PIP3 Cancer Research Results

PIP3, Phosphatidylinositol (3,4,5)-trisphosphate: Click to Expand ⟱
Source:
Type:
PIP3 is a key lipid second messenger that plays a central role in the PI3K/AKT signaling pathway.

– Increased PIP3 levels are a hallmark of cancers characterized by PI3K pathway activation.

– Mutations or amplifications in PI3K subunits and loss of PTEN function often result in sustained PIP3 production, thereby driving oncogenic processes.

– Elevated PIP3 signaling contributes to increased cell proliferation, survival, metabolic reprogramming, and metastatic potential.
Scientific Papers found: Click to Expand⟱
2269- dietMet,    Mechanisms of Increased In Vivo Insulin Sensitivity by Dietary Methionine Restriction in Mice
- in-vivo, Nor, NA
*adiP↑, metabolic responses include reduced adiposity, reduced circulating and tissue lipid levels, increased plasma adiponectin and fibroblast growth factor 21 (FGF-21), and reduced fasting insulin and blood glucose
*FGF↑,
*Insulin↓,
*glucose↓,
*Akt↑, activation of Akt was significantly higher in methionine-restricted HepG2 cells
*GSH↓, MR produces a significant decrease in hepatic GSH
*PTEN↓, MR in HepG2 cells limits the capacity of the cells to reactivate oxidized PTEN, resulting in amplification of insulin activation of Akt by increasing PIP3.
*FGF21↑, MR produced a threefold increase in FGF-21 mRNA that was mirrored by a fourfold increase in serum FGF-21.
*PIP3↑,


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

GSH↓, 1,  

Mitochondria & Bioenergetics ⓘ

Insulin↓, 1,  

Core Metabolism/Glycolysis ⓘ

adiP↑, 1,   FGF21↑, 1,   glucose↓, 1,   PIP3↑, 1,  

Cell Death ⓘ

Akt↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

FGF↑, 1,   PTEN↓, 1,  
Total Targets: 9

Scientific Paper Hit Count for: PIP3, Phosphatidylinositol (3,4,5)-trisphosphate
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1280  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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