BACE Cancer Research Results

BACE, β-site APP-cleaving enzyme: Click to Expand ⟱
Source:
Type:
BACE stands for β-site APP-cleaving enzyme, also known as β-secretase. It plays a central role in the pathogenesis of Alzheimer’s disease by initiating the production of amyloid-β (Aβ) peptides, the primary components of amyloid plaques found in the brains of individuals with AD.
-inhibiting BACE1 reduces Aβ production.
Scientific Papers found: Click to Expand⟱
3736- RF,    Long-term electromagnetic pulse exposure induces Abeta deposition and cognitive dysfunction through oxidative stress and overexpression of APP and BACE1
- in-vivo, AD, NA
*cognitive↓, We found that long-term EMP exposure induced cognitive damage in rats.
*BACE↑, BACE1) and microtubule-associated protein 1 light chain 3-II (LC3-II) in EMP-exposed rats hippocampus were also higher than that of sham-exposed rats.

4870- Uro,    Urolithin A attenuates memory impairment and neuroinflammation in APP/PS1 mice
- in-vivo, AD, NA
*cognitive↑, UA ameliorated cognitive impairment, prevented neuronal apoptosis, and enhanced neurogenesis in APP/PS1 mice.
*Apoptosis↓,
*neuroP↑,
*Aβ↓, UA attenuated Aβ deposition and peri-plaque microgliosis and astrocytosis in the cortex and hippocampus.
*AMPK↑, enhancing cerebral AMPK activation, decreasing the activation of P65NF-κB and P38MAPK, and suppressing Bace1 and APP degradation.
*NF-kB↓,
*MAPK↓,
*BACE↑,
*neuroG↑, triggering neurogenesis via anti-inflammatory signaling in APP/PS1 mice,
*Inflam↓,
*memory↑, UA ameliorates learning and memory deficits in APP/PS1 mice


Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Core Metabolism/Glycolysis ⓘ

AMPK↑, 1,  

Cell Death ⓘ

Apoptosis↓, 1,   MAPK↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

neuroG↑, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,   NF-kB↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 1,   BACE↑, 2,  

Functional Outcomes ⓘ

cognitive↓, 1,   cognitive↑, 1,   memory↑, 1,   neuroP↑, 1,  
Total Targets: 12

Scientific Paper Hit Count for: BACE, β-site APP-cleaving enzyme
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1349  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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