AQPs Cancer Research Results

AQPs, Aquaporins: Click to Expand ⟱
Source:
Type:
Aquaporins are membrane proteins that form channels to facilitate water transport across cell membranes. They are essential for maintaining water homeostasis in various tissues, and research over the past decade has revealed their involvement in several aspects of cancer biology.
• Aquaporins can influence cell proliferation. Some studies have shown that overexpression of specific aquaporin isoforms (like AQP1, AQP3, and AQP5) is associated with increased cell proliferation in different cancer types.
-increased expression of AQP1 or AQP3 has been correlated with poor prognosis in some cancers.
Scientific Papers found: Click to Expand⟱
3882- Api,    Enhancing Amyloid-β Clearance May Improve Brain Function in Alzheimer Disease
- Review, AD, NA
*AQPs↑, apigenin and sulphaquinoxaline may enhance AQP4 read-through, thereby increasing Aβ clearance.
*Aβ↓,

6929- FLS,  AudGS,    Multisensory gamma stimulation promotes glymphatic clearance of amyloid
- in-vivo, AD, NA
*pol-AQPs↑, Influx of cerebrospinal fluid was associated with increased aquaporin-4 polarization along astrocytic endfeet and dilated meningeal lymphatic vessels.
*Aβ↓, Our findings establish novel mechanisms that recruit the glymphatic system to remove brain amyloid.
*GlyFlow↑,

6930- FLS,    40 Hz light flickering facilitates the glymphatic flow via adenosine signaling in mice
*GlyFlow↑, 40 Hz light flickering enhanced glymphatic influx and efflux independently of anesthesia and sleep,
*e-ADO↑, First, brief 40 Hz light flickering produces a robust and sustained increase in the extracellular adenosine levels in the primary visual cortex and other brain regions
*Sleep↑, Second, 40 Hz light flickering promotes sleep18, when the glymphatic system is mostly active
*Dose↝, 30-min exposure to light flickering (white light, illuminance of 3000 lux, irradiance of 1.10 mW/cm2 at 20 cm distance, 50% duty cycle) at 40 Hz
*AQPs↑, Accordingly, we found that 40 Hz light flickering increased the gene expression of AQP4-M23
BloodF↑, 40 Hz light flickering increases vasomotion and cerebral blood flow (CBF)

6943- FLS,    Promoting glymphatic flow: A non-invasive strategy using 40 Hz light flickering
- Review, AD, NA
*GlyFlow↑, Previous studies have uncovered that 40 Hz flickering augmented glymphatic flow and facilitated sleep
*Sleep↑,
*AQPs↑, by promoting the polarization of astrocytic aquaporin-4 (AQP4) and vasomotion through upregulated adenosine-A2A receptor (A2AR) signaling, independent of sleep.
*neuroP↑, presenting a potential strategy for neurodegenerative disease treatment.


Showing Research Papers: 1 to 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Clinical Biomarkers(tgid=22) ⓘ

BloodF↑, 1,  
Total Targets: 1

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

e-ADO↑, 1,   GlyFlow↑, 3,  

Barriers & Transport(tgid=15) ⓘ

AQPs↑, 3,   pol-AQPs↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  

Functional Outcomes(tgid=23) ⓘ

neuroP↑, 1,   Sleep↑, 2,  
Total Targets: 8

Scientific Paper Hit Count for: AQPs, Aquaporins
3 Flickering Light Stimulation
1 Apigenin (mainly Parsley)
1 Auditory Gamma Stimulation / 40 Hz Auditory Stimulation
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1324  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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