB1↑, *STAC2↑, *Diff↑, *BMD↑,
4356- MF,    Pulsed electromagnetic fields synergize with graphene to enhance dental pulp stem cell-derived neurogenesis by selectively targeting TRPC1 channels
- in-vitro, Nor, NA
*Diff↑, *TRPC1↑, *ROS↑,
3535- MFrot,  MF,    Pulsed Electromagnetic Field Stimulation in Osteogenesis and Chondrogenesis: Signaling Pathways and Therapeutic Implications
- Review, Nor, NA
*eff↑, *COL2A1↑, *SOX9↑, *Ca+2↑, *FAK↑, *F-actin↑, *Inflam↓, *other↑, *Diff↑, *BMD↑,
2311- MFrot,  MF,    Magnetic fields as a potential therapy for diabetic wounds based on animal experiments and clinical trials
- in-vivo, Nor, HaCaT
*COX2↓, *Inflam↓, *MMP9↑, *GPx↑, *Diff↑,
5254- NCL,    The magic bullet: Niclosamide
- Review, Var, NA
Wnt↓, β-catenin/ZEB1↓, RAS↓, STAT3↓, NOTCH↓, E2Fs↓, mTOR↓, eff↑, PD-1↓, PD-L1↓, BioAv↝, toxicity↓, BioAv↑, ETC↑, NADH:NAD↓, TCA↑, Warburg↓, Diff↑, AMPK↑, P53↑, PP2A↑, HIF-1↓, KRAS↓, Myc↓, RadioS↑, ChemoSen↑, Dose↝, Dose↑,
2055- PB,    The Effects of Butyric Acid on the Differentiation, Proliferation, Apoptosis, and Autophagy of IPEC-J2 Cells
- in-vitro, Nor, IPEC-J2
*Diff↑, *TumCP↓, *TumCCA↑, *ROS↑, *Casp3↑, *TNF-α↑,
2064- PB,  Rad,    Phenylbutyrate Attenuates the Expression of Bcl-XL, DNA-PK, Caveolin-1, and VEGF in Prostate Cancer Cells
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145 - in-vitro, Pca, LNCaP
Bcl-xL↓, Cav1↓, VEGF↓, RadioS↑, chemoP↑, HDAC↓, *toxicity↓, Diff↑, Prot↓,
2036- PB,    Phenylbutyrate induces apoptosis in human prostate cancer and is more potent than phenylacetate
- in-vitro, Pca, NA - in-vivo, NA, NA
TumCG↓, eff↑, Diff↑,
2040- SAHA,    The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin-binding protein-2, and down-regulates thioredoxin
- in-vitro, Pca, LNCaP - in-vitro, CRC, T24/HTB-9 - in-vitro, BC, MCF-7
HDAC↓, TumCG↓, Diff↑, Apoptosis↑, TXNIP↑,
5004- Sal,    Targeting Telomerase Enhances Cytotoxicity of Salinomycin in Cancer Cells
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
eff↑, AntiCan↑, CSCs↑, Wnt↓, β-catenin/ZEB1↓, Diff↑, ROS↑, toxicity↝, selectivity↝, eff↑,
4905- Sal,    Salinomycin as a drug for targeting human cancer stem cells
- Review, Var, NA
CSCs↓, selectivity↑, Apoptosis↑, Casp3↑, ROS↑, Wnt↓, cycD1/CCND1↓, Fibronectin↓, OXPHOS↓, Diff↑, Dose↝,
5122- Sal,    Identification of selective inhibitors of cancer stem cells by high-throughput screening
- in-vivo, BC, SUM159 - NA, NA, 4T1
CSCs↓, TumCG↓, Diff↑, selectivity↑, CD44↓, CD24↓, TumVol↓,
5045- SAS,    Sulfasalazine, a potent cystine-glutamate transporter inhibitor, enhances osteogenic differentiation of canine adipose-derived stem cells
- in-vivo, Var, NA
xCT↓, GSH↓, BMPs↑, Diff↑,
2212- SK,    Shikonin Exerts an Antileukemia Effect against FLT3-ITD Mutated Acute Myeloid Leukemia Cells via Targeting FLT3 and Its Downstream Pathways
- in-vitro, AML, NA
FLT3↓, NF-kB↓, miR-155↓, Diff↑, TumCG↓,
1345- SK,    The Critical Role of Redox Homeostasis in Shikonin-Induced HL-60 Cell Differentiation via Unique Modulation of the Nrf2/ARE Pathway
- in-vitro, AML, HL-60
CD14↑, CD11b↑, ROS↑, GSH↓, GSH/GSSG↓, GPx↑, Catalase↓, Diff↑,
2132- TQ,    Thymoquinone treatment modulates the Nrf2/HO-1 signaling pathway and abrogates the inflammatory response in an animal model of lung fibrosis
- in-vivo, Nor, NA
*Weight∅, *antiOx↑, *lipid-P↓, *MMP7↓, *Casp3↓, *BAX↓, *TGF-β↓, *Diff↑, *NRF2↓, *HO-1↓, *NF-kB↓, *IκB↑,
5019- UA,    Ursolic acid in colorectal cancer: mechanisms, current status, challenges, and future research directions
- Review, Var, NA
TumCP↓, Diff↑, Apoptosis↑, TumCI↓, angioG↓,

Showing Research Papers: 1 to 31 of 31

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 31

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Catalase↓, 1,   Ferroptosis↑, 1,   GPx↑, 1,   GSH↓, 2,   GSH/GSSG↓, 1,   HO-1↓, 1,   lipid-P↑, 1,   NRF2∅, 1,   OXPHOS↓, 1,   ROS↓, 1,   ROS↑, 7,   mt-ROS↑, 1,   TrxR↓, 1,   xCT↓, 1,  

Metal & Cofactor Biology ⓘ

Ferritin↓, 1,   Tf↑, 1,  

Mitochondria & Bioenergetics ⓘ

ATP∅, 1,   ETC↑, 1,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 2,   Cav1↓, 1,   NADH:NAD↓, 1,   SIRT1↑, 1,   TCA↑, 1,   Warburg↓, 1,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↑, 7,   Bcl-xL↓, 1,   Casp3↑, 1,   Casp9↑, 1,   Ferroptosis↑, 1,   MAPK↑, 1,   Myc↓, 1,   survivin↓, 1,  

Transcription & Epigenetics ⓘ

Prot↓, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 2,  

DNA Damage & Repair ⓘ

DNAdam↑, 3,   P53↑, 2,  

Cell Cycle & Senescence ⓘ

CDK1↑, 1,   CDK2↑, 1,   CDK4↑, 1,   cycD1/CCND1↓, 1,   E2Fs↓, 1,   P21↑, 1,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State ⓘ

CD133↓, 1,   CD24↓, 1,   CD44↓, 1,   CSCs↓, 2,   CSCs↑, 1,   Diff↑, 18,   FLT3↓, 1,   HDAC↓, 3,   HDAC8↓, 1,   mTOR↓, 1,   mTOR↑, 1,   NOTCH↓, 1,   RAS↓, 1,   STAT3↓, 1,   TumCG↓, 7,   VGCC↑, 1,   VGSC↑, 1,   Wnt↓, 3,  

Migration ⓘ

Ca+2↑, 1,   Ca+2↝, 1,   CD11b↑, 1,   Fibronectin↓, 1,   Ki-67↓, 1,   KRAS↓, 1,   miR-155↓, 1,   TumCI↓, 3,   TumCMig↓, 2,   TumCP↓, 3,   TumMeta↓, 1,   TXNIP↑, 1,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature ⓘ

angioG↓, 4,   EPR↑, 1,   HIF-1↓, 1,   VEGF↓, 1,   VEGFR2↓, 1,  

Barriers & Transport ⓘ

BBB↑, 1,   CellMemb↑, 1,   P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

CD14↑, 1,   COX2↓, 1,   IL1β↓, 1,   NF-kB↓, 1,   PD-1↓, 1,   PD-L1↓, 1,  

Protein Aggregation ⓘ

PP2A↑, 1,  

Hormonal & Nuclear Receptors ⓘ

CDK6↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   BioAv↝, 1,   ChemoSen↑, 4,   Dose↑, 1,   Dose↝, 4,   eff↑, 4,   RadioS↑, 5,   selectivity↑, 4,   selectivity↝, 1,  

Clinical Biomarkers ⓘ

BMPs↑, 1,   Ferritin↓, 1,   Ki-67↓, 1,   KRAS↓, 1,   Myc↓, 1,   PD-L1↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   AntiTum↑, 1,   chemoP↑, 1,   OS↑, 1,   toxicity↓, 2,   toxicity↝, 1,   TumVol↓, 1,   Wound Healing↑, 1,  
Total Targets: 114

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   GPx↑, 1,   HO-1↓, 1,   lipid-P↓, 1,   NRF2↓, 1,   OXPHOS↑, 1,   ROS↑, 2,   SOD2↓, 1,   Trx↓, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↑, 1,  

Core Metabolism/Glycolysis ⓘ

PONs↓, 1,  

Cell Death ⓘ

Akt↑, 1,   Apoptosis↓, 1,   BAX↓, 1,   BMP2↑, 2,   Casp3↓, 1,   Casp3↑, 1,   Cyt‑c↑, 1,   MAPK↑, 1,  

Kinase & Signal Transduction ⓘ

OCN↑, 1,   SOX9↑, 2,  

Transcription & Epigenetics ⓘ

other↑, 2,  

Protein Folding & ER Stress ⓘ

HSP70/HSPA5↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

Diff↑, 13,   ERK↑, 1,   MSCs↑, 1,   mTOR↑, 1,   RUNX2↑, 1,   TumCG↑, 1,   Wnt↑, 1,  

Migration ⓘ

Ca+2↑, 2,   COL2A1↑, 2,   F-actin↑, 1,   FAK↑, 1,   MMP7↓, 1,   MMP9↑, 1,   OPN↑, 1,   PKA↑, 1,   PKCδ↓, 1,   STAC2↑, 1,   TGF-β↓, 1,   TGF-β↑, 1,   TRPC1↑, 1,   TumCP↓, 1,   β-catenin/ZEB1↑, 2,  

Angiogenesis & Vasculature ⓘ

angioG↑, 1,   angioG↝, 1,   HIF2a↑, 1,   miR-34b-5p↓, 1,   NO↓, 1,   VEGF↓, 1,   VEGF↑, 2,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   IL10↑, 2,   IL1β↓, 1,   IL6↓, 1,   Inflam↓, 4,   IκB↑, 1,   NF-kB↓, 2,   PGE2↓, 1,   TNF-α↓, 1,   TNF-α↑, 1,  

Synaptic & Neurotransmission ⓘ

BDNF↑, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 3,   eff↝, 1,  

Clinical Biomarkers ⓘ

ALP↑, 1,   BMD↑, 4,   IL6↓, 1,  

Functional Outcomes ⓘ

motorD↑, 1,   toxicity↓, 2,   toxicity∅, 1,   Weight∅, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 1,   Inf↓, 1,  
Total Targets: 75

Scientific Paper Hit Count for: Diff, differentiation
10 Magnetic Fields
3 Phenylbutyrate
3 salinomycin
2 Artemisinin
2 Magnetic Field Rotating
2 Shikonin
1 Auranofin
1 Silver-NanoParticles
1 Chrysin
1 Electrical Pulses
1 Hydrogen Gas
1 Lecithin
1 Niclosamide (Niclocide)
1 Radiotherapy/Radiation
1 Vorinostat
1 Sulfasalazine
1 Thymoquinone
1 Ursolic acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1235  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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