BACE/β-secretase Cancer Research Results

BACE/β-secretase, β-site APP-cleaving enzyme: Click to Expand ⟱
Source:
Type:
BACE stands for β-site APP-cleaving enzyme, also known as β-secretase. It plays a central role in the pathogenesis of Alzheimer’s disease by initiating the production of amyloid-β (Aβ) peptides, the primary components of amyloid plaques found in the brains of individuals with AD.
-inhibiting BACE1 reduces Aβ production.

BACE1 - Beta-Site APP Cleaving Enzyme 1 / β-Secretase 1

Abbreviation: BACE1, β-secretase, β-secretase 1

Type: Aspartyl protease / amyloidogenic APP-processing enzyme

Function: BACE1 is a membrane-associated aspartyl protease that performs the initial β-secretase cleavage of amyloid precursor protein (APP). This cleavage generates soluble APPβ and the membrane-bound C99 fragment, which is subsequently cleaved by γ-secretase to produce amyloid-β peptides including Aβ40 and Aβ42.

Alzheimer's Disease: ↑ Increased BACE1 expression or enzymatic activity promotes amyloidogenic APP processing and increases amyloid-β production. Elevated BACE1 activity has been reported in Alzheimer's disease and contributes to Aβ accumulation, plaque formation, synaptic dysfunction, and disease progression. BACE1 inhibition reduces Aβ production, although clinical BACE1 inhibitors have been limited by adverse effects related to the enzyme's normal physiological functions.
Scientific Papers found: Click to Expand⟱
7498- H2S,    Hydrogen sulfide down-regulates BACE1 and PS1 via activating PI3K/Akt pathway in the brain of APP/PS1 transgenic mouse
- in-vivo, AD, NA
*BACE/β-secretase↑, After intraperitoneal administration of an H2S donor (NaHS) into APP/PS1 mice, the levels of BACE1, PS1 and pp38MAPK were reduced and ADAM17 increased.
*ADAM17↑,
*PSEN1/PS1↓, H2S inhibits the expression of BACE1 and PS1 by activating PI3K/Akt pathway in AD.
*PI3K↑,
*Akt↑,

3736- RF,    Long-term electromagnetic pulse exposure induces Abeta deposition and cognitive dysfunction through oxidative stress and overexpression of APP and BACE1
- in-vivo, AD, NA
*cognitive↓, We found that long-term EMP exposure induced cognitive damage in rats.
*BACE/β-secretase↑, BACE1) and microtubule-associated protein 1 light chain 3-II (LC3-II) in EMP-exposed rats hippocampus were also higher than that of sham-exposed rats.

4870- Uro,    Urolithin A attenuates memory impairment and neuroinflammation in APP/PS1 mice
- in-vivo, AD, NA
*cognitive↑, UA ameliorated cognitive impairment, prevented neuronal apoptosis, and enhanced neurogenesis in APP/PS1 mice.
*Apoptosis↓,
*neuroP↑,
*Aβ↓, UA attenuated Aβ deposition and peri-plaque microgliosis and astrocytosis in the cortex and hippocampus.
*AMPK↑, enhancing cerebral AMPK activation, decreasing the activation of P65NF-κB and P38MAPK, and suppressing Bace1 and APP degradation.
*NF-kB↓,
*MAPK↓,
*BACE/β-secretase↑,
*neuroG↑, triggering neurogenesis via anti-inflammatory signaling in APP/PS1 mice,
*Inflam↓,
*memory↑, UA ameliorates learning and memory deficits in APP/PS1 mice


Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

PSEN1/PS1↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↑, 1,   Apoptosis↓, 1,   MAPK↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

neuroG↑, 1,   PI3K↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,   NF-kB↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

ADAM17↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   BACE/β-secretase↑, 3,  

Functional Outcomes(tgid=23) ⓘ

cognitive↓, 1,   cognitive↑, 1,   memory↑, 1,   neuroP↑, 1,  
Total Targets: 16

Scientific Paper Hit Count for: BACE/β-secretase, β-site APP-cleaving enzyme
1 hydrogen sulfide
1 EMF
1 Urolithin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1349  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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