BMAL1 Cancer Research Results

BMAL1, ARNTL: Click to Expand ⟱
Source:
Type:
BMAL1 (Brain and Muscle ARNT-Like 1), also known as ARNTL, is a core component of the circadian clock machinery. It regulates daily rhythmicity in gene expression, metabolism, cell cycle, and DNA repair mechanisms.

-BMAL1 is emerging as an important factor in cancer biology through its regulation of circadian rhythms, metabolism, and the cell cycle. Altered BMAL1 expression or disrupted oscillatory patterns have been associated with more aggressive tumors and poorer prognosis in several cancer types, including breast, colorectal, lung, and liver cancers.
Scientific Papers found: Click to Expand⟱
2071- HNK,    Identification of senescence rejuvenation mechanism of Magnolia officinalis extract including honokiol as a core ingredient
- Review, Nor, HaCaT
*ROS↓, Magnolia officinalis (M. officinalis) extract significantly lowered the levels of ROS in senescent fibroblasts.
*antiOx↑, honokiol was demonstrated as a core ingredient of M. officinalis extract that exhibits antioxidant effects.
*AntiAge↑, new approaches to anti–aging treatments
*MMP↑, increases MMP
*ECAR↓, senescent fibroblasts treated with M. officinalis extract had lower ECAR values than those treated with DMSO, suggesting that M. officinalis treatment lowed glycolysis rate
*Glycolysis↓, honokiol, similar to M. officinalis, reduced the dependence of glycolysis as an energy source, indicating restoration of mitochondrial function by honokiol.
*PAR-2↓, downregulation of PAR–2 expression by M. officinalis may reduce skin pigmentation.
*CXCL12↑, upregulation of SDF–1 expression by M. officinalis may reduce skin pigmentation.
*BMAL1↑, activation of Bmal–1 expression by M. officinalis promote skin turnover.
*mt-ROS↓, compared to M. officinalis extract, honokiol at 1 and 10 μM was more effective in lowering mitochondrial ROS levels
*OXPHOS↓, Inhibition of oxidative phosphorylation and induction of a compensatory shift toward glycolysis resulted in lower compensatory glycolysis in honokiol–treated senescent fibroblasts


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   OXPHOS↓, 1,   ROS↓, 1,   mt-ROS↓, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↑, 1,  

Core Metabolism/Glycolysis ⓘ

BMAL1↑, 1,   ECAR↓, 1,   Glycolysis↓, 1,  

Migration ⓘ

CXCL12↑, 1,  

Immune & Inflammatory Signaling ⓘ

PAR-2↓, 1,  

Functional Outcomes ⓘ

AntiAge↑, 1,  
Total Targets: 11

Scientific Paper Hit Count for: BMAL1, ARNTL
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1248  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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