NOX Cancer Research Results

NOX, NADPH oxidase: Click to Expand ⟱
Source:
Type:
NOX refers to the NADPH oxidase (NOX) family of enzymes, which generates reactive oxygen species (ROS) by transferring electrons from NADPH to molecular oxygen. Several NOX isoforms (e.g., NOX1, NOX2, NOX4, etc.) have been implicated in cancer biology.

-NOX1 and NOX4 are frequently found to be upregulated in colorectal, prostate, and pancreatic cancers, while NOX2 is associated with cells in the tumor microenvironment (like macrophages).
Scientific Papers found: Click to Expand⟱
6735- Dipy,    Dipyridamole Reverses Peripheral Ischemia and Induces Angiogenesis in the Db/Db Diabetic Mouse Hind Limb Model by Decreasing Oxidative Stress
- in-vivo, Nor, NA
*AntiAg↑, Dipyridamole anti-platelet therapy has previously been suggested to ameliorate chronic tissue ischemia in healthy animals.
*BloodF↑, Restoration of ischemic tissue blood flow was associated with increased vascular density and endothelial cell proliferation observed only in ischemic limbs.
*NOX↑, Dipyridamole significantly increased total nitric oxide metabolite levels (NOx) in tissue that were not associated with changes in eNOS expression or phosphorylation.
*antiOx↑, importance of dipyridamole antioxidant activity in restoring tissue NO bioavailability during diabetes.
*NO↑,

2833- FIS,  AgNPs,    Glucose-capped fisetin silver nanoparticles induced cytotoxicity and ferroptosis in breast cancer cells: A molecular perspective
- in-vitro, BC, MDA-MB-231
MMP↓, MDA-MB-231 cells treated with glucose-capped fisetin silver nanoparticles showed signs of apoptosis, decreased mitochondrial membrane potential, and elevated Reactive oxygen species (ROS) production.
ROS↑,
NRF2↑, upregulation of SLC7A11, SLC40A1, NRF2F, NOX2, and NOX5 genes that are associated with various crucial cellular events
NOX↑,
selectivity↑, Glucose nanoparticles selectively deliver cytotoxic agents to cancer cells by targeting the glucose transporters overexpressed in cancer cells, resulting in minimal toxicity to healthy tissues


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

NRF2↑, 1,   ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

NOX↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

selectivity↑, 1,  
Total Targets: 5

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

NOX↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BloodF↑, 1,  
Total Targets: 5

Scientific Paper Hit Count for: NOX, NADPH oxidase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1309  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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