creat Cancer Research Results

creat, creatinine: Click to Expand ⟱
Source:
Type:
Creatinine is fundamentally a metabolic waste product derived from creatine phosphate in muscle. Its blood levels are routinely used as a clinical biomarker to assess kidney function rather than a direct regulator of oncogenic processes.
Creatinine is a primary marker used to estimate the glomerular filtration rate (GFR).

-Elevated creatinine can be a sign of compromised kidney vascular function.
Scientific Papers found: Click to Expand⟱
7113- GEO2,    Nephrotoxicity and neurotoxicity in humans from organogermanium compounds and germanium dioxide
- Review, Nor, NA
*Dose↓, The estimated average dietary intake of Ge in humans is 1.5 mg/d. Ge is widely distributed in edible foods, all of which, with few exceptions, contain less than 5 ppm Ge, since higher levels are toxic to most plants
*Dose↑, germanium sesquioxide (Ge-132) and lactate-citrate-germanate (Ge lactate citrate) have been sold as "nutritional supplements" in some countries for their purported immunomodulatory effects or as health-producing elixirs, resulting in intakes of Ge si
*toxicity↑, Since 1982, there have been 18 reported cases of acute renal dysfunction or failure, including two deaths, linked to oral intake of Ge elixirs containing germanium dioxide (GeO2) or Ge-132.
*creat↑, Serum creatinine levels have been well above 400 mumol/L in such patients
*Dose↑, In 17 of 18 cases, accumulated elemental Ge intakes reportedly ranged between 16 to 328 g over a 4-36 mo period, or between 100 to 2000 times the average estimated dietary intake for human.
*other?, It is recommended that patients exposed to long-term (greater than 3 mo) Ge supplementation at levels well above the estimated daily intake be medically supervised and monitored for potential renal-, pulmonary- or neurotoxicity.

7121- GEO2,    Subacute nephrotoxicity of germanium dioxide in the experimental animal
- in-vivo, Nor, NA
toxicity↑, Recently, patients with persistent renal damage after chronic ingestion of germanium dioxide (GeO2)-containing compounds have been reported in Japan.
*creat↑, Renal dysfunction was demonstrated by the increased serum creatinine, BUN, and serum phosphate and decreased creatinine clearance.
*BUN↑,
*other↑, Liver dysfunction was observed as demonstrated by the increased GOT and GPT, and hypoproteinemia by the decreased total protein and albumin in the GeO2 group


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Functional Outcomes(tgid=23) ⓘ

toxicity↑, 1,  
Total Targets: 1

Pathway results for Effect on Normal Cells:


Core Metabolism/Glycolysis(tgid=4) ⓘ

BUN↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other?, 1,   other↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↓, 1,   Dose↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

creat↑, 2,  

Functional Outcomes(tgid=23) ⓘ

toxicity↑, 1,  
Total Targets: 7

Scientific Paper Hit Count for: creat, creatinine
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1251  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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