Aβ Cancer Research Results
Aβ, Aβ aggregation: Click to Expand ⟱
| Source: |
| Type: |
Beta-Amyloid (Aβ): In Alzheimer’s disease, Aβ peptides tend to misfold and aggregate into oligomers and fibrils.
|
Scientific Papers found: Click to Expand⟱
*Aβ↑, Oleuropein-based studies reported inhibition of amyloid-β and α-synuclein aggregation with behavioural improvements.
*cognitive↑, Hydroxytyrosol primarily exerted antioxidant and anti-inflammatory effects with modest cognitive benefits
*antiOx↑,
*Inflam↓,
*neuroP↑, Olive biophenols demonstrate consistent neuroprotective effects in preclinical models;
| - |
Review, |
AD, |
NA |
|
|
|
- |
Review, |
Park, |
NA |
|
|
|
*Inflam↓, Aromatic plants, sage (Salvia officinalis), lavender (Lavandula angustifolia), and rosemary (Salvia Rosmarinus) have already shown anxiolytics, anti-inflammatory, antioxidant, and neuroprotective effects.
*antiOx↑,
*neuroP↑,
*ERK↑, exert neuroprotective effects mainly through increasing neurotransmitters and antioxidants, activating ERK/CREB/BDNF pathway, and inhibition of β-amyloid, pro-inflammatory cytokines, and Acetylcholine esterase (AChE) activity.
*CREB↑,
*BDNF↑,
*Aβ↑,
*AChE↓,
*memory↑, Rosmarinus officinalis led to improvement in long-term memory and cognitive responses in rats, through the inhibition of acetylcholinesterase (AChE) activity
*cognitive↑,
| - |
Study, |
AD, |
NA |
|
|
|
- |
Study, |
Park, |
NA |
|
|
|
*Risk↓, Pantothenic acid was significantly decreased in the cerebellum (p = 0.008), substantia nigra (p = 0.02), and medulla (p = 0.008) of PDD cases.
*other↝, These findings have raised the question as to whether there may be common pathogenic insults present across multiple neurodegenerative diseases contributing to these similarities in presentation
*other↝, including widespread urea [12,13,14,15] and glucose increases [13,16,17,18], dysregulation of glucose and purine metabolism pathways [13,16,17,19,20], and decreases in the essential nutrient pantothenic acid [21,22], also known as vitamin B5.
*Ach↑, Pantothenic acid is essential for the synthesis of coenzyme A (CoA), a molecule with extensive roles in metabolism including in the tricarboxylic acid (TCA) cycle, fatty acid metabolism, and acetylcholine and myelin synthesis,
*Aβ↑, Interestingly though, an increased dietary intake of pantothenic acid has been associated with increased amyloid-β burden in individuals with cognitive impairment
*other?, This may indicate that pantothenic acid deficiencies in the brain cannot be counteracted by an increased dietary intake.
Showing Research Papers: 1 to 3 of 3
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3
Pathway results for Effect on Cancer / Diseased Cells:
Total Targets: 0
Pathway results for Effect on Normal Cells:
Redox & Oxidative Stress(tgid=1) ⓘ
antiOx↑, 2,
Core Metabolism/Glycolysis(tgid=4) ⓘ
CREB↑, 1,
Transcription & Epigenetics(tgid=7) ⓘ
Ach↑, 1, other?, 1, other↝, 2,
Proliferation, Differentiation & Cell State(tgid=12) ⓘ
ERK↑, 1,
Immune & Inflammatory Signaling(tgid=16) ⓘ
Inflam↓, 2,
Synaptic & Neurotransmission(tgid=18) ⓘ
AChE↓, 1, BDNF↑, 1,
Protein Aggregation(tgid=19) ⓘ
Aβ↑, 3,
Functional Outcomes(tgid=23) ⓘ
cognitive↑, 2, memory↑, 1, neuroP↑, 2, Risk↓, 1,
Total Targets: 14
Scientific Paper Hit Count for: Aβ, Aβ aggregation
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:1333 State#:% Dir#:2
wNotes=on sortOrder:rid,rpid
Home Page