GPx3 Cancer Research Results

GPx3, Glutathione Peroxidase 3: Click to Expand ⟱
Source:
Type:
GPX3, or Glutathione Peroxidase 3, is an enzyme that plays a crucial role in protecting cells from oxidative stress by reducing hydrogen peroxide and other peroxides.
Glutathione peroxidase 3 (GPX3) is another member of the glutathione peroxidase family, primarily found in extracellular spaces and secreted into the bloodstream. It plays a crucial role in protecting cells from oxidative stress by reducing hydrogen peroxide and organic peroxides.
GPX3 can act as a tumor suppressor, as its expression is often downregulated in various types of cancer, including breast, prostate, and colorectal cancers. Lower levels of GPX3 may lead to increased oxidative stress, which can promote cancer cell proliferation and survival.
Conversely, in some contexts, GPX3 may also be associated with cancer progression, particularly in the tumor microenvironment, where it can influence the behavior of cancer cells and their interactions with surrounding tissues.

GPX3 expression is often decreased in various cancers and is generally associated with poorer prognosis due to its role in protecting cells from oxidative stress. The downregulation of GPX3 can lead to increased oxidative damage, promoting tumor progression and aggressiveness.


Scientific Papers found: Click to Expand⟱
4111- MF,    Coupling of pulsed electromagnetic fields (PEMF) therapy to molecular grounds of the cell
- Review, Arthritis, NA
*Inflam↓, ultimately lead to a dampening of inflammatory signals like interleukins
*Cartilage↑, this therapy has positive effects for the regeneration of musculoskeletal tissues such as cartilage, bone, tendon and ligament
*Pain↓, Ryang We et al. [18] found a significant beneficial effect of PEMF on WOMAC pain scores at 1 month compared with a sham treatment
*QoL↑, significant improvements in mobility, daily activity score as well as global score during treatment of acute osteoarthritis of knee joint
*Dose↝, PEMF stimulation (38 Hz, 2 mT) for 2 h per day enhanced osteoblastic functions through amelioration of the cytoskeletal organization;
*VEGF↑, increase of anti-inflammatory prostaglandins, and a huge rise in the Vascular Endothelial Growth Factor (VEGF)-A-mRNA transcription.
*NO↑, stimulatory effect of PEMF on osteoblast proliferation and differentiation is accompanied by an increase in nitric oxide (NO) synthesis
*TGF-β↑, Transforming Growth Factor (TGF-β) family is enhanced by PEMF[67] and local expression of TGF-β results in improved bone fracture healing
*MMP9↓, PEMF treatment suppressed IL-1β-mediated up-regulation of MMP-9 protein levels.
*PGE2↑, Sontag and Dertinger [97] investigated the liberation of prostaglandin E2 (PGE2) during application of EMF of different frequencies: here “windows” at 6 and 16 Hz were found, where PGE was 200% above 0 Hz baseline.
*GPx3↑, PEMF exposure also induced expression of GPX3, SOD2, CAT and GSR on mRNA, protein and enzyme activity level
*SOD2↑,
*Catalase↑,
*GSR↑,
*Ca+2↑, many EMF-effect studies is a direct action on voltage-gated calcium channels (VGCCs) (Figure 1). This is normally accompanied by a rapid increase of Ca2+


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

Catalase↑, 1,   GPx3↑, 1,   GSR↑, 1,   SOD2↑, 1,  

Migration ⓘ

Ca+2↑, 1,   Cartilage↑, 1,   MMP9↓, 1,   TGF-β↑, 1,  

Angiogenesis & Vasculature ⓘ

NO↑, 1,   VEGF↑, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,   PGE2↑, 1,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,  

Functional Outcomes ⓘ

Pain↓, 1,   QoL↑, 1,  
Total Targets: 15

Scientific Paper Hit Count for: GPx3, Glutathione Peroxidase 3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:134  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

Home Page