monoA Cancer Research Results

monoA, monoamines: Click to Expand ⟱
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Monoamines are neurotransmitters that include dopamine (DA), serotonin (5-HT), norepinephrine (NE), epinephrine (E), and histamine. They play critical roles in mood regulation, cognition, and autonomic functions.
-Decreased serotonin levels are observed in Alzheimer’s Disease AD brains.
Scientific Papers found: Click to Expand⟱
3627- Cro,    The effects of Crocus sativus (saffron) and its constituents on nervous system: A review
- Review, AD, NA - Review, Stroke, NA
*other↑, anti-Alzheimer properties of saffron extract were shown in human and animal studies.
*monoA↑, increased glutamate and dopamine levels in the brain in a dose-dependent manner.
*Aβ↓, C. sativus stigmas has good antioxidant properties -higher than those of carrot and tomato- in a concentration and time-dependent manner which was accompanied by inhibition of Aβ fibrillogenesis.
*AChE↓, saffron extract had a moderate (up to 30 %) inhibitory activity on acetyl-cholinesterase (AChE)
*cognitive↑, results showed that the cognitive functions in saffron-treated group were significantly better than placebo
*neuroP↑, Neuroprotective effects of seven-day administration of crocetin
*lipid-P↓, crocin 10 μM inhibited the formation of peroxidized lipids in cultured PC12 cells, moderately restored superoxide dismutase (SOD) activity
*SOD↑,
*ROS↓, protective effects on different markers of oxidative damage in hippocampal tissue from ischemic rats
*GPx↑, crocin increased the activity of SOD and glutathione peroxidase (GPx) and remarkably reduced malondialdehyde (MDA) content in the ischemic cortex in rat model of ischemic stroke
*MDA↓,
*memory↑, Saffron extract and crocin can improve learning and memory
*antiOx↑, crocetin increases the antioxidant potential in brain and helps to fight against 6-OHDA-induced neurotoxicity
*Inflam↓, prevented diazinon (20 mg/kg)-induced increase of inflammation
*other↓, Administration of crocin (60 mg/kg), one hour before, or one hour after the induction of ischemia, reduced brain edema
*ER Stress↓, Administration of crocin on day 7 post-EAE induction, suppressed ER stress and inflammatory gene expression in the spinal cord

5055- Ex,    Why exercise has a crucial role in cancer prevention, risk reduction and improved outcomes
- Review, Var, NA
OS↑, In 2008, a cohort study of breast cancer survivors identified that patients who consistently exercised for greater than 2.5 hours per week following diagnosis had a greater than 60% reduction in the risk of all deaths compared with patients who were
IGF-1↓, Table 1, IGF1 Decreased levels, IGFBP3 Increased levels
IGFBP3↑,
BRCA1↑, BRCA1 Increased expression
BRCA2↑, BRCA2 Increased expression
RAS↓, RAS family oncogenes Suppressed activity
P53↑, P53 Enhanced activity
HSPs↑, Heat shock proteins Enhanced activity
Leptin↓, Leptin Reduced activity
Irisin↓, Irisin Enhanced activity
Resistin↓, Resistin Reduced activity
NK cell↑, NK cells Enhanced activity
CRP↓, C-reactive protein, interleukin-6, TNFα Reduced activity
IL6↓,
TNF-α↓,
PGE1↓, Prostaglandins Reduced activity
COX2↓, Cox-2 Reduced activity
*GSH↑, Glutathione, Catalase and Superoxide dismutase Increased activity
*Catalase↑,
*SOD↑,
*monoA↑, Monoamines Higher levels
*EndoR↑, Endorphins Increased release
*testos↑, testosterone increases immediately after vigorous exercise in some but not all studies. lasting for 20–60 minutes post-exercise
ROS↑, Physical activity, especially if strenuous, produces reactive oxidative species (ROS)
QoL↑, Adverse cancer-related symptoms, which have been shown to be alleviated by exercise, include fatigue, muscle weakness, thromboembolism, weight gain, loss of bone density, quality of life (QOL), psychological distress, incontinence and sexual dysfunct
BMD↑, the rate of decline in BMD was significantly less in the resistance exercise group, with a greater benefit seen in the aerobic exercise group
BowelM↑, Exercise reduces bowel transit time and ameliorates constipation and its associated abdominal cramps

3619- RosA,    Rosmarinic acid suppresses Alzheimer’s disease development by reducing amyloid β aggregation by increasing monoamine secretion
- Review, AD, NA
*BioAv↓, confirmed that the intestinal permeability of RA is <1% of its intake volume
*BBB↝, migrates to the brain with difficulty due to the presence of the BBB
*monoA↑, RA administration increases monoamines in the brain
*TGF-β↓, Several studies have reported that RA suppresses the expression of Tgf-β1 in vivo and in vitro2
*Aβ↓, Suppression of Aβ aggregation by DA and other monoamines


Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Transcription & Epigenetics ⓘ

BowelM↑, 1,  

Protein Folding & ER Stress ⓘ

HSPs↑, 1,  

DNA Damage & Repair ⓘ

BRCA1↑, 1,   BRCA2↑, 1,   P53↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

IGF-1↓, 1,   IGFBP3↑, 1,   RAS↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   CRP↓, 1,   IL6↓, 1,   NK cell↑, 1,   PGE1↓, 1,   Resistin↓, 1,   TNF-α↓, 1,  

Hormonal & Nuclear Receptors ⓘ

Irisin↓, 1,   Leptin↓, 1,  

Clinical Biomarkers ⓘ

BMD↑, 1,   BRCA1↑, 1,   CRP↓, 1,   IL6↓, 1,  

Functional Outcomes ⓘ

OS↑, 1,   QoL↑, 1,  
Total Targets: 24

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Catalase↑, 1,   GPx↑, 1,   GSH↑, 1,   lipid-P↓, 1,   MDA↓, 1,   ROS↓, 1,   SOD↑, 2,  

Transcription & Epigenetics ⓘ

other↓, 1,   other↑, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↓, 1,  

Migration ⓘ

TGF-β↓, 1,  

Barriers & Transport ⓘ

BBB↝, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  

Synaptic & Neurotransmission ⓘ

AChE↓, 1,   EndoR↑, 1,   monoA↑, 3,  

Protein Aggregation ⓘ

Aβ↓, 2,  

Hormonal & Nuclear Receptors ⓘ

testos↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,  

Functional Outcomes ⓘ

cognitive↑, 1,   memory↑, 1,   neuroP↑, 1,  
Total Targets: 23

Scientific Paper Hit Count for: monoA, monoamines
1 Crocetin
1 Exercise
1 Rosmarinic acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1350  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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