CDC2 Cancer Research Results

CDC2, cell division cycle 2: Click to Expand ⟱
Source:
Type:
CDC2 is a gene that encodes a protein known as cyclin-dependent kinase 1 (CDK1), a critical regulator of the cell cycle. CDK1 (historically referred to as CDC2 in some contexts) plays a central role in controlling the transition from the G₂ phase to mitosis (M phase).
Scientific Papers found: Click to Expand⟱
3162- Ash,    Molecular insights into cancer therapeutic effects of the dietary medicinal phytochemical withaferin A
- Review, Var, NA
lipid-P↓, SOD↑, GPx↑, P53↑, Bcl-2↑, E6↓, E7↓, pRB↑, CycB/CCNB1↑, CDC2↑, P21↑, PCNA↓, ALDH1A1↓, Vim↓, Glycolysis↓, cMyc↓, BAX↑, NF-kB↓, Casp3↑, CHOP↑, DR5↑, ERK↓, Wnt↓, β-catenin/ZEB1↓, Akt↓, HSP90↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

GPx↑, 1,   lipid-P↓, 1,   SOD↑, 1,  

Mitochondria & Bioenergetics ⓘ

CDC2↑, 1,  

Core Metabolism/Glycolysis ⓘ

cMyc↓, 1,   Glycolysis↓, 1,  

Cell Death ⓘ

Akt↓, 1,   BAX↑, 1,   Bcl-2↑, 1,   Casp3↑, 1,   DR5↑, 1,  

Transcription & Epigenetics ⓘ

pRB↑, 1,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   HSP90↓, 1,  

DNA Damage & Repair ⓘ

P53↑, 1,   PCNA↓, 1,  

Cell Cycle & Senescence ⓘ

CycB/CCNB1↑, 1,   P21↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

ALDH1A1↓, 1,   ERK↓, 1,   Wnt↓, 1,  

Migration ⓘ

Vim↓, 1,   β-catenin/ZEB1↓, 1,  

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 1,  

Clinical Biomarkers ⓘ

E6↓, 1,   E7↓, 1,  
Total Targets: 26

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: CDC2, cell division cycle 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1323  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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