Mst1 Cancer Research Results

Mst1, Mammalian Ste20-like kinase 1: Click to Expand ⟱
Source:
Type:
MST1 (Mammalian Ste20-like kinase 1), also known as STK4, is a key component of the Hippo signaling pathway and has been implicated in regulating cell proliferation, apoptosis, and tissue homeostasis.

Several studies have suggested that MST1 expression may be reduced in aggressive breast cancer subtypes.

• Prognosis: Lower MST1 levels have been associated with enhanced tumor growth and metastasis, suggesting a potential tumor suppressor role. Some reports correlate low MST1 with poorer disease-free and overall survival.
Scientific Papers found: Click to Expand⟱
7375- RS,    Regulation of hippo signaling mediated apoptosis by Rauvolfia tetraphylla in triple-negative breast cancer
- in-vitro, BC, MDA-MB-231
eff↝, Our study imparts that RTE and RTC2 showed promising cytotoxic effects compared to RTC1.
TumCCA↑, The result shows around 80% of cells were observed in the G0/G1 phase in cell cycle analysis indicating the cell cycle inhibition and duel staining clearly showed the apoptotic effect.
TumCMig↓, The migration of cells after the scratch was 60.45% observed in control and 90% in treated cells showing the inhibition of migration.
ROS↑, ROS distribution was intense compared to control indicating the increased ROS stress in treated cells.
BAX↑, Both RTE and RTC2-treated cells showed the potential to suppress proliferation and induce apoptotic change by upregulating BAX and MST-1
Mst1↑,
Bcl-2↓, and suppressing Bcl2, LATS-1, and YAP
YAP/TEAD↓,
LATS1↓,


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

LATS1↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Cell Death(tgid=5) ⓘ

BAX↑, 1,   Bcl-2↓, 1,   YAP/TEAD↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Mst1↑, 1,  

Migration(tgid=13) ⓘ

TumCMig↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↝, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Mst1, Mammalian Ste20-like kinase 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1266  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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